NG2/HM PROTEOGLYCAN-BINDING PEPTIDES THAT HOME TO ANGIOGENIC VASCULATURE AND RELATED METHODS
    7.
    发明公开
    NG2/HM PROTEOGLYCAN-BINDING PEPTIDES THAT HOME TO ANGIOGENIC VASCULATURE AND RELATED METHODS 审中-公开
    船舶血管新生具体NG2 / HM蛋白多糖结合肽及相关方法

    公开(公告)号:EP1161149A4

    公开(公告)日:2002-04-10

    申请号:EP00908659

    申请日:2000-02-16

    申请人: BURNHAM INST

    CPC分类号: C07K7/06 A61K38/00

    摘要: The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID NO:1) or LTLRWVGLMS (SEQ ID NO:2). The invention also provides conjugates comprising an angiogenic vasculature homing molecule linked to a moiety such as a drug, a cytotoxic agent, a chemotherapeutic agent, or a detectable agent. The invention additionally provides a method of targeting angiogenic vasculature in a tumor in vivo by contacting the angiogenic vasculature with an angiogenic vasculature homing molecule that selectively homes to a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody. The invention additionally provides a method of inhibiting angiogenesis in a tumor of a subject by administering to the subject a conjugate comprising a moiety linked to an angiogenic vasculature homing molecule that selectively binds a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody.