公开(公告)号：EP4458422A1

公开(公告)日：2024-11-06

申请号：EP22916104.7

申请日：2022-12-27

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  TANAKA, Hiroshi ,  MURAYAMA, Tomohiro ,  KAMIYAMA, Fumio

IPC: A61Q19/00 ,  A61K8/04 ,  A61K8/34 ,  A61K8/44 ,  A61K8/64 ,  A61K8/67

Abstract: Provided are a means for crystallizing a valuable substance that is unstable in an aqueous solution state and stably dispersing the substance in an oily medium, an aqueous medium, or an emulsified medium in which the oily medium and the aqueous medium are mixed, and to a composition for application to skin with which a crystallized valuable substance is absorbed through the skin. A skin care composition for application to skin, including a valuable substance that is dispersed in a crystalline state, and a method for producing a skin care composition for application to skin, the method including a step of preparing a solution of a valuable substance at a supersaturation concentration, adding the solution to a composition for application to skin, and precipitating crystals while stirring under cooling.

公开(公告)号：EP4159266A1

公开(公告)日：2023-04-05

申请号：EP21812732.2

申请日：2021-05-24

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  LI, Ying-zhe ,  KAJIYAMA, Kenji ,  SAITO, Mio ,  YAMASHITA, Hirofumi ,  KAMIYAMA, Fumio

IPC: A61M37/00

Abstract: Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 um or more and 2000 um or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.

公开(公告)号：EP4159240A1

公开(公告)日：2023-04-05

申请号：EP21818496.8

申请日：2021-05-28

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  KONDOU, Naoko ,  TANAKA, Hiroshi ,  KAMIYAMA, Fumio

IPC: A61K45/00 ,  A61P3/04 ,  A61K9/00 ,  A61K36/00 ,  A61K47/36 ,  A61K38/46 ,  A61M37/00 ,  A61K31/047 ,  A61K31/165 ,  A61K31/198 ,  A61K31/205 ,  A61K31/522 ,  A61K31/575 ,  A61K31/685 ,  A61K31/7076

Abstract: Provided is a new means for administering a valuable substance having a fat dissolving action. A microneedle preparation including at least one of a lipolytic agent, a fat dissolving agent, or a fat metabolism promoting agent, the microneedle preparation being intended for fat reduction and/or partial slenderizing and/or skin tightening, and a microneedle preparation including a microneedle array containing a water-soluble polymer as a base and one or more selected from the group consisting of a lipase, a phosphatidylcholine, and deoxycholic acid.

公开(公告)号：EP3047871B1

公开(公告)日：2018-05-02

申请号：EP13894024.2

申请日：2013-09-18

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  KAMIYAMA, Fumio

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2205/8281

Abstract: Provided is a device for surely and easily applying a microneedle patch to a skin. In a case body 2, a pressing member 3 having a tip surface 3a is disposed such that the pressing member is biased in a first direction X1 by a first biasing member. The movement in the first direction X1 is locked by a locking member 7 and a locking part 3g so that the pressing member 3 is brought into a locked state. The locked state is released by pressing a tip of a lock-releasing member 11 against the skin. When the locked state is released, a tip surface 3a of the pressing member 3 is moved in the first direction X1 and the tip surface 3a applies the microneedle patch to the skin.

公开(公告)号：EP3108870A4

公开(公告)日：2017-08-16

申请号：EP15749387

申请日：2015-02-12

Applicant: COSMED PHARMACEUTICAL CO LTD

Inventor： KONDOU NAOKO ,  QUAN YING-SHU ,  KAMIYAMA FUMIO

IPC: A61K8/20 ,  A61K8/02 ,  A61K8/04 ,  A61K8/34 ,  A61K8/365 ,  A61K8/73 ,  A61K8/81 ,  A61K8/85 ,  A61Q19/00

CPC classification number: A61K8/042 ,  A61K8/0216 ,  A61K8/345 ,  A61K8/365 ,  A61K8/73 ,  A61K8/731 ,  A61K8/733 ,  A61K8/735 ,  A61K8/8147 ,  A61K8/85 ,  A61K2800/10 ,  A61K2800/242 ,  A61Q19/00

公开(公告)号：EP2868341A4

公开(公告)日：2016-03-30

申请号：EP13810059

申请日：2013-06-25

Applicant: COSMED PHARMACEUTICAL CO LTD

Inventor： QUAN YING-SHU ,  KAMIYAMA FUMIO

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61F13/0008 ,  A61F2013/008 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2209/00 ,  F04C2270/0421

Abstract: Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.

公开(公告)号：EP1607104A4

公开(公告)日：2010-09-01

申请号：EP04723819

申请日：2004-03-26

Applicant: COSMED PHARMACEUTICAL CO LTD

Inventor： KOHARA MINORU

IPC: A61K9/70 ,  A61L15/44 ,  A61L15/58 ,  A61L24/00 ,  A61L24/06 ,  A61K47/32 ,  A61K47/14

CPC classification number: A61K9/7061 ,  A61L15/44 ,  A61L15/58 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/41 ,  A61L2300/602 ,  C08L33/04

公开(公告)号：EP2116256A1

公开(公告)日：2009-11-11

申请号：EP08712105.9

申请日：2008-02-28

Applicant: Cosmed Pharmaceutical Co., Ltd. ,  Osaka University

Inventor： NAKAGAWA, Shinsaku ,  OKADA, Naoki ,  FUJITA, Takuya ,  KAMIYAMA, Fumio ,  QUAN, Ying-shu

IPC: A61K39/02 ,  A61K9/70 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/002 ,  A61K39/12 ,  A61K39/35 ,  A61K39/39 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61P37/04 ,  A61P43/00

CPC classification number: A61K31/7088 ,  A61K9/7053 ,  A61K9/7061 ,  A61K39/00 ,  A61K39/12 ,  A61K39/235 ,  A61K39/292 ,  A61K39/35 ,  A61K48/0041 ,  A61K48/005 ,  A61K48/0075 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/555 ,  C12N2710/10034 ,  C12N2730/10134

Abstract: This invention is concernced with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation.
The transdermal immune preparations can regulate the immune response by applying the preparation to an intact skin, and which comprises a base material and an antigen or artificial synthetic nucleic acid laminated on the surface of the base material; the methods for producing transdermal immune preparations which comprises putting drops of an aqueous solution or suspension prepared by dissolving or suspending an antigen in water or a water-containing alcohol on the surface of a base material in order for the water or the water-containing alcohol to be absorbed in the base material, thereby forming an layer containing the antigen in a concentrated state on the surface of the base material; and the transdermal immunization methods which is haracterized by applying the transdermal immune preparation to an intact skin to regulate the immune response.

Abstract translation: 本发明涉及可以在不含任何佐剂的情况下表现出高免疫学活性的透皮免疫制剂，制备该制剂的方法和使用该制剂的透皮免疫方法。 透皮免疫制剂可以通过将制剂应用于完整皮肤来调节免疫应答，并且其包含层压在基材表面上的基材和抗原或人造合成核酸; 用于生产透皮免疫制剂的方法，其包括将通过将抗原溶解或悬浮在水或含水醇中而制备的水溶液或悬浮液滴在基材表面上以使水或含水醇 被吸收在基材中，从而在基材的表面上形成浓缩状态的含有抗原的层; 以及通过将透皮免疫制剂应用于完整皮肤以调节免疫应答而被表达的透皮免疫方法。

公开(公告)号：EP4509175A1

公开(公告)日：2025-02-19

申请号：EP23788412.7

申请日：2023-04-14

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： MURAYAMA, Tomohiro ,  TANAKA, Hiroshi ,  HASEGAWA, Junya ,  QUAN, Ying-shu ,  KAMIYAMA, Fumio

IPC: A61P17/16 ,  A61Q19/00 ,  A61K9/06 ,  A61K9/10 ,  A61K8/06 ,  A61K8/46 ,  A61K31/185

Abstract: Provided is a skin external agent composition containing taurine as crystals, which has smooth feel without any skin contact. A skin external agent composition containing fine needle-like or columnar crystals of taurine having a thickness of less than 150 micrometers and a length of less than 3000 micrometers, a method for producing fine needle-like or columnar crystals of taurine, the method including a step of growing crystals in an environment in which an aqueous solution in which taurine is dissolved is mixed with or brought into contact with a liquid substance having low solubility of taurine, and a method for producing a skin external agent composition, the method including the step of growing crystals and a step of blending the fine needle-like or columnar crystals of taurine obtained in the step of growing crystals into the skin external agent composition.

公开(公告)号：EP3960228A1

公开(公告)日：2022-03-02

申请号：EP20795886.9

申请日：2020-04-24

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  TANAKA, Hiroshi ,  KAMIYAMA, Fumio

IPC: A61M35/00 ,  A61M37/00

Abstract: Provided is a further stable method of moisture supply from an applicator having a nozzle attached thereto and configured to supply moisture from the back surface of a water-soluble sheet-like formulation. A nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface being smooth excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; a nozzle for hold and dissolution of a water-soluble sheet-like formulation, the nozzle including a nozzle having an end portion having a flat surface having a size such that a water-soluble sheet-like formulation can be held, the end portion having at least one hole, the flat surface having an uneven portion excluding the at least one hole, and ring-like foam disposed around a periphery of the end portion of the nozzle; and an applicator of a water-soluble sheet-like formulation, the applicator including a liquid container and the nozzle for hold and dissolution of a water-soluble sheet-like formulation.