专利检索 ap:"ImmundiagnostikGesellschaft für Produktion und Vertrieb von Labordiagnostika mbH" 第 1 页

1.

发明公开
FUNKTIONELLE VITAMIN-D-DERIVATE UND VERFAHREN ZUR BESTIMMUNG VON 25-HYDROXY- UND 1ALPHA,25-DIHYDROXY-VITAMIN-D 有权
标题翻译：功能性维生素D衍生物和方法的25-羟基测定及1α的，25二羟基维生素D

公开(公告)号：EP1097132A1

公开(公告)日：2001-05-09

申请号：EP99932730.7

申请日：1999-06-25

申请人： ImmundiagnostikGesellschaft für Produktion und Vertrieb von Labordiagnostika mbH , Biomedica GmbH

发明人： ARMBRUSTER, Franz, Paul , VOELTER, Wolfgang , SCHWING, Jens , BIRKMAYER, Christian

IPC分类号： C07C401/00

CPC分类号： G01N33/82

摘要： The invention relates to a multifunctional vitamin D derivative of formula (I) wherein; O represents the oxygen atom of an ether group; X represents a spacer group having a length of 0.8 to 4.2 nm, for example, an amino carboxylic acid radical, an amino undecanoic acid radical, or an amino polyether radical; Y represents hydrogen or hydroxy; A represents a tracer group such as biotin, digoxygenin or another vitamin D group which are bound by a protein having a higher affinity; R represents a hydrocarbon side-group of vitamin D or vitamin D metabolites. The invention also relates to a method for quantitatively determining a 25-hydroxy-vitamin D metabolite and a 1α,25-dihydroxy-vitamin D metabolite in a sample.