公开(公告)号：EP1507531A2

公开(公告)日：2005-02-23

申请号：EP04720451.6

申请日：2004-03-12

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： TOTH, Zoltan G. ,  GYOLLAI, Viktor ,  KOVACSNE-MEZEI, Adrienne ,  SZABO, Csaba ,  ARONHIME, Judith ,  SINGER, Claude

IPC分类号： A61K31/4545 ,  A61P37/06

CPC分类号： C07D401/04 ,  A61K31/4545

摘要： Provided is a stable pharmaceutical composition of desloratadine.

公开(公告)号：EP1481674A1

公开(公告)日：2004-12-01

申请号：EP04010770.8

申请日：2000-11-28

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： Keri, Vilmos ,  Deak, Lajos ,  Forgacs, Ilona ,  Szabo, Csaba ,  Nagyne, Edit Arvai

IPC分类号： A61K31/215

CPC分类号： C07C67/52 ,  C07C67/58 ,  C07C2602/28 ,  C07C69/33

摘要： Process for isolating/purifying pravastatin sodium by solvent extraction, using esters and aqueous solutions.

公开(公告)号：EP1357918A2

公开(公告)日：2003-11-05

申请号：EP02717362.4

申请日：2002-01-09

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： BAKONDI-KOVACS, Istvan ,  NOVOTNY, Iiona, Csutoros ,  ERDEI, Janos ,  BALOGH, Gabor ,  SERESS, Peter

IPC分类号： A61K31/70

CPC分类号： C12P19/26

摘要： A metabolic controlled fermentation process has been developed for the production of carbamoyl tobramycin by the application of different Streptocmyces tenebrarius strains in submerged cultures at a temperature within about 37-41°C on a medium containing assimilable carbon and nitrogen sources, mineral salts and controlling the assimilable carbon and nitrogen sources by feeding in an optimal range. As a result of this invention a high yield production of carbamoyl tobramycin with high purity could be achieved.

公开(公告)号：EP1330245A1

公开(公告)日：2003-07-30

申请号：EP01979511.1

申请日：2001-10-05

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： KERI, Vilmos ,  DEAK, Lajos ,  FORGACS, Ilona ,  SZABO, Csaba ,  NAGYNE, Arvai, Edit

IPC分类号： A61K31/19 ,  A61K31/225

CPC分类号： C07D309/38 ,  A61K31/225 ,  A61K31/365 ,  C07C67/52 ,  C07C69/33

摘要： The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.

公开(公告)号：EP1265884A1

公开(公告)日：2002-12-18

申请号：EP01913139.0

申请日：2001-02-27

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： KERI, Vilmos ,  FORGAS, Ilona

IPC分类号： C07D311/00 ,  C07C69/74

CPC分类号： C07D309/30

摘要： A process reducing the levels of dimeric impurities in a statin to less than 0.08 % by treatment of a statin containing more than 0.08 % dimeric impurities with a mild base in a suitable solvent mixture.

公开(公告)号：EP0930879A2

公开(公告)日：1999-07-28

申请号：EP97952124.0

申请日：1997-12-30

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： VOJCEK, Lászlo ,  BEDÖ, Tibor ,  POK, Tibor ,  BARTOK, Gábor ,  AGNI, Zsolt

IPC分类号： A61K31 ,  A61P5

CPC分类号： A61K31/185

摘要： Subject of the invention is a molecule characterised by general structure (1), where meaning of x: 1 or 2 valency metallic ion adequate from therapeutic point of view, value of n: 1 or 2, or the application of its metabolite being suitable for the treatment or prevention of embryonic retardation or discordance.

公开(公告)号：EP0712631A2

公开(公告)日：1996-05-22

申请号：EP95106655.4

申请日：1995-05-03

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： Kovacs, Istvan ,  Jusztin, Marta ,  Takacs, Erzsébet ,  Balazs, Zoltan ,  Kiss, Ildiko ,  Varga, Zsolt ,  Jancso, Sandor ,  Heim, Csaba ,  Kanya Korcsmaros, Ildiko ,  Erdöhati, Erzsébet ,  Jarabin, Marta

IPC分类号： A61K38/13 ,  A61K9/113

CPC分类号： A61K9/4858 ,  A61K9/113 ,  A61K38/13 ,  Y10S514/885 ,  Y10S514/935 ,  Y10S514/937

摘要： The invention relates to an oral multiple emulsion pre concentrate comprising a surface active agent, ethanol a lipophilic and/or an amphiphilic solvent. The composition comprising from about 5 to about 30 % by weight of cyclosporin, from about 5 to about 30 % by weigh of tocopheryl polyethylene glycol carboxylic acid ester, from about 5 to about 20 % by weight of ethanol, from about 20 to about 55 % by weight of a lipophylic solvent and/or from about 10 to about 55 % by weight of an amphiphilic solvent, and if desired from about 10 to about 20 % by weight of co-tenside.

摘要翻译： 本发明涉及包含表面活性剂，乙醇，亲脂性和/或两亲性溶剂的口腔多重乳液预浓缩物。 该组合物包含约5至约30重量％的环孢菌素，约5至约30重量％的生育酚聚乙二醇羧酸酯，约5至约20重量％的乙醇，约20至约55 重量％的亲脂性溶剂和/或约10至约55％重量的两亲性溶剂，如果需要，约10至约20％重量的共表面活性剂。

公开(公告)号：EP0576792A2

公开(公告)日：1994-01-05

申请号：EP93105848.1

申请日：1993-04-13

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： Ott, István, Dr. ,  Klupp, Tibor, Dr. ,  Molnár, István ,  Patthy, András, Dr. ,  Barta, István ,  Berk -T th, Zsuzsa, Ir.-Chem. ,  Ambrus, Gábor, Dr. Ir.-Chem. ,  Salát, János ,  Tegdes, Anik ,  Moravcsik, Imre, Ir.-Chem. ,  Együd, Cecilia ,  Albrecht, Károly ,  Könczöl, Kálmán, Dr. Ir.-Chem. ,  Vincze, Attila ,  Barabás, Eva, Dr. ,  Máté, György, Ir.-Chem. ,  Botond Kiss, György Dr. ,  Kiss, Péter ,  Pölya, Kálmán, Dr. ,  Erdei, Janos Dr. ,  Erdei, Jan s Dr. ,  Zilahi, Erika

IPC分类号： C12N15/15

CPC分类号： C07K14/815 ,  A61K38/00 ,  C07K2319/00 ,  C12N15/76

摘要： The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms.
Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with isolated promoters and signal sequences, subsequently the expression/secretion cassettes comprising the foregoing elements were inserted into plasmid DNAs allowing the cultivation of cells under selective culture conditions. E. coli, Saccharomyces and Streptomyces species were transformed with the said recombinant plasmids to biosynthesize the thrombin inhibitor desulphatohirudin HV-1 which was then isolated and identified.
The thus-produced desulphatohirudin can be used to inhibit blood coagulation.

摘要翻译： 本发明涉及通过培养微生物生产重组脱硫水蛭素的方法。 关于微生物的密码子使用，合成的核苷酸序列在分离的启动子和信号序列的下游和阅读框架中连接，随后将包含前述元件的表达/分泌盒插入允许在选择性培养条件下培养细胞的质粒DNA。 用所述重组质粒转化大肠杆菌，酵母属和链霉菌物种以生物合成凝血酶抑制剂脱硫水蛭素HV-1，然后分离和鉴定。 由此产生的脱硫水蛭素可用于抑制血液凝固。

公开(公告)号：EP1539752A1

公开(公告)日：2005-06-15

申请号：EP03771977.0

申请日：2003-07-28

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： MERLI, Valeriano ,  BIANCHI, Stefano ,  MANTOVANI, Silvia

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4- carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo [4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4- carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo [4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.

公开(公告)号：EP1523978A2

公开(公告)日：2005-04-20

申请号：EP05000980.2

申请日：2000-12-14

申请人： BIOGAL GYOGYSZERGYAR RT.

发明人： Keri, Vilmos ,  Szabo, Csaba ,  Arvai, Edit Nagyne ,  Aronhime, Judith

IPC分类号： A61K9/14 ,  C07C69/33 ,  C07C67/52

CPC分类号： C07C69/33 ,  C07C67/52 ,  C07C2602/28

摘要： New polymorphic forms of pravastatin sodium are provided. Each of the new forms is selectively obtained by crystallization from different solvent systems, each solvent system having a protic component, and by controlling the rate of crystallization through temperature. The new polymorphic forms are suitable for use as active substances of pharmaceutical dosage forms for reduction of serum cholesterol levels in the bloodstream.

摘要翻译： 提供了普伐他汀钠的新型多晶型物质。 通过从不同的溶剂体系结晶，每种溶剂体系具有质子成分，并通过控制通过温度的结晶速率来选择性地获得每种新形式。 新的多晶型适用于药物剂型的活性物质，用于降低血液中的血清胆固醇水平。