公开(公告)号：EP3331858A1

公开(公告)日：2018-06-13

申请号：EP16759907.5

申请日：2016-08-05

申请人： Arnér, Elias, Set Jenö ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： STAFFORD, William, Chester ,  COUSSENS, Nathan, Patrick ,  LUCI, Diane, Karen ,  MALONEY, David, Joseph ,  SIMEONOV, Anton ,  JADHAV, Ajit ,  DEXHEIMER, Thomas, S. ,  ARNÉR, Elias Set Jenö

IPC分类号： C07D213/71 ,  A61P35/00 ,  A61K31/435

CPC分类号： C07D213/71

摘要： There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3, R4 and n have meanings provided in the description, which compounds are useful in the treatment of cancers.

公开(公告)号：EP3331883A1

公开(公告)日：2018-06-13

申请号：EP16751126.0

申请日：2016-08-05

申请人： Arnér, Elias, Set Jenö ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： STAFFORD, William, Chester ,  COUSSENS, Nathan, Patrick ,  LUCI, Diane, Karen ,  MALONEY, David, Joseph ,  SIMEONOV, Anton ,  JADHAV, Ajit ,  DEXHEIMER, Thomas, S. ,  ARNÉR, Elias, Set Jenö

IPC分类号： C07D471/18 ,  A61K31/407 ,  A61P35/00

CPC分类号： C07D471/18

摘要： There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein X, Y, Z, R1 and R2 have meanings provided in the description, which compounds are useful in the treatment of cancers.

公开(公告)号：EP3331878A1

公开(公告)日：2018-06-13

申请号：EP16751125.2

申请日：2016-08-05

申请人： Arnér, Elias, Set Jenö ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： STAFFORD, William, Chester ,  COUSSENS, Nathan, Patrick ,  LUCI, Diane, Karen ,  MALONEY, David, Joseph ,  SIMEONOV, Anton ,  JADHAV, Ajit ,  DEXHEIMER, Thomas, S. ,  ARNÉR, Elias, Set Jenö

IPC分类号： C07D413/06 ,  A61K31/501 ,  A61P35/00

CPC分类号： C07D413/06

摘要： There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein W, X, Y, Z, R1, R2 and R3 have meanings provided in the description, which compounds are useful in the treatment of cancers.