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公开(公告)号：EP3502142A1
公开(公告)日：2019-06-26
申请号：EP17814712.0
申请日：2017-06-21
发明人： YU, Haoyang , WANG, Zhong , LI, Zhengcheng
摘要： Provided in the present invention is a bispecific antibody which comprises an antibody fragment of anti-MUC1 VHH and an antibody fragment of anti-CD 16 VHH. The antibody fragment used in the present invention is a variable region sequence derived from a heavy chain camelid antibody and has a high binding affinity to the antigen. Antibody fragments recognizing MUC1 and CD16 are constructed in the same antibody molecule by the invention, so that the antibody molecule can specifically bind to MUC1 and CD16 molecules to promote the killing effect of NK cells on MUC1-positive expression cells and has an inhibiting effect on the growth of MUC1-positive tumors. Also provided is a conjugate of the bispecific antibodies, a related pharmaceutical composition and use.
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公开(公告)号：EP3599250A1
公开(公告)日：2020-01-29
申请号：EP18744269.4
申请日：2018-01-23
发明人： YU, Haoyang , WANG, Zhong , LI, Zhengcheng
IPC分类号： C07K17/08 , C07K16/46 , A61K39/44 , A61K47/59 , A61K47/60 , A61P35/00 , A61P37/02 , A61P29/00
摘要： The present invention relates to a multi-specific antibody conjugate (such as, a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody, such as a bispecific antibody, conjugated to a nanomaterial. The antibody conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease), etc..
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