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1.发明授权PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 有权用于生产17烯丙基氨基格尔德霉素（17-AAG）以及其他安莎霉素
公开(公告)号：EP1435939B1
公开(公告)日：2008-02-27
申请号：EP02761732.3
申请日：2002-09-18
发明人： ZHANG, Lin , BOEHM, Marcus F. , ZEGAR, Siead
IPC分类号： A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
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2.发明公开ASSAYS AND IMPLEMENTS FOR DETERMINING AND MODULATING HSP90 BINDING ACTIVITY 审中-公开测定以及一种用于确定和HSP90结合活性的调节
公开(公告)号：EP1519735A2
公开(公告)日：2005-04-06
申请号：EP02799944.0
申请日：2002-12-12
CPC分类号： G01N33/5008 , A61K31/00 , A61K31/4188 , A61K45/06 , A61K47/557 , A61K49/0004 , C07D225/06 , C07D495/04 , C07K14/47 , G01N33/5011 , G01N33/5044 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6842 , G01N2333/4703 , G01N2500/04
摘要： Ligand binding assays as applied to HSP90s as receptors or ligands, and reagents useful therefore, are described and claimed, as are methods of assaying for HSP90 modulators and methods of using the resulting products identified thereby.
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3.发明公开PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 有权制备17-烯丙基氨基米氮霉素（17-AAG）和其他类固醇的方法
公开(公告)号：EP1435939A2
公开(公告)日：2004-07-14
申请号：EP02761732.3
申请日：2002-09-18
发明人： ZHANG, Lin , BOEHM, Marcus F. , ZEGAR, Siead
IPC分类号： A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
摘要： Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
摘要翻译： 描述并要求保护用于制备17-烯丙基氨基格尔德霉素（17-AAG）和其他安沙霉素的高产率，纯度和不同多晶型形式的有效化学方法。
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4.发明公开METHODS FOR TREATING GENETICALLY-DEFINED PROLIFERATIVE DISORDERS WITH HSP90 INHIBITORS 审中-公开方法与HSP90遗传确定的增生性疾病的治疗抑制剂
公开(公告)号：EP1423080A2
公开(公告)日：2004-06-02
申请号：EP02721238.0
申请日：2002-03-01
IPC分类号： A61K6/00
CPC分类号： A61K31/33 , A61K31/395 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： The invention relates generally to methods of treating cell proliferative diseases with HSP90 inhibitors and, depending on the specific aspect and embodiment(s) claimed, to the treatment of proliferative diseases that are associated with fusion proteins, e.g., bcrabl, or mutant proteins or cellular protein isoforms, e.g., mutant forms of p53.
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公开(公告)号：EP1440072A2
公开(公告)日：2004-07-28
申请号：EP02780559.7
申请日：2002-10-30
发明人： KASIBHATLA, Srinivas Rao , HONG, Kevin , ZHANG, Lin , BIAMONTE, Marco Antonio , BOEHM, Marcus F. , SHI, Jiandong , FAN, Junhua
IPC分类号： C07D473/40
CPC分类号： C07D473/00 , C07D473/16 , C07D473/24 , C07D473/34 , C07D473/40
摘要： Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.
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公开(公告)号：EP1670802A2
公开(公告)日：2006-06-21
申请号：EP04788954.8
申请日：2004-09-20
发明人： KASIBHATLA, Srinivas R. , BOEHM, Marcus F. , HONG, Kevin D. , BIAMONTE, Marco A. , SHI, Jiandong , LE BRAZIDEC, Jean-Yves , ZHANG, Lin , HURST, David
IPC分类号： C07D487/04 , C07D471/04 , C07D473/32 , C07D473/40 , C07D473/18 , C07D473/24 , A61K31/519 , A61K31/522 , A61K31/52 , A61P35/00 , A61P37/06
CPC分类号： C07D487/04 , C07D471/04 , C07D473/00
摘要： Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.
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公开(公告)号：EP1472230A2
公开(公告)日：2004-11-03
申请号：EP03713437.6
申请日：2003-02-10
发明人： ZHANG, Lin , LE BRAZIDEC, Jean-Yves , BOEHM, Marcus, F. , MCHUGH, Sean, Konrad , FAN, Junhua , FRITZ, Lawrence, C. , BURROWS, Francis, J.
IPC分类号： C07D233/14 , A61K31/33
CPC分类号： C07D225/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07F9/5535
摘要： Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
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