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1.发明公开
公开(公告)号：EP1534344A2
公开(公告)日：2005-06-01
申请号：EP03762001.0
申请日：2003-06-25
IPC分类号： A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10043 , C12N2720/10061 , C12N2720/10062 , C12N2720/12023 , C12N2730/10122 , C12N2730/10134 , C12N2740/16034 , C12N2740/16061 , C12N2770/22022 , C12N2770/22023 , C12N2770/22043 , C12N2770/32043 , C12N2810/854
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components, then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.
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2.发明公开
公开(公告)号：EP1534344A4
公开(公告)日：2008-05-28
申请号：EP03762001
申请日：2003-06-25
发明人： ALLNUTT F C THOMAS , KYLE DAVID J
IPC分类号： A61K39/00 , A61K39/21 , A61K39/29 , C07K14/01 , C07K14/08 , C07K14/16 , C12N7/00 , C12N7/04 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10043 , C12N2720/10061 , C12N2720/10062 , C12N2720/12023 , C12N2730/10122 , C12N2730/10134 , C12N2740/16034 , C12N2740/16061 , C12N2770/22022 , C12N2770/22023 , C12N2770/22043 , C12N2770/32043 , C12N2810/854
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