摘要:
A computer system for analyzing a specimen processing workflow in a pathology laboratory including a display (103) and a processor (104) configured to provide a first interface (900), a second interface (1100), and a third interface (1200) to the display (103), receive, via the first interface (900), a first set of parameters associated with an existing specimen processing workflow in a pathology laboratory, the first set of parameters including a workflow process and a workflow scale, and determine, based on the first set of parameters, current performance data of the existing specimen processing workflow having an associated current cost information and current time utilization. The processor (104) may further be configured to receive, via the second interface (1100), a second set of parameters associated with a proposed modification to the existing specimen processing workflow, the second set of parameters including parameters associated with at least one laboratory device, determine, based on the first and second sets of parameters, revised performance data having an associated revised cost information and revised time utilization, and provide an output comprising a comparison between revised performance data and the current performance data.
摘要:
An apparatus (100) for processing a biological sample (101). The biological sample being arranged on a first planar surface (102) of a carrier (103), The apparatus comprises a second planar surface (104) arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said first planar surface and said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP); supply means (126, 131, 220) for supplying an amount (105) of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.
摘要:
The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要:
The invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要:
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
摘要:
Methods and apparatuses for analyzing digital pathology images are provided. The methods and apparatuses may provide estimates of staining intensity and proportion score in regions of interest within an image. Digital pathology images may be scored according to these metrics. The methods and apparatuses disclosed herein utilize various predetermined thresholds, parameters, and models to increase efficiency and permit accurate estimation of characteristics of a stained tissue sample.