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    PROCESS FOR THE PREPARATION OF CARVEDILOL
    3.
    发明授权
    PROCESS FOR THE PREPARATION OF CARVEDILOL 有权
    用于生产卡维地洛

    公开(公告)号：EP1756057B1

    公开(公告)日：2010-08-04

    申请号：EP05744187.5

    申请日：2005-05-19

    申请人： Cipla Ltd.

    发明人： KANKAN, Rajendra Narayanrao ,  RAO, Dharmaraj Ramachandra, 4/403 Garden Enclave

    IPC分类号： C07D209/88

    CPC分类号： C07D209/88

    摘要： A process for the preparation of carvedilol of formula (I) (I) either in enantiomeric substantially pure form, or as an enantiomeric mixture, optionally as a pharmaceutically acceptable salt thereof, which process comprises reacting 2,3-eopxypropoxy carbazole of formula (II) (II) or the R or S enantiomer thereof, with N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) (V) to yield benzyl carvedilol of formula (VI) (VI) which is debenzylated by catalytic hydrogenation to yield carvedilol of formula (I), either in enantiomeric substantially pure form, or as an enantiomeric mixture, and if desired reacting the thus formed carvedilol of formula (I) with an inorganic or organic acid to yield a pharmaceutically acceptable salt thereof, and/or, if desired, separating the enantiomers. The above process is characterised in that reaction of said 2,3-epoxypropoxy carbazole of formula (II) with said N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) is carried out in water as the reaction medium. The present invention further provides carvedilol of formula (I) prepared by a process as described above, and pharmaceutical compositions containing the same and therapeutic uses thereof.

    INHALER DEVICE
    5.
    发明公开
    INHALER DEVICE 审中-公开
    气雾

    公开(公告)号：EP1901793A1

    公开(公告)日：2008-03-26

    申请号：EP06764950.9

    申请日：2006-07-13

    申请人： Cipla Ltd.

    发明人： LULLA, Amar 131 Maker Towers "L", 13th Floor ,  MALHOTRA, Geena 4 Anderson House

    IPC分类号： A61M15/00 ,  A61M11/06

    CPC分类号： A61M15/0028 ,  A61M11/002 ,  A61M15/002 ,  A61M15/0036 ,  A61M2202/064 ,  A61M2205/6045 ,  A61M2206/16

    摘要： An inhaler device (2) is for the inhalation of particulate substances is provided. The device comprises a housing (5) having first and second openings, a first air passageway (11) being defined through said housing between said first and second openings, an extraction member (40) extending from said housing and having a second air passageway (46) formed therein, and an airflow directing means (16) proximate one of said first and second openings.

    摘要翻译： 吸入器装置（2）用于吸入颗粒物质。 该装置包括具有第一和第二开口的壳体（5），在所述第一和第二开口之间限定穿过所述壳体的第一空气通道（11），从所述壳体延伸并具有第二空气通道 46），以及靠近所述第一和第二开口之一的气流引导装置（16）。

    Preparation of valganciclovir
    6.
    发明公开
    Preparation of valganciclovir 审中-公开
    Herstellung von Valganciclovir

    公开(公告)号：EP1837336A1

    公开(公告)日：2007-09-26

    申请号：EP07251200.7

    申请日：2007-03-21

    申请人： Cipla Ltd.

    发明人： Ramchandra, Rao Dharamaraj ,  Narayanrao, Kankan Rajendra ,  Purushottam, Pande Vidyadhar

    IPC分类号： C07D473/18

    CPC分类号： C07D473/18

    摘要： A process for the preparation of valganciclovir with triacetyl ganciclovir (V) as a starting material, comprising the following steps: selective hydrolysis, reacting with a coupling agent and a solvent, followed by hydrolysis under basic conditions and hydrogenolysis in the presence of a catalyst.

    摘要翻译： 用三乙酰基更昔洛韦（V）作为原料制备缬更昔洛韦的方法，包括以下步骤：选择性水解，与偶联剂和溶剂反应，然后在碱性条件下水解，并在催化剂存在下氢解。

    TRANSDERMAL PHARMACEUTICAL SPRAY FORMULATIONS COMPRISING A VP/VA COPOLYMER AND A NON-AQUEOUS VEHICLE
    8.
    发明公开
    TRANSDERMAL PHARMACEUTICAL SPRAY FORMULATIONS COMPRISING A VP/VA COPOLYMER AND A NON-AQUEOUS VEHICLE 审中-公开
    WITH A VP / VA共聚物和的非水性载体皮药物喷雾制剂

    公开(公告)号：EP1686969A1

    公开(公告)日：2006-08-09

    申请号：EP04769002.9

    申请日：2004-10-21

    申请人： Cipla Ltd.

    发明人： LULLA, Amar ,  MALHOTRA, Geena

    IPC分类号： A61K9/70 ,  A61K31/568

    CPC分类号： A61K31/568 ,  A61K9/12 ,  A61K9/7015

    摘要： Transdermal spray formulations containing a pharmaceutically active agent and methods for administering the same are provided. The formulations comprise the pharmaceutically active agent, a VP/VA copolymer and a non-aqueous vehicle. The formulations further comprise an anti-nucleating agent to prevent recrystallization of the pharmaceutically active agent and a penetration enhancer to increase the rate of drug delivery through the skin. Upon application to the skin, the present formulations dry to provide a film at the site of treatment.

    FEXOFENADINE POLYMORPHS AND PROCESSES OF PREPARING THE SAME
    9.
    发明公开
    FEXOFENADINE POLYMORPHS AND PROCESSES OF PREPARING THE SAME 有权
    FEXOFENADINE POLYMORPHS及其制备方法

    公开(公告)号：EP1667971A1

    公开(公告)日：2006-06-14

    申请号：EP04768180.4

    申请日：2004-08-25

    申请人： Cipla Ltd.

    发明人： RAO, Dharmaraj Ramachandra ,  KANKAN, Rajendra Narayanrao ,  GANGRADE, Manish Gopaldas ,  BIRARI, Dilip Ramdas

    IPC分类号： C07D211/22 ,  A61K31/445 ,  A61P37/00

    CPC分类号： C07D211/22

    摘要： Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith.

    摘要翻译： 无水结晶非索非那定盐酸盐形式C，结晶非索非那丁乙酸盐一水合物形式D，结晶非索非那丁乙酸盐二水合物形式E和结晶非索非那定游离碱一水合物形式F，其制备方法，其药物组合物，其治疗用途及其治疗方法。