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1.发明授权FUNKTIONELLE VITAMIN-D-DERIVATE UND VERFAHREN ZUR BESTIMMUNG VON 25-HYDROXY- UND 1ALPHA,25-DIHYDROXY-VITAMIN-D 有权功能性维生素D衍生物和方法的25-羟基测定及1α的，25二羟基维生素D
公开(公告)号：EP1097132B1
公开(公告)日：2003-12-17
申请号：EP99932730.7
申请日：1999-06-25
申请人： Immundiagnostik Gesellschaft für Produktion und Vertrieb von Labordiagnostika mbH , Biomedica GmbH
IPC分类号： C07C401/00
CPC分类号： G01N33/82
摘要： The invention relates to a multifunctional vitamin D derivative of formula (I) wherein; O represents the oxygen atom of an ether group; X represents a spacer group having a length of 0.8 to 4.2 nm, for example, an amino carboxylic acid radical, an amino undecanoic acid radical, or an amino polyether radical; Y represents hydrogen or hydroxy; A represents a tracer group such as biotin, digoxygenin or another vitamin D group which are bound by a protein having a higher affinity; R represents a hydrocarbon side-group of vitamin D or vitamin D metabolites. The invention also relates to a method for quantitatively determining a 25-hydroxy-vitamin D metabolite and a 1 alpha ,25-dihydroxy-vitamin D metabolite in a sample.
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2.发明公开FUNKTIONELLE VITAMIN-D-DERIVATE UND VERFAHREN ZUR BESTIMMUNG VON 25-HYDROXY- UND 1ALPHA,25-DIHYDROXY-VITAMIN-D 有权功能性维生素D衍生物和方法的25-羟基测定及1α的，25二羟基维生素D
公开(公告)号：EP1097132A1
公开(公告)日：2001-05-09
申请号：EP99932730.7
申请日：1999-06-25
申请人： ImmundiagnostikGesellschaft für Produktion und Vertrieb von Labordiagnostika mbH , Biomedica GmbH
IPC分类号： C07C401/00
CPC分类号： G01N33/82
摘要： The invention relates to a multifunctional vitamin D derivative of formula (I) wherein; O represents the oxygen atom of an ether group; X represents a spacer group having a length of 0.8 to 4.2 nm, for example, an amino carboxylic acid radical, an amino undecanoic acid radical, or an amino polyether radical; Y represents hydrogen or hydroxy; A represents a tracer group such as biotin, digoxygenin or another vitamin D group which are bound by a protein having a higher affinity; R represents a hydrocarbon side-group of vitamin D or vitamin D metabolites. The invention also relates to a method for quantitatively determining a 25-hydroxy-vitamin D metabolite and a 1α,25-dihydroxy-vitamin D metabolite in a sample.
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