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公开(公告)号：EP4155312A1
公开(公告)日：2023-03-29
申请号：EP21809650.1
申请日：2021-05-18
发明人： CHEN, Shuhui , FENG, Jiajie , WEI, Wei , LI, Peng , HE, Haiying , LIU, Jinxin , LI, Jian
IPC分类号： C07D498/14 , C07D471/14
摘要： Disclosed are a kind of fused ring derivatives, and specifically disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.
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公开(公告)号：EP2786998B1
公开(公告)日：2018-07-25
申请号：EP12853993.9
申请日：2012-10-23
申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Cisen Pharmaceutical Co., Ltd.
发明人： LIU, Hong , LI, Jia , LI, Jian , LI, Jingya , WANG, Jiang , SU, Mingbo , LIAN, Jie , JIANG, Hualiang , CHEN, Kaixian
IPC分类号： C07D495/04 , A61K31/519 , A61K31/55 , A61P3/10
CPC分类号： C07D495/04
摘要： Disclosed are new thienyl [3, 2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.
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公开(公告)号：EP4046999A1
公开(公告)日：2022-08-24
申请号：EP20877068.5
申请日：2020-10-16
发明人： ZHOU, Ming , XU, Zhaobing , LI, Gang , HU, Lihong , DING, Charles Z. , JIANG, Wen , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
摘要： Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.
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公开(公告)号：EP3159342A4
公开(公告)日：2018-05-16
申请号：EP15810204
申请日：2015-06-16
发明人： GUAN HUIPING , WU CHENGDE , YU TAO , HUANG LEI , HAO DONGLING , GAO BO , SUN JIKUI , SHI NENGYANG , CHEN SHUHUI
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00 , C07D487/04 , C07D491/147
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D491/147
摘要： Disclosed is a pyridino[1, 2-a]pyrimidone analogue used as an mTOR/PI3K inhibitor. The present invention particularly relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
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5.发明公开2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 有权2-芳基苯并呋喃-7-甲酰胺，其制造方法及其用途
公开(公告)号：EP2813495A4
公开(公告)日：2015-06-17
申请号：EP13746724
申请日：2013-01-14
发明人： YANG CHUNHAO , MIAO ZEHONG , DING JIAN , WANG MENG , HE JINXUE , TAN CUN , CHEN YI
IPC分类号： C07D307/81 , A61P29/00 , A61P35/00 , C07D405/04 , C07D405/12
CPC分类号： C07D307/81 , C07C67/08 , C07C67/307 , C07D405/04 , C07D405/12 , C07D407/12
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公开(公告)号：EP3170810A4
公开(公告)日：2017-12-06
申请号：EP15821285
申请日：2015-07-09
发明人： DING ZHAOZHONG , CHEN SHUHUI , HUANG ZHIGANG , LUO WEI , CAI ZHE , WANG YEPENG , TANG DONGDONG
IPC分类号： C07D213/64 , A61P31/04 , A61P31/06 , C07D213/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D417/04
CPC分类号： C07D213/643 , A61K31/44 , C07D213/57 , C07D213/64 , C07D213/647 , C07D213/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.
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公开(公告)号：EP3170810A1
公开(公告)日：2017-05-24
申请号：EP15821285.2
申请日：2015-07-09
发明人： DING, Zhaozhong , CHEN, Shuhui , HUANG, Zhigang , LUO, Wei , CAI, Zhe , WANG, Yepeng , TANG, Dongdong
IPC分类号： C07D213/64 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D213/74 , C07D401/06 , A61P31/06 , A61P31/04
CPC分类号： C07D213/643 , A61K31/44 , C07D213/57 , C07D213/64 , C07D213/647 , C07D213/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.
摘要翻译： 公开了一系列新的吡啶衍生物的制备方法及其用途。 这些衍生物可用于治疗由分枝杆菌引起的相关疾病，特别是由致病性分枝杆菌引起的疾病，如结核分枝杆菌，牛分枝杆菌，鸟分枝杆菌和海分枝杆菌。
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8.发明公开PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS MTOR/PI3K INHIBITOR 审中-公开用作MTOR / PI3K抑制剂的吡啶并[1,2-a]嘧啶类似物
公开(公告)号：EP3159342A1
公开(公告)日：2017-04-26
申请号：EP15810204.6
申请日：2015-06-16
发明人： GUAN, Huiping , WU, Chengde , YU, Tao , HUANG, Lei , HAO, Dongling , GAO, Bo , SUN, Jikui , SHI, Nengyang , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
摘要： Disclosed is a pyridino[1, 2-a]pyrimidone analogue used as an mTOR/PI3K inhibitor. The present invention particularly relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了用作mTOR / PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物。 本发明特别涉及由式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：EP3159342B1
公开(公告)日：2020-08-05
申请号：EP15810204.6
申请日：2015-06-16
发明人： GUAN, Huiping , WU, Chengde , YU, Tao , HUANG, Lei , HAO, Dongling , GAO, Bo , SUN, Jikui , SHI, Nengyang , CHEN, Shuhui
IPC分类号： C07D471/04 , C07D487/04 , C07D491/147 , A61K31/519 , A61P35/00
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公开(公告)号：EP3170810B1
公开(公告)日：2018-09-19
申请号：EP15821285.2
申请日：2015-07-09
发明人： DING, Zhaozhong , CHEN, Shuhui , HUANG, Zhigang , LUO, Wei , CAI, Zhe , WANG, Yepeng , TANG, Dongdong
IPC分类号： C07D213/64 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D213/74 , C07D401/06 , A61P31/06 , A61P31/04
CPC分类号： C07D213/643 , A61K31/44 , C07D213/57 , C07D213/64 , C07D213/647 , C07D213/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.
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