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    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    2.
    发明公开
    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    组合物用于生产及其用途的细胞回收及方法

    公开(公告)号：EP2984164A4

    公开(公告)日：2016-11-23

    申请号：EP14782619

    申请日：2014-04-09

    申请人： ADVANCED REGEN MEDICAL TECHNOLOGIES LLC

    发明人： GIAMPAPA VINCENT C

    IPC分类号： C12N5/074 ,  A61K35/12 ,  A61K35/28 ,  A61K45/06 ,  C12N5/02

    CPC分类号： C12N5/0607 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  C12N2502/03 ,  A61K2300/00

    摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.

    摘要翻译： 包括从供体受试者worin供体组合物获得的供体组合物的方法，包括成体干细胞类型的多元性; 获得从一个接收器对象worin接收机组合物包括成体干细胞类型的多个接收器的组合物; 和共培养的供体的组合物和组合物接收器worin共培养包括使所述接收器组合物中的供体组合物的无细胞部分，以产生恢复的组合物。 药物组合物，其包括恢复的组合物。

    USE OF STEM CELLS TO REDUCE LEUKOCYTE EXTRAVASATION
    5.
    发明授权
    USE OF STEM CELLS TO REDUCE LEUKOCYTE EXTRAVASATION 有权

    公开(公告)号：EP2456860B1

    公开(公告)日：2018-09-05

    申请号：EP10802822.6

    申请日：2010-07-21

    申请人： ABT Holding Company

    发明人： VAN'T HOF, Wouter

    IPC分类号： C12N5/071 ,  C12N5/074

    CPC分类号： C12N5/0634 ,  A61K35/545 ,  C12N5/0607 ,  C12N2502/03 ,  C12N2502/11 ,  G01N33/5073

    摘要： The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in leukocytes. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.

    USE OF STEM CELLS TO REDUCE LEUKOCYTE EXTRAVASATION
    6.
    发明公开
    USE OF STEM CELLS TO REDUCE LEUKOCYTE EXTRAVASATION 有权
    干细胞，可降低血液白细胞外渗USE

    公开(公告)号：EP2456860A1

    公开(公告)日：2012-05-30

    申请号：EP10802822.6

    申请日：2010-07-21

    申请人： ABT Holding Company

    发明人： VAN'T HOF, Wouter

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0634 ,  A61K35/545 ,  C12N5/0607 ,  C12N2502/03 ,  C12N2502/11 ,  G01N33/5073

    摘要： The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in leukocytes. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.

    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME
    9.
    发明公开
    COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME 审中-公开
    细胞修复组合物及其制备和使用方法

    公开(公告)号：EP2984164A1

    公开(公告)日：2016-02-17

    申请号：EP14782619.2

    申请日：2014-04-09

    申请人： Advanced Regen Medical Technologies, LLC

    发明人： GIAMPAPA, Vincent C.

    IPC分类号： C12N5/074 ,  C12N5/02 ,  A61K35/12

    CPC分类号： C12N5/0607 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  C12N2502/03 ,  A61K2300/00

    摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.

    摘要翻译： 一种方法，包括从供体受试者获得供体组合物，其中供体组合物包含多种成体干细胞类型; 从接受者受试者获得接受者组合物，其中接受者组合物包含多种成体干细胞类型; 并共培养供体组合物和接受体组合物，其中共同培养包括使接受体组合物与供体组合物的无细胞部分接触以产生恢复的组合物。 包含修复组合物的药物组合物。