公开(公告)号：EP3757090B1

公开(公告)日：2024-06-12

申请号：EP20177336.3

申请日：2009-11-10

IPC: C07D317/46 ,  A61K31/713 ,  A61P33/00 ,  A61K9/127 ,  A61K31/7088 ,  A61P37/04 ,  C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D405/12 ,  C07D317/72 ,  C07D491/056 ,  A61K39/00 ,  A61P35/00 ,  C07D319/06 ,  C07D491/113 ,  C12N15/11

CPC classification number: A61K39/00 ,  C12N15/111 ,  A61K9/1272 ,  A61K31/713 ,  C07D319/06 ,  C07D317/28 ,  C07D203/10 ,  A61K31/7088 ,  C07D317/44 ,  C07D317/46 ,  C07D317/72 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  A61P33/00 ,  A61P35/00 ,  A61P37/04 ,  Y02A50/30

公开(公告)号：EP3210623B1

公开(公告)日：2022-10-05

申请号：EP15851936.3

申请日：2015-10-22

Inventor： TSUBUSAKI Takuma ,  YAMAMOTO Yuji

IPC: A61K39/395 ,  A61K45/00 ,  A61K47/22 ,  A61K47/50 ,  A61P35/00 ,  C07K16/00 ,  C07D317/28 ,  C07D405/06 ,  C07D405/14

公开(公告)号：EP3271344B1

公开(公告)日：2020-08-26

申请号：EP16801801.8

申请日：2016-11-29

Applicant: F.I.S.- Fabbrica Italiana Sintetici S.p.A.

Inventor： MARAGNI, Paolo ,  VERZINI, Massimo

IPC: C07D309/14 ,  C07D317/28 ,  C07C215/00 ,  C07D303/36 ,  C07C309/00 ,  C07C233/00 ,  C07C233/18 ,  C07C271/16 ,  C07C309/73 ,  C07D317/72

公开(公告)号：EP3100718B1

公开(公告)日：2019-11-27

申请号：EP16163003.3

申请日：2008-12-31

Applicant: Arbutus Biopharma Corporation ,  The University of British Columbia ,  Alnylam Pharmaceuticals, Inc.

Inventor： HOPE, Michael, J. ,  SEMPLE, Sean C. ,  CHEN, Jianxin ,  MADDEN, Thomas D. ,  MUI, Barbara ,  CULLIS, Pieter R. ,  CIUFOLINI, Marco A. ,  WONG, Kim F. ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil G. ,  SRINIVASULU, Masunu

IPC: A61K9/127 ,  A61K31/7088 ,  C07D317/28 ,  C07C229/30

公开(公告)号：EP2986665B1

公开(公告)日：2018-10-17

申请号：EP14784993.9

申请日：2014-04-18

Applicant: Adesso Advanced Materials Wuhu Co., Ltd.

Inventor： QIN, Bing ,  LI, Xin ,  LIANG, Bo

IPC: C08J11/16 ,  C08J11/28 ,  C08L63/00 ,  C08G59/50 ,  C07D317/28 ,  C08J11/24 ,  C08K7/06 ,  D01F9/12

CPC classification number: C08G59/5046 ,  C07D317/28 ,  C08J11/24 ,  C08K7/06 ,  D01F9/12

Abstract: The present invention provides, among others, compounds of the following formula which can be used as degradable curing agents, methods for preparing the compounds, degradable polymers and reinforced composites, methods for degrading and recycling the polymers and composites.

公开(公告)号：EP2399893B1

公开(公告)日：2018-08-15

申请号：EP11177567.2

申请日：2005-12-21

Applicant: Ambrx, Inc.

Inventor： Miao, Zhenwei ,  Liu, Junjie ,  Norman, Thea ,  Driver, Russell

IPC: C07C22/00 ,  C07C227/00 ,  C07C2/00 ,  A61K38/00 ,  C07C251/28 ,  C07D307/83 ,  C07D307/88 ,  C07D307/89 ,  C07D317/22 ,  C07D317/26 ,  C07D317/28 ,  C07D317/30 ,  C07D333/72 ,  C07C229/36 ,  C07C237/32 ,  C07C251/54 ,  C07C251/60 ,  C07C251/86 ,  C07C323/63 ,  C07D209/38

CPC classification number: C07C225/10 ,  A61K31/198 ,  A61K38/17 ,  A61K47/08 ,  A61K47/10 ,  A61K47/34 ,  A61K47/60 ,  C07C229/36 ,  C07C237/32 ,  C07C251/28 ,  C07C251/54 ,  C07C251/60 ,  C07C251/86 ,  C07C323/63 ,  C07C2601/08 ,  C07D209/38 ,  C07D209/46 ,  C07D307/83 ,  C07D307/88 ,  C07D307/89 ,  C07D317/22 ,  C07D317/26 ,  C07D317/28 ,  C07D317/30 ,  C07D333/72 ,  C07K14/61 ,  C12P21/02 ,  G01N33/5008 ,  G01N33/68 ,  G01N33/6848 ,  G01N2500/00 ,  Y02A50/473 ,  Y02P20/55

Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：EP3286172A1

公开(公告)日：2018-02-28

申请号：EP16719190

申请日：2016-04-22

Applicant: CONSTELLATION PHARMACEUTICALS INC

Inventor： ALBRECHT BRIAN K ,  AUDIA JAMES EDMUND ,  COTE ALEXANDRE ,  DUPLESSIS MARTIN ,  GEHLING VICTOR S ,  HARMANGE JEAN-CHRISTOPHE ,  VASWANI RISHI G

IPC: C07D309/20 ,  C07C211/22 ,  C07C211/35 ,  C07C215/44 ,  C07D205/12 ,  C07D207/32 ,  C07D211/22 ,  C07D211/26 ,  C07D211/36 ,  C07D215/44 ,  C07D239/30 ,  C07D263/32 ,  C07D317/28 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D417/06

CPC classification number: C07D211/26 ,  C07B2200/07 ,  C07C211/09 ,  C07C211/36 ,  C07C211/40 ,  C07C215/14 ,  C07C215/44 ,  C07C217/08 ,  C07C229/10 ,  C07C229/38 ,  C07C229/46 ,  C07C233/41 ,  C07C237/06 ,  C07C255/24 ,  C07C255/58 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/44 ,  C07D205/12 ,  C07D207/32 ,  C07D211/22 ,  C07D211/36 ,  C07D213/64 ,  C07D215/44 ,  C07D239/30 ,  C07D263/32 ,  C07D305/06 ,  C07D309/20 ,  C07D317/28 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D417/06

Abstract: Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSDl.

公开(公告)号：EP3271344A1

公开(公告)日：2018-01-24

申请号：EP16801801.8

申请日：2016-11-29

Applicant: F.I.S.- Fabbrica Italiana Sintetici S.p.A.

Inventor： MARAGNI, Paolo ,  VERZINI, Massimo

IPC: C07D309/14 ,  C07D317/28 ,  C07C215/00 ,  C07D303/36 ,  C07C309/00 ,  C07C233/00

Abstract: The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).

公开(公告)号：EP3100718A1

公开(公告)日：2016-12-07

申请号：EP16163003.3

申请日：2008-12-31

Applicant: Arbutus Biopharma Corporation ,  The University of British Columbia ,  Alnylam Pharmaceuticals

Inventor： HOPE, Michael, J. ,  SEMPLE, Sean C. ,  CHEN, Jianxin ,  MADDEN, Thomas D. ,  MUI, Barbara ,  CULLIS, Pieter R. ,  CIUFOLINI, Marco A. ,  WONG, Kim F. ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil G. ,  SRINIVASULU, Masunu

IPC: A61K9/127 ,  A61K31/7088 ,  C07D317/28 ,  C07C229/30

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract translation: 本发明提供了用于将治疗剂递送至细胞的组合物和方法。 具体而言，这些包括新型脂质和核酸 - 脂质颗粒，其提供有效的核酸包封和将包封的核酸有效递送至体内细胞。 本发明的组合物非常有效，从而允许以相对低的剂量有效敲减特定靶蛋白。 另外，本发明的组合物和方法毒性较低，并且与本领域先前已知的组合物和方法相比提供了更大的治疗指数。

公开(公告)号：EP2716630A4

公开(公告)日：2015-06-03

申请号：EP12792034

申请日：2012-05-17

Applicant: SUMITOMO CHEMICAL CO

Inventor： IKEMOTO TETSUYA ,  LUTETE LEOPOLD MPAKA ,  AIKAWA TOSHIAKI

IPC: C07D209/52 ,  C07C205/29 ,  C07C217/44 ,  C07C271/16 ,  C07C271/18 ,  C07D317/16 ,  C07D317/28

CPC classification number: C07C223/02 ,  C07C201/12 ,  C07C205/29 ,  C07C213/02 ,  C07C213/08 ,  C07C217/44 ,  C07C269/04 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/08 ,  C07D209/52 ,  C07D317/16 ,  C07D317/28 ,  C07C205/44