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    1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions
    1.
    发明公开
    1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions 失效
    1-Piperazinkarboxamid衍生物，它们的制备方法和它们在药物制剂中使用。

    公开(公告)号：EP0136274A1

    公开(公告)日：1985-04-03

    申请号：EP84850237.3

    申请日：1984-08-02

    申请人： AB Ferrosan

    发明人： Björk, Anders Karl Konrad ,  Olsson, Knut Gunnar ,  Abramo, Aina Lisbeth ,  Fex, Tomas ,  Gustafsson, Bengt Kenneth Roland ,  Christensson, Erik Gunnar

    IPC分类号： C07D295/18 ,  C07D295/20 ,  C07D241/04 ,  C07D317/28 ,  C07D405/06 ,  A61K31/495

    CPC分类号： C07D295/073 ,  C07D295/205 ,  C07D295/21 ,  C07D295/215 ,  C07D317/28

    摘要： 1-piperazinecarboxamide derivatives are described which have the formula (I)
    wherein R, is a member selected from hydrogen, halogen or trifluoromethyl;
    wherein X is selected from:











    wherein R 2 and R 3 are the same or different and selected from hydrogen or lower alkyl;
    wherein Z ist either oxygen or sulfur;
    wherein Y is -NR 4 R 5 , where R 4 and R, are the same or different and selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aryl-(lower alkyl), or R. and R 5 may together with the N-atom form a 5- or 6- or 7-membered satured ring, where one of the carbon atoms may be exchanged for O, NR 8 or NCOR 8 ;
    wherein R 6 and R 7 are the same or different and selected from hydrogen or lower alkyl;
    wherein R 8 is lower alkyl or lower alkenyl;
    with the proviso that when X is > CO, then R 4 is hydrogen and
    R, is different from hydrogen.

    Pharmaceutical compositions containing said 1-piperazinecarboxamide derivates are also described.
    The derivatives are useful in treating mental disorders and/or aggression in man and in treating aggression in animals and for calming animals.
    Different processes for preparing the derivatives are also described.

    摘要翻译： 1-piparazinecarboxamide衍生物中描述了具有... ... worin R1是选自氢，卤素或三氟甲基中选择的部件的式（I）; ...其中X是选自：...> CO（Ia）的...> CHOH（Ib）的 > CHOR8（IB分钟）> CHOCOR8（IB秒）...> CH 2（Ic）的...> C = CR 6 R 7（Id）的...> CH - CHR6R7（IE）... ... worin R2和R3是相同或不同的，并且选择 选自氢或低级烷基; ...其中Z是氧或硫要么; ...其中y是-NR 4 R 5，其中R 4和R 5相同或不同并选自氢，烷基，烯基，环烷基，芳基，芳基 - 选择（低级烷基） ，或R4和R5可与N原子一起形成5-或6-或7-元环缎红，其中碳原子之一可以被交换为O，NR 8或NCOR8; ... worin R6和R7是在 相同或不同并选自氢或低级烷基; ... worin R8是低级烷基或低级链烯基;条件做当X是...> CO，然后R 4是氢和R 5是氢。 ... 药物组合物包含所述1-哌嗪甲酰胺衍生物如此描述。 ... 的衍生物可用于治疗精神障碍和/或在人侵略和治疗动物侵略和平静的动物是有用的。 所以... 用于制备衍生物不同的方法被描述。

    Bacteriological test set for detecting butyric acid bacteria in milk
    3.
    发明公开
    Bacteriological test set for detecting butyric acid bacteria in milk 失效
    Bakteriologischer Testsatz zum Nachweis vonButtersäurebakterienin Milch。

    公开(公告)号：EP0044824A1

    公开(公告)日：1982-01-27

    申请号：EP81850089.4

    申请日：1981-05-20

    申请人： AB Ferrosan

    发明人： Petersson, Leif Ake Sigvard ,  Willard, Lars-Olof

    IPC分类号： G01N33/04 ,  C12Q1/04

    CPC分类号： C12Q1/04 ,  G01N33/04 ,  G01N2333/33

    摘要： Bacteriological testset for establishing the occurrence of butyric acid bacterial (Clostridium) in milk, comprising a sealed, by autoclaving sterilized vial containing a sterilized culture medium for anaerobic and microaerophilic cultivating, and an against the culture medium inert compound, solidifying at a temperature below about 40°C., having a density lower than the density of the culture medium, into which vial the milk to be tested is introduced under aseptic conditions; a method of establishing the occurrence of butyric acid bacteria in milk by adding the milk to be tested via a plastic drain into a sealed, autoclaved vial containing a sterilized culture medium for anaerobic and microaerophilic cultivating, and an against the medium inert compound, solidifying at a temperature below about 40°C., and having a density lower than the density of the culture medium; and the use of the testset for establishing the occurrence of butyric acid bacteria in milk by adding the milk to be tested through a plastic drain into a sealed, autoclaved vial containing a sterilized culture medium for anaerobic and microaerophilic cultivating, and an against the medium inert compound, solidifying at a temperature below about 40°C., and having a density lower than the density of the culture medium; whereafter the vial is heated and incubated and gas formation in the sample is read off.

    摘要翻译： 用于建立牛奶中丁酸细菌（梭菌）的发生的细菌试验组，包括通过高压灭菌灭菌的小瓶，包含用于厌氧和微生物培养的灭菌培养基的密封，以及针对培养基惰性化合物，在低于约 40℃，其密度低于培养基的密度，在无菌条件下将待测试的牛奶引入其中; 通过将待测试的牛奶通过塑料排水口加入到含有用于厌氧和微生物培养的灭菌培养基的密封的高压灭菌小瓶中，并对抗中等惰性化合物，在乳中发生丁酸菌的发生的方法， 温度低于约40℃，密度低于培养基的密度; 以及使用测试仪，通过将待测试的牛奶通过塑料排水口加入到含有灭菌培养基的密封的高压灭菌的小瓶中来进行厌氧和微生物培养，并且针对中等惰性培养物，来确定牛奶中的丁酸菌的发生。 化合物，在低于约40℃的温度下固化，并且其密度低于培养基的密度; 然后将小瓶加热并孵育并读取样品中的气体形成。

    1-Piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them
    9.
    发明公开
    1-Piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them 失效
    1-Piperazinocarboxylate，涉及它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0080992A2

    公开(公告)日：1983-06-08

    申请号：EP82850245.0

    申请日：1982-11-30

    申请人： AB Ferrosan

    发明人： Björk, Anders Karl Konrad ,  Christensson, Erik Gunnar

    IPC分类号： C07D295/20 ,  C07D241/04 ,  A61K31/495

    CPC分类号： C07D295/205

    摘要： Diphenylbutyl-1-piperazinocarboxylates of the formula
    wherein R is alkyl straight or branch chained having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, aralkyl having from 7 to 9 carbon atoms or phenyl unsubstituted or substituted by one to three F, Cl, Br, lower alkyl having from 1 to 5 carbon atoms, lower alkoxy having from 1 to 5 carbon atoms, alkylenedioxy having from 1 to 3 carbon atoms, -CF 3 or -CN substituents, R,-R 4 are independently H, CH 3 , C 2 H 5 with cis or trans configuration provided that only two of them are other than hydrogen, and pharmaceutically acceptable salts thereof are described. Processes for their preparation are also described.
    The compounds are useful for treatment of mental disorders, such as aggression and psychosis in mammals.