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公开(公告)号：EP3502142A1
公开(公告)日：2019-06-26
申请号：EP17814712.0
申请日：2017-06-21
发明人： YU, Haoyang , WANG, Zhong , LI, Zhengcheng
摘要： Provided in the present invention is a bispecific antibody which comprises an antibody fragment of anti-MUC1 VHH and an antibody fragment of anti-CD 16 VHH. The antibody fragment used in the present invention is a variable region sequence derived from a heavy chain camelid antibody and has a high binding affinity to the antigen. Antibody fragments recognizing MUC1 and CD16 are constructed in the same antibody molecule by the invention, so that the antibody molecule can specifically bind to MUC1 and CD16 molecules to promote the killing effect of NK cells on MUC1-positive expression cells and has an inhibiting effect on the growth of MUC1-positive tumors. Also provided is a conjugate of the bispecific antibodies, a related pharmaceutical composition and use.
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公开(公告)号：EP3450460A1
公开(公告)日：2019-03-06
申请号：EP16900170.8
申请日：2016-10-13
发明人： YU, Haoyang , LI, Zhengcheng , SU, Jing
摘要： The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).
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公开(公告)号：EP4245775A3
公开(公告)日：2023-11-15
申请号：EP23181122.5
申请日：2016-10-13
发明人： Yu, Haoyang , Li, Zhengcheng , Su, Jing
摘要： The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).
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公开(公告)号：EP4245775A2
公开(公告)日：2023-09-20
申请号：EP23181122.5
申请日：2016-10-13
发明人： Yu, Haoyang , Li, Zhengcheng , Su, Jing
摘要： The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).
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公开(公告)号：EP4385572A2
公开(公告)日：2024-06-19
申请号：EP24172423.6
申请日：2016-04-14
发明人： YU, Haoyang , LI, Zhengcheng , SU, Jing
IPC分类号： A61P35/00
CPC分类号： A61K39/44 , C07K16/2815 , C07K16/3069 , C07K16/32 , A61K2039/50520130101 , A61K2039/50720130101 , C07K2317/7320130101 , A61K47/6849 , A61K47/6851 , A61K47/6935 , A61K47/6937 , C07K16/2803 , C07K16/2809 , C07K16/2887 , C07K16/3092 , C07K2317/3120130101 , A61P35/00
摘要： The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.
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公开(公告)号：EP3599250A1
公开(公告)日：2020-01-29
申请号：EP18744269.4
申请日：2018-01-23
发明人： YU, Haoyang , WANG, Zhong , LI, Zhengcheng
IPC分类号： C07K17/08 , C07K16/46 , A61K39/44 , A61K47/59 , A61K47/60 , A61P35/00 , A61P37/02 , A61P29/00
摘要： The present invention relates to a multi-specific antibody conjugate (such as, a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody, such as a bispecific antibody, conjugated to a nanomaterial. The antibody conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease), etc..
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7.发明公开
公开(公告)号：EP3290440A1
公开(公告)日：2018-03-07
申请号：EP16779607.7
申请日：2016-04-14
发明人： YU, Haoyang , LI, Zhengcheng , SU, Jing
CPC分类号： A61K47/593 , A61K39/44 , A61K47/6849 , A61K47/6851 , A61K47/6935 , A61K47/6937 , A61K2039/505 , A61K2039/507 , C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2887 , C07K16/3069 , C07K16/3092 , C07K16/32 , C07K2317/31 , C07K2317/73
摘要： The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.
摘要翻译： 本发明提供了一种能够与免疫细胞结合以增强靶向肿瘤杀伤能力的双特异性抗体及其制备方法及其应用。 通过化学方法连接抗体和可降解纳米粒子，使得一个纳米粒子同时与两个或更多个抗体分子连接，其中一个抗体可以与免疫细胞特异性结合，另一个抗体或另一个抗体 抗体可以与肿瘤细胞特异性结合，从而达到提高免疫细胞以靶向方式特异性杀伤肿瘤细胞的能力的效果。
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