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公开(公告)号:EP1812826A2
公开(公告)日:2007-08-01
申请号:EP05819548.8
申请日:2005-10-31
申请人: Donahue, Kevin
发明人: Donahue, Kevin
CPC分类号: B43L1/123 , A63H33/38 , B43L1/006 , G02B6/005 , G02B6/006 , G02B6/0063 , G03G7/0013 , G03G7/002 , G03G7/0026 , Y10T428/24802 , Y10T428/24826
摘要: A pressure-sensitive light extracting drawing surface including a light guide operable to receive a light source, wherein light is extracted from a light guide when pressure is applied to the drawing surface by a marking instrument. A resultant light-emitting drawing can be erased or can be made permanent. An optional multi-layered film disposed on the light guide allows drawings to be created in fluorescent, luminescent, phosphorescent, or photochromic colors. A background sheet containing designs may be inserted behind the light guide. The drawing surface can be embodied as a pressure-sensitive light extracting 'paper.' The invention may be embodied as a drawing tablet, a drawing tablet add-on to a modular graphic display device, or a toy drawing tablet for tracing alphabets, numerals, and characters from comic books, cartoons, and movies.
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公开(公告)号:EP1331950A1
公开(公告)日:2003-08-06
申请号:EP01983146.0
申请日:2001-10-15
申请人: The Johns Hopkins University , Donahue, Kevin J. , Marban, Eduardo , Nagata, Koichi , Lawrence, John H., III
CPC分类号: A61K48/0016
摘要: The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
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公开(公告)号:EP1812826A4
公开(公告)日:2010-03-31
申请号:EP05819548
申请日:2005-10-31
申请人: DONAHUE KEVIN
发明人: DONAHUE KEVIN
CPC分类号: B43L1/123 , A63H33/38 , B43L1/006 , G02B6/005 , G02B6/006 , G02B6/0063 , G03G7/0013 , G03G7/002 , G03G7/0026 , Y10T428/24802 , Y10T428/24826
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公开(公告)号:EP1331950B1
公开(公告)日:2009-10-14
申请号:EP01983146.0
申请日:2001-10-15
申请人: THE JOHNS HOPKINS UNIVERSITY , Donahue, Kevin J. , Marban, Eduardo , Nagata, Koichi , Lawrence, John H., III
CPC分类号: A61K48/0016
摘要: The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
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