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公开(公告)号：EP2176288B1
公开(公告)日：2015-11-04
申请号：EP08773964.5
申请日：2008-07-10
申请人： Apogenix GmbH
IPC分类号： C07K14/525 , C12N15/28 , C12N15/62 , A61K38/19 , C12N5/10
CPC分类号： C07K14/70575 , C07K14/42 , C07K14/47 , C07K14/4726 , C07K14/525 , C07K19/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/22 , C07K2319/32 , C07K2319/70 , C12N15/62
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公开(公告)号：EP2310509B1
公开(公告)日：2015-01-21
申请号：EP09780803.4
申请日：2009-07-18
申请人： Apogenix GmbH
IPC分类号： C12N15/62 , C12N15/11 , C07K14/525 , C07K14/705 , A61K38/17
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：EP2604693A3
公开(公告)日：2014-01-08
申请号：EP13152482.9
申请日：2009-07-18
申请人： Apogenix GmbH
IPC分类号： C12N15/62 , C12N15/11 , C07K14/525 , C07K14/705 , A61K38/17
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：EP2310509A1
公开(公告)日：2011-04-20
申请号：EP09780803.4
申请日：2009-07-18
申请人： Apogenix GmbH
IPC分类号： C12N15/62 , C12N15/11 , C07K14/525 , C07K14/705 , A61K38/17
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含三种可溶性TNF超家族（TNFSF）细胞因子结构域和编码这些融合蛋白的核酸分子的单链融合蛋白。 融合蛋白基本上是非聚集的并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：EP2310409A2
公开(公告)日：2011-04-20
申请号：EP09779764.1
申请日：2009-06-15
申请人： Apogenix GmbH
IPC分类号： C07K14/705 , C12N15/62
CPC分类号： C07K14/70578 , A61K38/00 , C12N15/62
摘要： The present invention refers to fusion proteins comprising a TNF receptor family extracellular domain fused to a trimerization domain, and a nucleic acid molecule encoding the fusion protein. The fusion protein may be present as a trimeric complex. It is suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：EP2041576A2
公开(公告)日：2009-04-01
申请号：EP07764767.5
申请日：2007-06-21
申请人： Apogenix GmbH
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N33/6863
摘要： The invention concerns a method for diagnosing a cancer type, whereby the expression of anti-apoptotic cytokines is determined in the tumour cells. The differential diagnosis of the present invention is used to classify tumour disorders and to recommend the required treatment and to monitor the progress and response to the treatment.
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公开(公告)号：EP1894940A1
公开(公告)日：2008-03-05
申请号：EP06017891.0
申请日：2006-08-28
申请人： Apogenix GmbH
IPC分类号： C07K14/01 , C07K14/525 , C07K14/705 , C12N15/62 , A61K38/16
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/73
摘要： The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及融合蛋白质，其包含融合到三聚结构域的TNF超家族（TNFSF）细胞因子或其受体结合结构域和编码融合蛋白的核酸分子。 融合蛋白以三聚体复合物或其低聚物形式存在，并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：EP2604693B1
公开(公告)日：2016-02-24
申请号：EP13152482.9
申请日：2009-07-18
申请人： Apogenix GmbH
IPC分类号： C12N15/62 , C12N15/11 , C07K14/525 , C07K14/705 , A61K38/17
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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9.发明公开INHIBITORS OF THE CD95 SIGNALING PATHWAY FOR TREATMENT OF MDS 有权INHIBITOREN DES CD95-SIGNALWEGES ZUR BEHANDLUNG VON MDS
公开(公告)号：EP2874659A1
公开(公告)日：2015-05-27
申请号：EP13739979.6
申请日：2013-07-18
申请人： Apogenix GmbH
发明人： FRICKE, Harald , FONTENAY, Michaela
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , G01N33/569
CPC分类号： C07K16/2875 , A61K38/177 , A61K39/3955 , A61K45/06 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N2333/70575 , G01N2800/22
摘要： The present invention relates to inhibitors of the CD95 signaling pathway for the use in the treatment of Myelodysplastic Syndrom (MDS) wherein the MDS is selected from the IPSS low risk MDS subgroup and/or the IPSS intermediate-1 (int-1) risk MDS subgroup as well as a method for the diagnosis of MDS.
摘要翻译： 本发明涉及用于治疗骨髓增生异常综合征（MDS）的CD95信号通路抑制剂，其中MDS选自IPSS低风险MDS亚组和/或IPSS中间-1（int-1）风险MDS 亚组以及诊断MDS的方法。
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公开(公告)号：EP2540740A3
公开(公告)日：2013-04-24
申请号：EP12176681.0
申请日：2009-06-15
申请人： Apogenix GmbH
IPC分类号： C07K14/705 , C12N15/62
CPC分类号： C07K14/70578 , A61K38/00 , C12N15/62
摘要： The present invention refers to fusion proteins comprising a TNF receptor family extracellular domain fused to a trimerization domain, and a nucleic acid molecule encoding the fusion protein. The fusion protein may be present as a trimeric complex. It is suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含与三聚化结构域融合的TNF受体家族胞外结构域和编码融合蛋白的核酸分子的融合蛋白。 融合蛋白可以作为三聚体复合物存在。 它适用于治疗，诊断和/或研究应用。
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