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1.发明公开Process for the extraction of factor VIII-von willebrand factor (FVIII:C-FVW) complex from total human plasma 失效从总人血浆中提取因子VIII-von维勒布兰德因子（FVIII：C-FVW）复合物的方法
公开(公告)号：EP0600480A2
公开(公告)日：1994-06-08
申请号：EP93119439.3
申请日：1993-12-02
CPC分类号： C07K14/755
摘要： A process for the extraction of Factor VIII - von Willebrand Factor (FVIII:C - FvW) complex from total human plasma is described, comprising unfreezing the plasma at room temperature after stabilization, selective absorption on anionic exchanger of factors constituting the protrombinic complex, extraction, on anionic exchanger as well, of Factor VIII - von Willebrand Factor (FVIII:C - FvW) complex and a further purification by means of a cationic exchanger of FVIII:C - FvW suitably stabilized and inactivated.
摘要翻译： 描述了从全人血浆中提取因子VIII-von Willebrand因子（FVIII：C-FvW）复合物的方法，包括在稳定后在室温下解冻血浆，在阴离子交换剂上选择性吸收构成该复合物的因子，提取 上的阴离子交换剂，以及，因子VIII的 - 血管性血友病因子（FVIII：C - FVW）配合物和由FVIII的阳离子交换的手段进一步纯化：C - FVW适当稳定并失活。
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2.发明公开Process for the extraction and purification of alfa1-antitrypsin (alfa1-pI) from cohn IV-1 fraction 失效Verfahren zur Extraktion und Reinigung von Alpha-1-Antitypypsin（alpha 1-pI）aus Cohnischer Fraktion IV-1
公开(公告)号：EP0717049A1
公开(公告)日：1996-06-19
申请号：EP94119902.8
申请日：1994-12-16
发明人： Arrighi, Silvana , Bardotti, Angela , Bucci, Enzo
IPC分类号： C07K14/81
CPC分类号： C07K14/8121
摘要： It is described a process for the extraction and following purification of alfa1-antitrypsin (alfa1-pI) from Cohn IV-1 Fraction, such process comprising the following steps:
a) solubilization of the starting paste constituted by Cohn IV-1 Fraction and fractioned precipitation;
b) hydrophobic interaction chromatography;
c) viral inactivation; and
d) final operations.摘要翻译： 描述了从Cohn IV-1馏分中提取和纯化α-1-抗胰蛋白酶（α-1-pI）的方法，该方法包括以下步骤：a）溶解由Cohn IV-1馏分构成的起始糊状物并分级 沉淀; b）疏水相互作用层析; c）病毒灭活; 和d）最后的操作。 FO
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3.发明公开Process for the extraction of factor VIII-von willebrand factor (FVIII:C-FVW) complex from total human plasma 失效从人血浆络合物：一种用于因子VIII-von Willebrand因子（C-FVW FVIII）的纯化方法。
公开(公告)号：EP0600480A3
公开(公告)日：1994-11-23
申请号：EP93119439.3
申请日：1993-12-02
CPC分类号： C07K14/755
摘要： A process for the extraction of Factor VIII - von Willebrand Factor (FVIII:C - FvW) complex from total human plasma is described, comprising unfreezing the plasma at room temperature after stabilization, selective absorption on anionic exchanger of factors constituting the protrombinic complex, extraction, on anionic exchanger as well, of Factor VIII - von Willebrand Factor (FVIII:C - FvW) complex and a further purification by means of a cationic exchanger of FVIII:C - FvW suitably stabilized and inactivated.
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4.发明公开Process for the isolation of highly purified factors IX, X and II from prothrombin complex or human plasma 失效一种用于从凝血酶原复合物或人血浆高度富集因子IX，X和II的隔离过程。
公开(公告)号：EP0617049A1
公开(公告)日：1994-09-28
申请号：EP93104633.8
申请日：1993-03-22
CPC分类号： C12N9/647 , C07K14/745 , C12N9/6429 , C12Y304/21005
摘要： A description is given of a process for the purification of factor IX, factor X, and factor II from human plasma or fractions thereof, wherein a solution containing prothrombin complex factors is purified by repeated ion exchange chromatographic separations followed by adsorption chromatography on metal ions.
摘要翻译： 下面说明一个过程的因子IX，因子X和因子II的自人血浆或它们的级分的纯化，worin含凝血酶原复合因子的溶液通过随后对金属离子吸附色谱法重复离子交换色谱分离纯化。
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