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公开(公告)号：EP2958134B1
公开(公告)日：2019-05-08
申请号：EP15169775.2
申请日：2015-05-29
发明人： Park, Melvin A.
IPC分类号： H01J49/40
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公开(公告)号：EP3745123A1
公开(公告)日：2020-12-02
申请号：EP20176076.6
申请日：2020-05-22
发明人： PARK, Melvin
摘要： The invention provides hybrid mass spectrometric systems which comprise an ion source, a first trapped ion mobility spectrometry (TIMS) analyzer and a mass analyzer, wherein the TIMS analyzer is located and operated in a first vacuum chamber at an elevated pressure above 500 Pa, and methods for operating the hybrid mass spectrometric systems.
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4.发明公开
公开(公告)号：EP3578966A1
公开(公告)日：2019-12-11
申请号：EP19174724.5
申请日：2019-05-15
发明人： RIDGEWAY, Mark
摘要： Method for targeted analysis of ions according to mobility which uses a trapping ion mobility separator (TIMS) comprising a gas flow and an electric DC field barrier within an RF ion guide. The method comprises the steps of introducing ions into the trapping ion mobility separator, pushing the ions by the gas flow against the counteracting electric DC field barrier wherein the height of the electric DC field barrier and the velocity of the gas flow are set such that target ions are trapped near a plateau of the trapping ion mobility separator along which the effective force acting on the ions is substantially constant, and adjusting the height of the electric DC field barrier and/or the velocity of the gas flow in a single step such that the target ions pass the electric DC field barrier.
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公开(公告)号：EP3736566A1
公开(公告)日：2020-11-11
申请号：EP20182538.7
申请日：2019-02-22
摘要： The invention proposes methods and devices for tandem ion mobility spectrometry using at least one trapping ion mobility spectrometry (TIMS) analyzers, in particular in the field of structural biology.
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公开(公告)号：EP3531122B1
公开(公告)日：2020-08-19
申请号：EP19158744.3
申请日：2019-02-22
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公开(公告)号：EP3570313A2
公开(公告)日：2019-11-20
申请号：EP19166703.9
申请日：2019-04-02
发明人： MUNTEAN, Felician , Steiner, Urs
摘要： The invention relates to mass spectrometers having secondary electron multipliers with series of discrete dynode stages. The invention particularly relates to an operation with extended dynamic measuring range and extended lifetime. The invention is based on not adapting the dynamic measuring range by control of the gain of the trans-impedance amplifier, nor controlling the multiplier operating voltage, which both are usually too slow, but alternating a number of active and passive dynode stages of a discrete dynode multiplier. Each dynode stage is connected to a discrete voltage supply circuit, being able to be de-energized and short-cut; the multiplier gain is feedback-controlled by energizing or short-cutting dynode stages, serially from the end of the multiplier, as a function of a last measured ion signal; and the multiplier has a single trans-impedance amplifier and a single analog-to-digital converter, measuring and digitizing the output current of the last active dynode stage.
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公开(公告)号：EP3531122A1
公开(公告)日：2019-08-28
申请号：EP19158744.3
申请日：2019-02-22
摘要： The invention proposes methods and devices for tandem ion mobility spectrometry using at least one trapping ion mobility spectrometry (TIMS) analyzer, in particular in the field of structural biology.
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公开(公告)号：EP3832310A1
公开(公告)日：2021-06-09
申请号：EP20207874.7
申请日：2020-11-16
发明人： Easterling, Michael
IPC分类号： G01N33/68 , G01N27/622
摘要： A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.
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公开(公告)号：EP3570313A3
公开(公告)日：2020-03-18
申请号：EP19166703.9
申请日：2019-04-02
发明人： MUNTEAN, Felician , Steiner, Urs
摘要： The invention relates to mass spectrometers having secondary electron multipliers with series of discrete dynode stages. The invention particularly relates to an operation with extended dynamic measuring range and extended lifetime. The invention is based on not adapting the dynamic measuring range by control of the gain of the trans-impedance amplifier, nor controlling the multiplier operating voltage, which both are usually too slow, but alternating a number of active and passive dynode stages of a discrete dynode multiplier. Each dynode stage is connected to a discrete voltage supply circuit, being able to be de-energized and short-cut; the multiplier gain is feedback-controlled by energizing or short-cutting dynode stages, serially from the end of the multiplier, as a function of a last measured ion signal; and the multiplier has a single trans-impedance amplifier and a single analog-to-digital converter, measuring and digitizing the output current of the last active dynode stage.
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