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    NUCLEATION AND GROWTH OF MAGNETIC METAL OXIDE NANOPARTICLES AND ITS USE
    2.
    发明授权
    NUCLEATION AND GROWTH OF MAGNETIC METAL OXIDE NANOPARTICLES AND ITS USE 有权
    芽形成和金属纳米粒子和使用生长

    公开(公告)号：EP1088315B1

    公开(公告)日：2003-06-25

    申请号：EP99925247.1

    申请日：1999-05-24

    申请人： BAR-ILAN UNIVERSITY

    发明人： MARGEL, Shlomo ,  GURA, Sigalit

    IPC分类号： H01F1/00 ,  B03C1/01 ,  G01N33/543 ,  A61K49/00

    CPC分类号： B82Y25/00 ,  A61K49/1881 ,  B03C1/01 ,  B82Y5/00 ,  G01N33/5434 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84 ,  H01F1/0054 ,  H01F1/445

    摘要： A method for preparing nanoparticles coated with magnetic metal oxide, comprising the following steps: a) contacting an aqueous solution containing a soluble polymeric metal chelating agent with one or more soluble metal salts providing metal ions, wherein at least one of said metal ions is capable of forming an oxide which is magnetic, said metal ions being in amounts which do not exceeed substantially the binding capacity of said chelating agent; b) causing said metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; c) maintaining the pH of the solution at the range of at least 7; d) introducing into the solution additional amounts of said metal salts; e) causing said additional metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; f) maintaining the pH of the solution at the range of at least 7; g) successively repeating the operations of steps d) to f) as many times as required to obtain monodispersed nanoparticles coated with magnetic metal oxide.

    NUCLEATION AND GROWTH OF MAGNETIC METAL OXIDE NANOPARTICLES AND ITS USE
    3.
    发明公开
    NUCLEATION AND GROWTH OF MAGNETIC METAL OXIDE NANOPARTICLES AND ITS USE 有权
    芽形成和金属纳米粒子和使用生长

    公开(公告)号：EP1088315A1

    公开(公告)日：2001-04-04

    申请号：EP99925247.1

    申请日：1999-05-24

    申请人： BAR-ILAN UNIVERSITY

    发明人： MARGEL, Shlomo ,  GURA, Sigalit

    IPC分类号： H01F1/00 ,  B03C1/01 ,  G01N33/543 ,  A61K49/00

    CPC分类号： B82Y25/00 ,  A61K49/1881 ,  B03C1/01 ,  B82Y5/00 ,  G01N33/5434 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84 ,  H01F1/0054 ,  H01F1/445

    摘要： A method for preparing nanoparticles coated with magnetic metal oxide, comprising the following steps: a) contacting an aqueous solution containing a soluble polymeric metal chelating agent with one or more soluble metal salts providing metal ions, wherein at least one of said metal ions is capable of forming an oxide which is magnetic, said metal ions being in amounts which do not exceeed substantially the binding capacity of said chelating agent; b) causing said metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; c) maintaining the pH of the solution at the range of at least 7; d) introducing into the solution additional amounts of said metal salts; e) causing said additional metal ions to be present in the oxidation states required for the formation of the oxide which is magnetic; f) maintaining the pH of the solution at the range of at least 7; g) successively repeating the operations of steps d) to f) as many times as required to obtain monodispersed nanoparticles coated with magnetic metal oxide.

    Biological magnetic fluids
    9.
    发明公开
    Biological magnetic fluids 失效
    生物磁性流体

    公开(公告)号：EP0156537A3

    公开(公告)日：1987-05-13

    申请号：EP85301442

    申请日：1985-03-01

    申请人： THE BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

    发明人： Poynton, Christopher H. ,  Reading, Christopher L.

    IPC分类号： H01F01/37 ,  H01F01/28

    CPC分类号： B03C1/01 ,  A61K9/5094 ,  A61M1/3618 ,  G01N33/5434 ,  G01N2333/76 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84

    摘要： A biological magnetic fluid includes a magnetic colloidal disperse phase distributed throughout a liquid dispersion medium. The disperse phase may be made up of magnetic particles coated with cross-linked biologically compatible polymers. The biologically compatible polymers may be connected by way of covalent linkages to biologically active macromolecules. This may be accomplished by covalently linking immunoglobulin to the biologically compatible polymers and then attaching antibodies with predefined specificity to the immunoglobulin. These antibodies may target the magnetic particles on desired cells, for a variety of medical applications. The magnetic particles may be made up of magnetite cores with cobalt or cobalt and boron coatings. In addition magnetic particles may be made of icobalt and boron with the boron being in sufficient concentration to enable radiation activation. The magnetic colloid may be formed by incorporating the biologically compatible polymer into the colloid as the colloid is being formed by reducing a magnetic metallic salt. The colloid is advantageously produced in a multi-stage process in order to achieve very uniform particle sizes. The magnetic colloid may also be made by forming a biologically incompatible magnetic colloid, and slowly adding the colloid to a vigorous I biologically compatible polymer. These biological magnetic fluids are useful, for example, in separating cancerous cells from normal cells in bone marrow transplants.

    摘要翻译： 生物磁性流体包括分散在液体分散介质中的磁性胶体分散相。 分散相可以由涂覆有交联的生物相容性聚合物的磁性颗粒组成。 生物相容的聚合物可以通过共价键与生物活性大分子连接。 这可以通过将免疫球蛋白共价连接到生物相容性聚合物上，然后将具有预定义特异性的抗体连接到免疫球蛋白来实现。 这些抗体可以靶向所需细胞上的磁性颗粒，用于各种医学应用。 磁性颗粒可以由具有钴或钴和硼涂层的磁铁矿芯组成。 此外，磁性颗粒可以由钴和硼制成，硼具有足够的浓度以使辐射活化。 磁性胶体可以通过将生物相容的聚合物掺入胶体中而形成，因为通过还原磁性金属盐形成胶体。 有利地，在多阶段方法中制备胶体以获得非常均匀的粒度。 磁性胶体也可以通过形成生物不相容的磁性胶体，并将胶体缓慢加入到生物相容性较强的聚合物中制成。 这些生物磁性流体可用于例如在骨髓移植中从正常细胞分离癌细胞。