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公开(公告)号：EP1757686A1
公开(公告)日：2007-02-28
申请号：EP04726750.5
申请日：2004-04-09
发明人： OZAKI, Shuji , ABE, Masahiro , TSUCHIYA, Masayuki, CHUGAI SEIYAKU KABUSHIKI K. , KIMURA, Naoki, CHUGAI SEIYAKU KABUSHIKI KAISHA , KAWAI, Shigeto, CHUGAI SEIYAKU KABUSHIKI KAISHA
CPC分类号： C07K16/2833 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73
摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. As a result, the 2D7 antibody was found to recognize HLA class IA. In addition, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
摘要翻译： 为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。 结果发现2D7抗体识别HLA class IA。 另外，本发明人研究了2D7抗体是否具有细胞死亡诱导活性。 当2D7抗体与另一种抗体交联时观察到核碎裂，表明细胞死亡被诱导。 此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使不添加另一种抗体也是如此。 这些结果表明可以将HLA-识别抗体的微抗体用作细胞死亡诱导剂。
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公开(公告)号：EP1561759A4
公开(公告)日：2006-05-31
申请号：EP03751456
申请日：2003-10-10
发明人： OZAKI SHUJI , ABE MASAHIRO , TSUCHIYA MASAYUKI , KIMURA NAOKI , KAWAI SHIGETO
IPC分类号： A61P35/00 , A61P37/02 , A61P43/00 , C07K14/74 , C07K16/28 , C12P21/08 , C07K16/18 , A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
摘要： In order to identify an antigen to 2D7 antibody, a 2D7 antigen is cloned. As a result, it is indicated that the 2D7 antigen is an HLA class I molecule. Based on this finding, it is discussed whether the 2D7 antibody has an activity of inducing cell death or not. As a result, nuclear fragmentation is observed by further crosslinking the 2D7 antibody with another antibody, thereby indicating that cell death is induced. It is also clarified that a diabody of the 2D7 antibody has an extremely strong cell death-inducing activity even though no other antibody is added. These results point out that a degradation product of an antibody recognizing HLA is usable as a cell death-inducing agent.
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公开(公告)号：EP1561759B1
公开(公告)日：2008-11-12
申请号：EP03751456.9
申请日：2003-10-10
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
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公开(公告)号：EP1561759A1
公开(公告)日：2005-08-10
申请号：EP03751456.9
申请日：2003-10-10
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
摘要翻译： 为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。 结果表明，2D7抗原是HLA I类分子。 基于该发现，本发明人检查了2D7抗体是否具有细胞死亡诱导活性。 当2D7抗体与另一种抗体交联时，观察到细胞核碎裂，表明诱导细胞死亡。 此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使没有添加另一种抗体。 这些结果表明HLA识别抗体的小体抗体可以用作细胞死亡诱导剂。
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公开(公告)号：EP1561759B9
公开(公告)日：2009-08-26
申请号：EP03751456.9
申请日：2003-10-10
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
摘要： In order to identify an antigen to 2D7 antibody, a 2D7 antigen is cloned. As a result, it is indicated that the 2D7 antigen is an HLA class I molecule. Based on this finding, it is discussed whether the 2D7 antibody has an activity of inducing cell death or not. As a result, nuclear fragmentation is observed by further crosslinking the 2D7 antibody with another antibody, thereby indicating that cell death is induced. It is also clarified that a diabody of the 2D7 antibody has an extremely strong cell death-inducing activity even though no other antibody is added. These results point out that a degradation product of an antibody recognizing HLA is usable as a cell death-inducing agent.
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公开(公告)号：EP1757686A4
公开(公告)日：2008-03-12
申请号：EP04726750
申请日：2004-04-09
发明人： OZAKI SHUJI , ABE MASAHIRO , TSUCHIYA MASAYUKI , KIMURA NAOKI , KAWAI SHIGETO
CPC分类号： C07K16/2833 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73
摘要： Cloning of antigen 2D7 has been carried out to identify an antigen relevant to antibody 2D7. As a result, it has been found that the antibody 2D7 recognizes HLA class IA. Further, whether or not the antibody 2D7 has cell death inducing activity has been studied. As a result, it has been found that nuclear fragmentation is observed by crosslinking of the antibody 2D7 with another antibody to thereby bring about induction of cell death. Still further, it has been found that a diabody of antibody 2D7 exhibits very strong cell death inducing activity even when any other antibody is not added. These results suggest that an antibody with lowered molecular weight among antibodies capable of recognizing HLA can be utilized as a cell death inducer.
摘要翻译： 已经进行抗原2D7的克隆以鉴定与抗体2D7相关的抗原。 结果发现抗体2D7识别HLA类别IA。 此外，研究了抗体2D7是否具有细胞死亡诱导活性。 结果发现，通过抗体2D7与另一种抗体的交联观察到核碎裂，从而诱导细胞死亡。 还发现，即使没有加入任何其它抗体，抗体2D7的双抗体也显示非常强的细胞死亡诱导活性。 这些结果表明，能够识别HLA的抗体中具有降低的分子量的抗体可以用作细胞死亡诱导剂。
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