公开(公告)号：EP3976768A1

公开(公告)日：2022-04-06

申请号：EP19732485.8

申请日：2019-05-28

申请人： Chiang Mai University ,  National Science and Technology Development Agency (NSTDA)

发明人： SITTISOMBUT, Nopporn ,  SAE-LIM, Malinee ,  CHAROENSRI, Nicha ,  KEELAPANG, Poonsook

IPC分类号： C12N7/00 ,  C12N15/40 ,  C07K14/18 ,  A61K39/12

公开(公告)号：EP1778727A1

公开(公告)日：2007-05-02

申请号：EP05748554.2

申请日：2005-06-01

申请人： The National Research Council of Thailand ,  The Thailand Research Fund ,  Chiang Mai University

发明人： KONGTAWELERT, Prachya, Department of Biochemistry ,  HARDINGHAM, Tim, School of Biological Sciences ,  ONG-CHAI, Siriwan, Department of Biochemistry ,  SUGAHARA, Kazuyuki, Department of Biochemistry ,  POTHACHAROEN, Peraphan, Department of Biochemistry ,  TIENGBURANATHUM, Natthachai, Dpt. of Biochemistry

IPC分类号： C07K16/18 ,  C07K16/30 ,  C12N5/20 ,  G01N33/53 ,  A61K39/395 ,  A61P19/02 ,  A61P19/04

CPC分类号： C07K16/18 ,  G01N33/57407 ,  G01N33/6887 ,  G01N2400/40 ,  G01N2800/10 ,  G01N2800/102

摘要： An antibody specific for a chondroitin sulphate epitope is described, as is a hybridoma cell line which produces such an antibody. The antibody is useful in the diagnosis and treatment of connective tissue diseases, such as arthritis and sarcomas. Test kits and pharmaceutical compositions are also described.

公开(公告)号：EP1778727B1

公开(公告)日：2014-08-06

申请号：EP05748554.2

申请日：2005-06-01

申请人： The National Research Council of Thailand ,  The Thailand Research Fund ,  Chiang Mai University

发明人： KONGTAWELERT, Prachya ,  HARDINGHAM, Tim ,  ONG-CHAI, Siriwan ,  SUGAHARA, Kazuyuki ,  POTHACHAROEN, Peraphan ,  TIENGBURANATHUM, Natthachai

IPC分类号： C07K16/18 ,  C07K16/30 ,  C12N5/20 ,  G01N33/53 ,  A61K39/395 ,  A61P19/02 ,  A61P19/04

CPC分类号： C07K16/18 ,  G01N33/57407 ,  G01N33/6887 ,  G01N2400/40 ,  G01N2800/10 ,  G01N2800/102

公开(公告)号：EP2920188A1

公开(公告)日：2015-09-23

申请号：EP13802133.2

申请日：2013-10-30

申请人： Chiang Mai University

发明人： MEEPOWPAN, Puttinan ,  PUNYODOM, Winita ,  MOLLOY, Robert

IPC分类号： C07F7/22

CPC分类号： C07F7/2232 ,  C07F7/2296

摘要： This invention describes the synthetic process of producing liquid tin(II) alkoxides for use as either reagents in the synthesis of lactide or as initiators in the polymerization of cyclic ester monomers to yield biodegradable polyesters. The synthetic process employs anhydrous tin(II) chloride dissolved in n-heptane and mixed with dry diethylamine. Alcohols, ROH, in which the R groups are
n -C
4 H
9 ,
n -C
6 H
13 , and
n -C
8 H
17 are added to the reaction mixture and stirred for 12 hours. The reaction mixture isthen filtered under nitrogen or argon before being evaporated to dryness to yield the three tin(II) alkoxides, namely: tin(II)
n -butoxide, tin(II)
n - hexoxide, and tin(II)
n -octoxide. All three tin(II) alkoxides are viscous, dark yellow liquids which are highly soluble in most common organic solvents. Furthermore,they can all be stored under an inert atmosphere for long periods without any significant change in their vi nd therefore in their effectiveness as rea ents/initiators.