公开(公告)号：EP2676676A1

公开(公告)日：2013-12-25

申请号：EP13001478.0

申请日：2013-03-22

申请人： Rabinovich, Svetlana ,  Yuan, Maoli ,  Wilson, Aaron J. ,  Phogat, Sanjay ,  Lindsay, Ross W. B. ,  Chiuchiolo, Maria J. ,  Parks, Christopher L.

发明人： Rabinovich, Svetlana ,  Yuan, Maoli ,  Wilson, Aaron J. ,  Phogat, Sanjay ,  Lindsay, Ross W. B. ,  Chiuchiolo, Maria J. ,  Parks, Christopher L.

IPC分类号： A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  C12N2740/16134 ,  C12N2760/20243

摘要： The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.

摘要翻译： 本发明涉及重组水泡性口炎病毒，用作艾滋病感染性疾病的预防和治疗性疫苗。 本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

公开(公告)号：EP2644701A1

公开(公告)日：2013-10-02

申请号：EP13001576.1

申请日：2013-03-27

申请人： Parks, Christopher L. ,  Wright, Kevin J. ,  Yuan, Maoli ,  Jurgens, Christy K. ,  Zhang, Xinsheng ,  Arban Domi ,  Hoffenberg, Simon ,  Chiuchiolo, Maria J. ,  Rabinovich, Svetlana ,  Wilson, Aaron J. ,  Lorenz, Ivo C.

发明人： Parks, Christopher L. ,  Wright, Kevin J. ,  Yuan, Maoli ,  Jurgens, Christy K. ,  Zhang, Xinsheng ,  Arban Domi ,  Hoffenberg, Simon ,  Chiuchiolo, Maria J. ,  Rabinovich, Svetlana ,  Wilson, Aaron J. ,  Lorenz, Ivo C.

IPC分类号： C12N15/67 ,  C12N15/68 ,  C07K14/005

CPC分类号： C12N15/68 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N15/67 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/16034 ,  C12N2760/18443 ,  C12N2760/20243

摘要： The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

摘要翻译： 本发明涉及通过修饰蛋白质序列来改变与宿主载体更相容的基因插入物的方法，以减少对载体繁殖的潜在干扰，同时确保蛋白质被有效表达和加工并保持所需的结构特征，并设计基因 其核苷酸序列类似于宿主载体基因组的基本组成。