公开(公告)号：EP4420664A1

公开(公告)日：2024-08-28

申请号：EP23158767.6

申请日：2023-02-27

Applicant: Adamed Pharma S.A.

Inventor： LYSIAK, Magdalena ,  ZARZYCKA, Mariola ,  RZASA, Joanna

IPC: A61K31/439 ,  A61P25/34 ,  A61K9/08 ,  A61K47/02

CPC classification number: A61P25/34 ,  A61K47/02 ,  A61K9/006 ,  A61K31/439 ,  A61K9/08

Abstract: The present invention relates to a stabilized composition with significantly improved shelf-life stability. More particularly, the present invention relates to a stable liquid aqueous pharmaceutical composition comprising cytisine or a pharmaceutically acceptable salt thereof, at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound. The present invention relates also to a use of at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound for the stabilization of a liquid aqueous pharmaceutical composition comprising cytisine.

公开(公告)号：EP3512562A1

公开(公告)日：2019-07-24

申请号：EP17777504.6

申请日：2017-09-15

Applicant: Adamed Pharma S.A.

Inventor： PAWLAK, Sebastian Dominik

IPC: A61K47/64 ,  A61K47/68

公开(公告)号：EP3454838A1

公开(公告)日：2019-03-20

申请号：EP17723657.7

申请日：2017-05-07

Applicant: Adamed Pharma S.A.

Inventor： CIEPLUCHA, Agnieszka

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/00

CPC classification number: A61K9/1635 ,  A61K9/1694 ,  A61K9/2027 ,  A61K9/2077 ,  A61K31/397 ,  A61K31/505 ,  A61K45/06 ,  A61P3/06 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition comprising rosuvastatin and ezetimibe for oral administration in the form of a blend of a first component comprising rosuvastatin or a pharmaceutically acceptable salt thereof, wherein the component is dry-granulated, a second component comprising ezetimibe or a pharmaceutically acceptable salt thereof, wherein the component is wet-granulated, and an optionally extragranular phase component, characterized in that the pharmaceutical composition is free from any rosuvastatin stabilizers, and d 90 value for granules of the first component is 800 µm or less. The invention relates also to an uncoated tablet comprising the composition, and a method of manufacturing the composition.

公开(公告)号：EP2934488B1

公开(公告)日：2018-10-17

申请号：EP13826632.5

申请日：2013-12-19

Applicant: Adamed Pharma S.A.

Inventor： CIEPLUCHA, Agnieszka

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/4184 ,  A61K31/4422

CPC classification number: A61K31/4184 ,  A61K9/1641 ,  A61K9/2077 ,  A61K31/4422 ,  A61K2300/00

Abstract: A combination pharmaceutical composition comprising candesartan cilexetil and amiodipine or a pharmaceutically acceptable salt thereof, a process for the preparation of such composition and unit dosage form comprising such a composition. The composition consists of a granulate containing candesartan cilexetil, polyethylene glycol and other excipients, wherein the weight ratio of candesartan cilexetil to polyethylene glycol is in the range from 5: 1 to 2: 1, and extragranular phase of powder blend comprising amiodipine or a pharmaceutically acceptable salt thereof and excipients. The composition is prepared by mixing the granulate prepared by wet granulation and extragranular phase.

公开(公告)号：EP4465969A1

公开(公告)日：2024-11-27

申请号：EP23701879.1

申请日：2023-01-20

Applicant: Adamed Pharma S.A.

Inventor： WOZNIAK, Lukasz

IPC: A61K9/16

公开(公告)号：EP3834814A1

公开(公告)日：2021-06-16

申请号：EP19461613.2

申请日：2019-12-10

Applicant: Adamed Pharma S.A.

Inventor： KUBIAK, Bartlomiej ,  RZASA, Joanna ,  ZARZYCKA, Mariola ,  GARBERA, Kamil

IPC: A61K9/00 ,  A61K31/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention relates to a liquid pharmaceutical composition comprising cytisine, at least one inorganic pH-regulating agent selected from the group consisting of inorganic acids, inorganic buffers, and inorganic acid salts, and water, wherein the liquid pharmaceutical composition has a pH value between 3.0 and 7.5. The present invention furthermore relates to the liquid pharmaceutical composition for use in the treatment of tobacco smoking addiction and other forms of nicotine addiction. Additionally, the invention relates to a liquid pharmaceutical composition comprising cytisine for oral use in the treatment of tobacco smoking addiction and other forms of nicotine addiction.

公开(公告)号：EP3826618A2

公开(公告)日：2021-06-02

申请号：EP19742030.0

申请日：2019-07-17

Applicant: Adamed Pharma S.A.

Inventor： GARBERA, Kamil ,  RZASA, Joanna

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/439

公开(公告)号：EP3773508A1

公开(公告)日：2021-02-17

申请号：EP19713738.3

申请日：2019-03-21

Applicant: Adamed Pharma S.A.

Inventor： GARBERA, Kamil ,  WOS-LATOSI, Katarzyna

IPC: A61K9/16 ,  A61K31/496 ,  A61K9/20

公开(公告)号：EP3609493A1

公开(公告)日：2020-02-19

申请号：EP18716578.2

申请日：2018-04-03

Applicant: Adamed Pharma S.A.

Inventor： BERDZIK-KALARUS, Sylwia ,  SULIKOWSKI, Daniel

IPC: A61K31/4178 ,  A61K31/4164 ,  A61K31/7048 ,  A61K45/06 ,  A61K9/00 ,  A61K9/20 ,  A61K47/06 ,  A61P31/04

公开(公告)号：EP4403168A1

公开(公告)日：2024-07-24

申请号：EP23152206.1

申请日：2023-01-18

Applicant: Adamed Pharma S.A.

Inventor： BOLTROMIUK, Tomasz ,  SIELUK, Kinga ,  GAJDA, Maciej

IPC: A61K9/24 ,  A61K31/155 ,  A61K31/7048 ,  A61P3/10

CPC classification number: A61K9/209 ,  A61K31/155 ,  A61K31/7048 ,  A61P3/10

Abstract: A fixed-dose pharmaceutical preparation in the form of a coated tablet for oral administration comprising extended release metformin hydrochloride as the core of the tablet, coated with an intermediate coating based on hydroxypropylmethylcellulose as a film-forming material, further coated with empagliflozin comprising active coating based on partially hydrolyzed polyvinyl alcohol as a film-forming material, and further optionally coated with outer protective coating.