公开(公告)号：EP4230729A1

公开(公告)日：2023-08-23

申请号：EP21880541.4

申请日：2021-10-14

申请人： Sungkwang Medical Foundation ,  Cha Biolab Co., Ltd.

发明人： BAEK, Young Seok ,  AN, Hee Jung ,  KANG, Myung Seo ,  MOON, Yong Wha ,  PARK, Kyung Soon ,  LEE, In Jee ,  HWANG, So Hyun

IPC分类号： C12N5/0783 ,  C12N5/00 ,  A61K35/17 ,  A61K48/00 ,  A61P35/00

摘要： Provided are a method of culturing high-purity, highly active natural killer cells of which expression of anti-cancer-related gene is regulated, and use thereof for anticancer immunotherapy. In the natural killer cells according to one aspect, the expression of anticancer related genes is significantly increased or decreased before and after culture. The natural killer cells have the unique characteristics thereof, and remarkably high activity and proliferation fold. Therefore, the natural killer cells can be used for effective anticancer immunotherapy.

公开(公告)号：EP4067506A1

公开(公告)日：2022-10-05

申请号：EP20893105.5

申请日：2020-11-10

申请人： Sungkwang Medical Foundation

发明人： HWANG, So Hyun ,  LIM, Jae Joon ,  CHA, Kwang Yul ,  AN, Hee Jung ,  KANG, Hae Youn ,  CHO, Kyung Gi ,  HEO, Jin Hyung ,  JOUNG, Je-Gun ,  KIM, Se Wha ,  KWON, Ah Young

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： The disclosure relates to biomarkers for predicting a therapeutic response of a patient to an immune cell therapy. Since gene signatures and markers according to an aspect have an excellent predictive capacity for predicting a patient's therapeutic response to an immune cell therapy, a patient group predicted to exhibit therapeutic effects may be selected to perform an appropriate treatment, and a patient's suffering and costs may be reduced.