公开(公告)号：EP0934593A4

公开(公告)日：2001-10-24

申请号：EP97948134

申请日：1997-10-28

申请人： CARDIOTRONICS SYSTEMS INC

发明人： PERRAULT JAMES J

IPC分类号： A01N25/10 ,  A01N33/12 ,  A01N37/12 ,  A01N37/20 ,  A61B5/0408 ,  A61K9/00 ,  A61K31/785 ,  A61K47/32 ,  A61L15/46 ,  A61L15/60 ,  C08F20/34 ,  C08F20/60 ,  C08L33/00 ,  H01B1/12 ,  H01B1/00 ,  A61B5/04 ,  A61K9/10 ,  A61K9/14 ,  A61N1/04 ,  C09J9/02 ,  H01B1/04 ,  H01B1/06

CPC分类号： A61K9/0014 ,  A01N25/10 ,  A01N33/12 ,  A01N37/12 ,  A01N37/20 ,  A61B5/04087 ,  A61K9/0009 ,  A61K31/785 ,  A61K47/32 ,  C08F20/34 ,  C08F20/60 ,  H01B1/122 ,  Y10S514/944 ,  A01N2300/00

摘要： A composition providing electrically conductive adhesive hydrogels used as skin contact adhesives and an electrical interface for disposable medical devices. The hydrogels are cationic acrylates and are made from acrylic esters of quaternary chlorides and/or sulfates or acrylic amides of quaternary chlorides. The present hydrogels are formed by free radical polymerization in the presence of water by ultraviolet curing with initiator and multifunctional cross-linking agent, and include a buffer system to prevent discoloration, hydrolysis of and improve shelf-life of the hydrogels. Other additives may be added to the hydrogels either before or after curing, depending on the intended end use. The present hydrogels hydrate a subject's skin, wet around skin surface hair and protect against burning of a subject due to electrical stimulation through the hydrogel. The hydrogels, cohesiveness enables direct hydrogel-to-hydrogel contact and storage, yet remain readily separable. The hydrogels may be presented in a formula which is noncorrosive to aluminum in contact therewith, and pass standards testing for biocompatibility and electrical properties.

摘要翻译： 提供用作皮肤接触粘合剂的导电粘合剂水凝胶和用于一次性医疗装置的电接口的组合物。 水凝胶是阳离子丙烯酸酯，并且由四元氯化物和/或硫酸酯的丙烯酸酯或季氯化物的丙烯酰胺制成。 本发明的水凝胶通过在引发剂和多功能交联剂的紫外线固化下在水存在下通过自由基聚合形成，并且包括缓冲体系以防止水凝胶的变色，水解和提高保质期。 取决于预期的最终用途，可以在固化之前或之后将其他添加剂加入到水凝胶中。 本发明的水凝胶水合受试者的皮肤，润湿皮肤表面的毛发并防止由于通过水凝胶的电刺激而使受试者燃烧。 水凝胶，凝聚性使得直接的水凝胶与水凝胶的接触和储存成为可能，但仍然容易分离。 水凝胶可以以与其接触的铝无腐蚀性的配方呈现，并且通过用于生物相容性和电特性的标准测试。

公开(公告)号：EP0934593A1

公开(公告)日：1999-08-11

申请号：EP97948134.0

申请日：1997-10-28

申请人： Cardiotronics Systems, Inc.

发明人： PERRAULT, James, J.

IPC分类号： A01N25 ,  A01N33 ,  A01N37 ,  A61B5 ,  A61K9 ,  A61K31 ,  A61K47 ,  A61L15 ,  C08F20 ,  C08L33 ,  H01B1

CPC分类号： A61K9/0014 ,  A01N25/10 ,  A01N33/12 ,  A01N37/12 ,  A01N37/20 ,  A61B5/04087 ,  A61K9/0009 ,  A61K31/785 ,  A61K47/32 ,  C08F20/34 ,  C08F20/60 ,  H01B1/122 ,  Y10S514/944 ,  A01N2300/00

摘要： A composition providing electrically conductive adhesive hydrogels used as skin contact adhesives and an electrical interface for disposable medical devices. The hydrogels are cationic acrylates and are made from acrylic esters of quaternary chlorides and/or sulfates or acrylic amides of quaternary chlorides. The present hydrogels are formed by free radical polymerization in the presence of water by ultraviolet curing with initiator and multifunctional cross-linking agent, and include a buffer system to prevent discoloration, hydrolysis of and improve shelf-life of the hydrogels. Other additives may be added to the hydrogels either before or after curing, depending on the intended end use. The present hydrogels hydrate a subject's skin, wet around skin surface hair and protect against burning of a subject due to electrical stimulation through the hydrogel. The hydrogels, cohesiveness enables direct hydrogel-to-hydrogel contact and storage, yet remain readily separable. The hydrogels may be presented in a formula which is noncorrosive to aluminum in contact therewith, and pass standards testing for biocompatibility and electrical properties.

摘要翻译： 提供用作皮肤接触粘合剂的导电粘合剂水凝胶和用于一次性医疗装置的电接口的组合物。 水凝胶是阳离子丙烯酸酯，并且由四元氯化物和/或硫酸酯的丙烯酸酯或季氯化物的丙烯酰胺制成。 本发明的水凝胶通过在引发剂和多功能交联剂的紫外线固化下在水存在下通过自由基聚合形成，并且包括缓冲体系以防止水凝胶的变色，水解和提高保质期。 取决于预期的最终用途，可以在固化之前或之后将其他添加剂加入到水凝胶中。 本发明的水凝胶水合受试者的皮肤，润湿皮肤表面的毛发并防止由于通过水凝胶的电刺激而使受试者燃烧。 水凝胶，凝聚性使得直接的水凝胶与水凝胶的接触和储存成为可能，但仍然容易分离。 水凝胶可以以与其接触的铝无腐蚀性的配方呈现，并且通过用于生物相容性和电特性的标准测试。