公开(公告)号：EP3166933B1

公开(公告)日：2018-08-01

申请号：EP15821964.2

申请日：2015-07-14

申请人： Centrax International Inc.

发明人： YANG, Jinfu ,  CEN, Jian James ,  FAN, Xiaoqing Michelle

IPC分类号： C07D303/32 ,  C07D413/14 ,  C07D413/12 ,  A61K31/336 ,  A61K31/5377 ,  A61P35/00 ,  A61P25/28 ,  C07K5/083 ,  C07K5/087 ,  C07K5/065

CPC分类号： C07K5/06078 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0806 ,  C07K5/0821

摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein have improved proteasome potency and selectivity, and increased aqueous solubility, and are useful in treating various conditions or diseases associated with proteasomes.

公开(公告)号：EP3166933A2

公开(公告)日：2017-05-17

申请号：EP15821964.2

申请日：2015-07-14

申请人： Centrax International Inc.

发明人： YANG, Jinfu ,  CEN, Jian James ,  FAN, Xiaoqing Michelle

IPC分类号： C07D303/32 ,  C07D413/14 ,  C07D413/12 ,  A61K31/336 ,  A61K31/5377 ,  A61P35/00 ,  A61P25/28

CPC分类号： C07K5/06078 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0806 ,  C07K5/0821

摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein have improved proteasome potency and selectivity, and increased aqueous solubility, and are useful in treating various conditions or diseases associated with proteasomes.

摘要翻译： 本公开涉及可用作蛋白酶体抑制剂的新化合物及其药物组合物。 本文提供的化合物具有改善的蛋白酶体效能和选择性，并且增加水溶性，并且可用于治疗与蛋白酶体相关的各种病症或疾病。