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1.发明授权PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 有权用于生产17烯丙基氨基格尔德霉素（17-AAG）以及其他安莎霉素
公开(公告)号：EP1435939B1
公开(公告)日：2008-02-27
申请号：EP02761732.3
申请日：2002-09-18
发明人： ZHANG, Lin , BOEHM, Marcus F. , ZEGAR, Siead
IPC分类号： A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
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2.发明公开PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 有权用于生产17烯丙基氨基格尔德霉素（17-AAG）以及其他安莎霉素
公开(公告)号：EP1435939A4
公开(公告)日：2004-12-29
申请号：EP02761732
申请日：2002-09-18
发明人： ZHANG LIN , BOEHM MARCUS F , ZEGAR SIEAD
IPC分类号： C07D225/06 , A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
摘要： Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
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3.发明公开4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS 失效ANALOGE DES 4-SUBSTITUIERTEN PIPERIDINS DEREM VERWENDUNG ALS SELEKTIVE ANTAGONISTEN DES NMDA-SUBTYPREZEPTONS
公开(公告)号：EP0869792A4
公开(公告)日：1999-09-22
申请号：EP96945682
申请日：1996-12-20
申请人： WARNER LAMBERT CO , COCENSYS INC , BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKHARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG LIN , YEUN WAI
发明人： BIGGE CHRISTOPHER F , CAI SUI XIONG , WEBER ECKARD , WOODWARD RICHARD , KEANA JOHN F W , LAN NANCY C , GUZIKOWSKI ANTHONY P , ZHOU ZHANG-LIN , YEUN PO-WAI
IPC分类号： C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04 , A61K31/445
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
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公开(公告)号：EP3920895A1
公开(公告)日：2021-12-15
申请号：EP20752141.0
申请日：2020-02-03
申请人： Yu, Jian , Zhang, Lin , Leibowitz, Brian
发明人： Yu, Jian , Zhang, Lin , Leibowitz, Brian
IPC分类号： A61K31/045 , A61K31/496 , A61P1/00 , A61P39/02
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5.发明授权4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS 失效模拟4-取代NMDA SUBTYPREZEPTONS的哌啶和DEREM使用AS选择性拮抗剂
公开(公告)号：EP0869792B1
公开(公告)日：2005-03-09
申请号：EP96945682.1
申请日：1996-12-20
申请人： Warner-Lambert Company LLC , Cocensys, Inc. , Bigge, Christopher F. , Cai, Sui Xiong , Weber, Eckhard , Woodward, Richard , KEANA, John F.W. , Lan, Nancy C. , Guzikowski, Anthony P. , Zhou, Zhang-Lin , Yeun, Po-Wai
发明人： BIGGE, Christopher, F. , CAI, Sui, Xiong , WEBER, Eckard , WOODWARD, Richard , KEANA, John, F., W. , LAN, Nancy, C. , GUZIKOWSKI, Anthony, P. , ZHOU, Zhang-Lin , YEUN, Po-Wai
IPC分类号： A61K31/445 , C07D211/14 , C07D401/12 , C07D211/48 , C07D211/18
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
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6.发明公开PROCESS FOR PREPARING 17-ALLYL AMINO GELDANAMYCIN (17-AAG) AND OTHER ANSAMYCINS 有权制备17-烯丙基氨基米氮霉素（17-AAG）和其他类固醇的方法
公开(公告)号：EP1435939A2
公开(公告)日：2004-07-14
申请号：EP02761732.3
申请日：2002-09-18
发明人： ZHANG, Lin , BOEHM, Marcus F. , ZEGAR, Siead
IPC分类号： A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
摘要： Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
摘要翻译： 描述并要求保护用于制备17-烯丙基氨基格尔德霉素（17-AAG）和其他安沙霉素的高产率，纯度和不同多晶型形式的有效化学方法。
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7.发明公开4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS 失效模拟4-取代NMDA SUBTYPREZEPTONS的哌啶和DEREM使用AS选择性拮抗剂
公开(公告)号：EP0869792A2
公开(公告)日：1998-10-14
申请号：EP96945682.0
申请日：1996-12-20
申请人： WARNER-LAMBERT COMPANY , Cocensys, Inc. , Bigge, Christopher F. , Cai, Sui Xiong , Weber, Eckhard , Woodward, Richard , KEANA, John F.W. , Lan, Nancy C. , Guzikowski, Anthony P. , Zhou, Zhang-Lin , Yeun, Po-Wai
发明人： BIGGE, Christopher, F. , CAI, Sui, Xiong , WEBER, Eckard , WOODWARD, Richard , KEANA, John, F., W. , LAN, Nancy, C. , GUZIKOWSKI, Anthony, P. , ZHOU, Zhang-Lin , YEUN, Po-Wai
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/28 , C07D211/30 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/64 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
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8.发明公开Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins 审中-公开Verfahren zur Herstellung eines 17-Allyl-amino-Geldanamycins（17-AAG）und anderer Ansamycine
公开(公告)号：EP1923061A1
公开(公告)日：2008-05-21
申请号：EP08101997.8
申请日：2002-09-18
发明人： Zhang, Lin , Boehm, Marcus F. , Zegar, Siead
IPC分类号： A61K31/33 , A61K31/55 , C07D225/04
CPC分类号： C07D225/06
摘要： Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
摘要翻译： 描述和要求保护高产量，纯度和不同形式的17-烯丙基氨基格尔德霉素（17-AAG）和其他安莎霉素的高效化学方法。
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