公开(公告)号：EP2826371A3

公开(公告)日：2015-12-30

申请号：EP14173546.4

申请日：2008-11-23

申请人： Biomas Ltd.

发明人： Albeck, Michael ,  Sredni, Benjamin

IPC分类号： A01N59/16 ,  A61K31/33

CPC分类号： C07D517/22 ,  A61K31/095 ,  A61K31/33 ,  A61K31/555 ,  A61K45/06 ,  C07D329/00 ,  Y02A50/393

摘要： Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of 5 Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an antineoplastic agent and by a high level of expression of an integrin by neoplastic cells.

摘要翻译： 公开了使用含碲化合物来抑制整联蛋白和治疗整联蛋白相关病症的组合物和方法。 含碲化合物包含至少一个碲二氧部分并且可以具有如说明书中所定义的5个式I至IV中的任一个。 进一步公开了用于治疗以抗肿瘤剂抗性为特征的肿瘤性病症和由赘生性细胞高水平表达整联蛋白的组合物和方法。

公开(公告)号：EP2385757A4

公开(公告)日：2012-12-26

申请号：EP10729144

申请日：2010-01-07

申请人： BIOMAS LTD

发明人： SREDNI BENJAMIN ,  ALBECK MICHAEL ,  RON BENJAMIN

IPC分类号： A01N31/00 ,  A61K31/095 ,  A61P15/08

CPC分类号： A61K45/06 ,  A61K31/095 ,  A61K33/04 ,  A61K2300/00

公开(公告)号：EP1802292A4

公开(公告)日：2008-02-13

申请号：EP05784166

申请日：2005-09-15

申请人： BIOMAS LTD

发明人： ALBECK MICHAEL ,  SREDNI BENJAMIN

IPC分类号： A61K31/555 ,  A61K45/06 ,  C07C395/00

CPC分类号： A61K45/06 ,  A61K31/555 ,  C07C395/00 ,  C07F11/005 ,  A61K2300/00

摘要： Novel tellurium-containing compounds and uses thereof as immunomodulators are disclosed.

公开(公告)号：EP1791535A2

公开(公告)日：2007-06-06

申请号：EP05779419.0

申请日：2005-09-15

申请人： BioMAS Ltd.

发明人： ALBECK, Michael ,  SREDNI, Benjamin

IPC分类号： A61K31/28 ,  A61P37/02 ,  C07F11/00

CPC分类号： A61K45/06 ,  A61K31/555 ,  C07C395/00 ,  C07F11/005 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  A61K2300/00

摘要： Novel tellurium-containing compounds and uses thereof as immunomodulators are disclosed.

公开(公告)号：EP2826371A2

公开(公告)日：2015-01-21

申请号：EP14173546.4

申请日：2008-11-23

申请人： Biomas Ltd.

发明人： Albeck, Michael ,  Sredni, Benjamin

IPC分类号： A01N59/16 ,  A61K31/33

CPC分类号： C07D517/22 ,  A61K31/095 ,  A61K31/33 ,  A61K31/555 ,  A61K45/06 ,  C07D329/00 ,  Y02A50/393

摘要： Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of 5 Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an antineoplastic agent and by a high level of expression of an integrin by neoplastic cells.

摘要翻译： 组合物和方法用于治疗抑制整合素和整合素相关的条件，利用含碲化合物是游离缺失盘。 含碲化合物包含至少一种碲二氧部分，并且可以具有5之一的任何式I至IV如说明书中所定义。 进一步游离缺失盘是组合物和方法用于治疗处于抗肿瘤剂通过电阻表征为肿瘤性转化状态，并通过由赘生性细胞高水平整的表达。

公开(公告)号：EP1715785B1

公开(公告)日：2014-03-26

申请号：EP05703127.0

申请日：2005-01-23

申请人： Biomas Ltd.

发明人： SREDNI, Benjamin ,  ALBECK, Michael

IPC分类号： A61K33/04 ,  A61P17/00

CPC分类号： A61K33/04 ,  A61K9/0014 ,  A61K31/095 ,  A61K31/555 ,  A61K45/06 ,  A61K47/06 ,  A61K47/20

摘要： A novel method for treating skin and mucosal membrane ailments caused by human papilloma viruses, which utilizes tellurium-containing compounds, is disclosed. Also disclosed are pharmaceutical compositions containing tellurium-containing compounds for treating such ailments.

公开(公告)号：EP2385758A4

公开(公告)日：2013-01-23

申请号：EP10729145

申请日：2010-01-07

申请人： BIOMAS LTD ,  TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES LTD

发明人： SREDNI BENJAMIN ,  MEIROW DROR ,  ALBECK MICHAEL ,  RON BENJAMIN

IPC分类号： A01N31/00 ,  A61K31/095 ,  A61K33/04 ,  A61P15/08

CPC分类号： A61K31/095 ,  A61K33/04 ,  A61K41/00 ,  A61K2300/00

公开(公告)号：EP2222167A4

公开(公告)日：2011-01-05

申请号：EP08852795

申请日：2008-11-23

申请人： BIOMAS LTD

发明人： SREDNI BENJAMIN ,  ALBECK MICHAEL

IPC分类号： A01N59/16 ,  A61K31/33

CPC分类号： C07D517/22 ,  A61K31/095 ,  A61K31/33 ,  A61K31/555 ,  A61K45/06 ,  C07D329/00

摘要： Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of 5 Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an antineoplastic agent and by a high level of expression of an integrin by neoplastic cells.

公开(公告)号：EP2222167A2

公开(公告)日：2010-09-01

申请号：EP08852795.7

申请日：2008-11-23

申请人： Biomas Ltd.

发明人： SREDNI, Benjamin ,  ALBECK, Michael

IPC分类号： A01N59/16 ,  A61K31/33

CPC分类号： C07D517/22 ,  A61K31/095 ,  A61K31/33 ,  A61K31/555 ,  A61K45/06 ,  C07D329/00 ,  Y02A50/393

摘要： Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of 5 Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an antineoplastic agent and by a high level of expression of an integrin by neoplastic cells.

公开(公告)号：EP1924254A2

公开(公告)日：2008-05-28

申请号：EP06796089.8

申请日：2006-09-14

申请人： Biomas Ltd.

发明人： SREDNI, Benjamin ,  ALBECK, Michael

IPC分类号： A61K31/33

CPC分类号： A61K31/33

摘要： Methods for treating skin conditions such as basal cell carcinoma and/or actinic keratosis are provided, which are effected by administering a pharmaceutically effective amount of a tellurium-containing compound. A pharmaceutical composition for treatment of skin conditions such as basal cell carcinoma an/or actinic keratosis is also provided.