公开(公告)号：EP1465888A2

公开(公告)日：2004-10-13

申请号：EP03708824.2

申请日：2003-01-09

申请人： NEUROGEN CORPORATION ,  De Simone, Robert ,  Peterson, John ,  Steenstra, Cheryl ,  Shen, Yiping ,  Gustavson, Linda ,  Bakthavatchalam, Rajagopal ,  Hutchison, Alan

发明人： DE SIMONE, Robert ,  PETERSON, John ,  STEENSTRA, Cheryl ,  SHEN, Yiping ,  GUSTAVSON, Linda ,  BAKTHAVATCHALAM, Rajagopal ,  HUTCHISON, Alan

IPC分类号： C07D401/10 ,  C07D401/14 ,  A61K31/454

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D235/14 ,  C07D249/08 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D513/04

摘要： Melanin concentrating hormone receptor ligands (especially substituted benzoimidazole analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).