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1.发明公开
公开(公告)号：EP4431617A1
公开(公告)日：2024-09-18
申请号：EP23162720.9
申请日：2023-03-17
申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , Charité - Universitätsmedizin Berlin
IPC分类号： C12Q1/6869 , C12Q1/6883
CPC分类号： C12Q1/6869 , C12Q1/6886 , C12Q2600/15620130101 , C12Q2600/11820130101
摘要： The present invention relates to a method for analyzing the DNA break repair machinery of a subject, in particular, for determining at least one deficiency in the DNA break repair machinery, and, on this basis, for predicting the DNA break repair efficiency of the subject. While the analysis is performed in B-cells and comprises analyzing switch-joints of the immunoglobulin heavy chain locus (!GH) of said B-cells, the results can generally be used to predict the risk to develop a cancer, an immunodeficiency such as common variable immunodeficiency (CVID) or a neurodevelopmental disease such as ataxia telangiectasia (AT), for determining the prognosis of a cancer, or for selecting a method of treating a cancer. The invention also relates to a computer program product comprising instructions which, when the program is executed by a computer, cause the computer to carry out specific steps of the analysis, and to a kit comprising said computer program product. The method of the invention is also designated Switch-joint Breakpoint Repertoire Identification (SWIBRID).
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公开(公告)号：EP4341963A1
公开(公告)日：2024-03-27
申请号：EP22729669.6
申请日：2022-05-19
发明人： BERNDT, Nikolaus , KÜHNE, Titus
IPC分类号： G16H50/30 , G16H50/50 , G01N33/68 , G01N33/574 , G16B5/00
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公开(公告)号：EP4308933A1
公开(公告)日：2024-01-24
申请号：EP22716910.9
申请日：2022-03-18
发明人： THIEL, Andreas , LOYAL, Lucie , HENZE, Larissa , BRAUN, Julian
IPC分类号： G01N33/569 , C07K14/005
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公开(公告)号：EP4301844A1
公开(公告)日：2024-01-10
申请号：EP22708383.9
申请日：2022-01-31
IPC分类号： C12N5/077 , C12N15/09 , C12N15/11 , C12N15/63 , C07K14/435 , C07K14/78 , C12N15/113
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公开(公告)号：EP4240479A1
公开(公告)日：2023-09-13
申请号：EP21811264.7
申请日：2021-11-08
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公开(公告)号：EP4226203A1
公开(公告)日：2023-08-16
申请号：EP21787449.4
申请日：2021-10-06
发明人： TEN, Foo, Wei , CONRAD, Christian , EILS, Roland , YANG, Li-Ling
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公开(公告)号：EP4220450A1
公开(公告)日：2023-08-02
申请号：EP22154418.2
申请日：2022-02-01
发明人： Tobias, Penzkofer , Jens, Kleesiek
摘要： The present invention concerns a computer-implemented method for the controlled provision of electronic data for machine learning, in particular machine-learning training data, between research and development entities is provided, wherein the method may comprise the following steps that may be performed by a data sharing platform computer system: receiving, from a data recipient computer system, user input comprising one or more selection criteria for an electronic data set, wherein the one or more selection criteria may include a selection of at least one data provider computer system; causing, using application programming interfaces (APIs) that may be provided to the data recipient and may be provided to the at least one data provider, the selected at least one data provider to provide the electronic data set to the data recipient, preferably over a secured connection between the data recipient and the at least one data provider; and enforcing, using at least part of the APIs of the data provider and/or data recipient, at least one usage constraint that may be defined by the at least one data provider on the electronic data set.
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公开(公告)号：EP4176898A1
公开(公告)日：2023-05-10
申请号：EP22170226.9
申请日：2022-04-27
摘要： In one aspect, the invention relates to a Sars-Cov-2 vaccine antigen amino acid sequence comprising a plurality of each of: nonstructural protein T cell epitopes, accessory protein T cell epitopes, spike protein T cell epitopes, envelope protein T cell epitopes, membrane protein T cell epitopes, nucleocapsid protein T cell epitopes.
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9.发明公开
公开(公告)号：EP4157360A1
公开(公告)日：2023-04-05
申请号：EP21728216.9
申请日：2021-05-25
发明人： HAMM, Bernd , SCHELLENBERGER, Eyk , SCHNORR, Jörg , HAUPTMANN, Ralf , HÄCKEL, Akvile , XIE, Jing
IPC分类号： A61K49/10 , C07C229/16 , C07C237/04
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10.发明公开
公开(公告)号：EP4154889A1
公开(公告)日：2023-03-29
申请号：EP22197344.9
申请日：2022-09-23
申请人： Charité - Universitätsmedizin Berlin , Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
IPC分类号： A61K31/4985 , A61K31/519 , A61K31/53 , A61K45/06 , A61P25/02 , A61P21/00 , A61P27/02 , A61P25/28 , A61P25/08
摘要： The invention relates to a PDE5 inhibitor for use in the treatment and/or prevention of a medical condition associated with mitochondrial Complex V (ATP synthase) deficiency in a human subject. In embodiments, the mitochondrial Complex V deficiency comprises at least one mutation within a structural subunit gene, or within an assembly gene, of the mitochondrial Complex V (ATP synthase). In embodiments, the invention relates to PDE5 inhibitors, such as sildenafil or tadalafil, in the treatment and/or prevention of a Maternally Inherited Leigh syndrome (MILS), a Neuropathy, an Ataxia or a Retinitis Pigmentosa (NARP) syndrome, or a neurological syndrome associated with a mitochondrial Complex V deficiency. In embodiments, the invention relates to treatment of mitochondrial Complex V deficiency caused by at least one mutation in nuclear or mitochondrial DNA, preferably DNA mutations in the MT-ATP6 gene causing MILS or NARP. The invention further relates to a pharmaceutical composition comprising a PDE5 inhibitor for use in the treatment and/or prevention of a medical condition associated with mitochondrial Complex V deficiency.
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