公开(公告)号：EP2644701A1

公开(公告)日：2013-10-02

申请号：EP13001576.1

申请日：2013-03-27

申请人： Parks, Christopher L. ,  Wright, Kevin J. ,  Yuan, Maoli ,  Jurgens, Christy K. ,  Zhang, Xinsheng ,  Arban Domi ,  Hoffenberg, Simon ,  Chiuchiolo, Maria J. ,  Rabinovich, Svetlana ,  Wilson, Aaron J. ,  Lorenz, Ivo C.

发明人： Parks, Christopher L. ,  Wright, Kevin J. ,  Yuan, Maoli ,  Jurgens, Christy K. ,  Zhang, Xinsheng ,  Arban Domi ,  Hoffenberg, Simon ,  Chiuchiolo, Maria J. ,  Rabinovich, Svetlana ,  Wilson, Aaron J. ,  Lorenz, Ivo C.

IPC分类号： C12N15/67 ,  C12N15/68 ,  C07K14/005

CPC分类号： C12N15/68 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N15/67 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/16034 ,  C12N2760/18443 ,  C12N2760/20243

摘要： The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

摘要翻译： 本发明涉及通过修饰蛋白质序列来改变与宿主载体更相容的基因插入物的方法，以减少对载体繁殖的潜在干扰，同时确保蛋白质被有效表达和加工并保持所需的结构特征，并设计基因 其核苷酸序列类似于宿主载体基因组的基本组成。