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    COMPOUND CONTAINING INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF
    1.
    发明公开
    COMPOUND CONTAINING INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF 审中-公开
    含有吲哚乙酸核心结构的化合物及其用途

    公开(公告)号：EP3252039A1

    公开(公告)日：2017-12-06

    申请号：EP16742705.3

    申请日：2016-01-25

    申请人： Beijing An Jian Xi Bio-Medical Technology Co., Ltd

    发明人： Beijing An Jian Xi Bio-Medical Technology Co., Ltd

    IPC分类号： C07D209/26 ,  C07C317/44 ,  A61K31/405 ,  A61K31/216 ,  A61P35/00 ,  A61P35/02 ,  A61P29/00

    CPC分类号： C07D209/26 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/216 ,  A61K31/337 ,  A61K31/405 ,  A61K31/635 ,  A61K31/661 ,  A61K31/704 ,  A61K45/06 ,  C07C317/44 ,  C07C2602/08

    摘要： Disclosed are a compound as shown by the following formula 1, and a pharmaceutically acceptable salt, an ester, a hydrate and an organic solvate thereof. In the formula (1), the groups R 1 to R 17 are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, carbonyl, hydroxyl, amino, azido, carboxyl and C 1 -C 8 alkylsulfinyl, respectively; and X is a carbon or nitrogen atom; Y is selected from the following groups: a single bond, C 1 -C 8 alkylene, C 6 -C 20 arylene and C 4 -C 20 heteroarylene; and n is an integer from 5 to 20. Also provided in the present invention are a pharmaceutical composition containing the compound, and use thereof in the field of tumor therapy.

    摘要翻译： 公开了如下式1所示的化合物及其药学上可接受的盐，酯，水合物和有机溶剂化物。 在式（1）中，基团R 1至R 17独立地选自氢，氟，氯，溴，碘，C 1 -C 8烷基，C 1 -C 8烷氧基，羰基，羟基，氨基，叠氮基，羧基和 C1-C8烷基亚磺酰基; X是碳或氮原子; Y选自以下基团：单键，C1-C8亚烷基，C6-C20亚芳基和C4-C20杂亚芳基; n为5-20的整数。本发明还提供了含有该化合物的药物组合物及其在肿瘤治疗领域的用途。