公开(公告)号：EP3034130A1

公开(公告)日：2016-06-22

申请号：EP14382545.3

申请日：2014-12-19

申请人： Althia Health, S.L. ,  Consejo Superior De Investigaciones Científicas

发明人： Silva Gonzalez, Augusto ,  Garcia Sanz, José Alberto

IPC分类号： A61P35/00 ,  C07K16/30 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC分类号： G01N33/574 ,  A61K49/1875 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/3053 ,  G01N33/54326 ,  G01N33/57492 ,  G01N2446/20 ,  G01N2446/84

摘要： The invention relates to the use of the monoclonal antibody NILO1 for the diagnosis, treatment and/or prevention of brain tumors and lesions. Particularly, the invention relates to methods for the diagnosis of brain tumors and brain lesions in which cells marked with said antibody, or with immunologically active fragments thereof, are detected. The invention also relates to the use of said monoclonal antibody, or immunologically active fragments thereof, as a medicament for the treatment and/or prevention of brain tumors and brain lesions. In a preferred embodiment of the invention, the monoclonal antibody NILO1, or its immunologically active fragments, are humanized.

摘要翻译： 本发明涉及使用单克隆抗体NILO1的用于诊断，治疗和/或预防脑肿瘤和病变。 具体地说，本发明涉及用于脑肿瘤和脑病变的诊断中哪个标记所述抗体，或具有免疫学活性片段，检测细胞的方法。 因此，本发明涉及使用所述单克隆抗体，或其免疫活性片段的，作为用于治疗和/或预防脑肿瘤和脑损伤的药物的用途。 在本发明的一个优选实施方案中，单克隆抗体NILO1，或其免疫活性片段，是人源化。