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    CELL FREE COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    3.
    发明公开
    CELL FREE COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开

    公开(公告)号：EP4445915A2

    公开(公告)日：2024-10-16

    申请号：EP24177086.6

    申请日：2015-03-24

    申请人： Advanced Regen Medical Technologies, LLC

    发明人： GRECO, Steve

    IPC分类号： A61K45/06

    摘要： A pharmaceutical formulation comprising exosomes derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising a microvesicles derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising an exosome-derived and/or microvesicle derived molecule and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles.

    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    5.
    发明公开
    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    组合物用于生产及其用途的细胞回收及方法

    公开(公告)号：EP2984164A4

    公开(公告)日：2016-11-23

    申请号：EP14782619

    申请日：2014-04-09

    申请人： ADVANCED REGEN MEDICAL TECHNOLOGIES LLC

    发明人： GIAMPAPA VINCENT C

    IPC分类号： C12N5/074 ,  A61K35/12 ,  A61K35/28 ,  A61K45/06 ,  C12N5/02

    CPC分类号： C12N5/0607 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  C12N2502/03 ,  A61K2300/00

    摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.

    摘要翻译： 包括从供体受试者worin供体组合物获得的供体组合物的方法，包括成体干细胞类型的多元性; 获得从一个接收器对象worin接收机组合物包括成体干细胞类型的多个接收器的组合物; 和共培养的供体的组合物和组合物接收器worin共培养包括使所述接收器组合物中的供体组合物的无细胞部分，以产生恢复的组合物。 药物组合物，其包括恢复的组合物。

    CELL FREE COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    6.
    发明公开
    CELL FREE COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    无细胞组合物为生产及其用途的细胞回收及方法

    公开(公告)号：EP3122333A1

    公开(公告)日：2017-02-01

    申请号：EP15768892.0

    申请日：2015-03-24

    申请人： Advanced Regen Medical Technologies, LLC

    发明人： GRECO, Steve

    IPC分类号： A61K9/127 ,  A61K35/12 ,  A61K38/00 ,  A61K38/19 ,  A61K31/7088 ,  A61P17/00

    CPC分类号： A61K35/12 ,  A61K9/0019 ,  A61K45/06

    摘要： A pharmaceutical formulation comprising exosomes derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising a microvesicles derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising an exosome-derived and/or microvesicle derived molecule and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles.

    摘要翻译： 一种药物制剂，其包含从动员干细胞，和一种或多种药学上可接受的载体，佐剂或媒介物外来体衍生。 一种药物制剂，其包含从动员干细胞，和一种或多种药学上可接受的载体，佐剂或媒介物衍生的微泡。 一种药物制剂，其包含外来体衍生的和/或微泡衍生的分子和一种或多种药学上可接受的载体，佐剂或溶媒的。

    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    7.
    发明公开
    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    细胞修复组合物及其制备和使用方法

    公开(公告)号：EP2984164A1

    公开(公告)日：2016-02-17

    申请号：EP14782619.2

    申请日：2014-04-09

    申请人： Advanced Regen Medical Technologies, LLC

    发明人： GIAMPAPA, Vincent C.

    IPC分类号： C12N5/074 ,  C12N5/02 ,  A61K35/12

    CPC分类号： C12N5/0607 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  C12N2502/03 ,  A61K2300/00

    摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.

    摘要翻译： 一种方法，包括从供体受试者获得供体组合物，其中供体组合物包含多种成体干细胞类型; 从接受者受试者获得接受者组合物，其中接受者组合物包含多种成体干细胞类型; 并共培养供体组合物和接受体组合物，其中共同培养包括使接受体组合物与供体组合物的无细胞部分接触以产生恢复的组合物。 包含修复组合物的药物组合物。

    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    9.
    发明公开
    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    细胞修复组合物及其制备和使用方法

    公开(公告)号：EP3083939A1

    公开(公告)日：2016-10-26

    申请号：EP14871789.5

    申请日：2014-12-19

    申请人： Advanced Regen Medical Technologies, LLC

    发明人： GIAMPAPA, Vincent C.

    IPC分类号： C12N5/02 ,  C12N5/078 ,  A61K35/14

    CPC分类号： A61K35/15 ,  A61K35/12 ,  A61K38/18

    摘要： A method comprising obtaining a first cell sample from a first subject; obtaining a second cell sample from a second subject; culturing the first cell sample in the presence of at least a portion of a culture media of the second cell sample for a time period ranging from about 24 hours to about 6 weeks to produce a restoring composition; and contacting the restoring composition with the second cell sample for a period of time ranging from about 24 hours to about 6 weeks to produce a restored composition.

    摘要翻译： 一种方法，包括从第一个受试者获得第一个细胞样品; 从第二个受试者获得第二个细胞样品; 在第二细胞样品的至少一部分培养基存在下培养第一细胞样品约24小时至约6周的时间，以产生恢复组合物; 以及使恢复组合物与第二细胞样品接触约24小时至约6周的时间以产生恢复的组合物。