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公开(公告)号：EP1461308B1
公开(公告)日：2006-12-20
申请号：EP02804264.6
申请日：2002-11-27
发明人： GANE, Paul De Novo Pharmaceuticals Limited , PORTER, Barry De Novo Pharmaceuticals Limited , SAROGLOU, Lydia OSI Pharmaceuticals , WILLEMS, Henriette De Novo Pharmaceuticals Limited , WIJKMANS, Jac NV Organon
IPC分类号： C07C259/06 , A61K31/16 , A61P31/04 , C12Q1/00
CPC分类号： C07C259/06 , C07C2601/08 , C07C2601/14 , C07C2602/08
摘要： Compounds of formula (I), are antibacterial agents, wherein: Z represents a radical of formula -N(OH)CH(=O) or of formula -C(=O)NH(OH); X represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical; n is O or 1; and R represents an optionally substituted carbocyclic or heterocyclic group.
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公开(公告)号：EP1461310A1
公开(公告)日：2004-09-29
申请号：EP02804265.3
申请日：2002-11-27
发明人： GANE, Paul,De Novo Pharmaceuticals Limited , PORTER, Barry,De Novo Pharmaceuticals Limited , WILLEMS, Henriette,De Novo Pharmaceuticals Ltd , BECKETT, Raymond Paul,Emisphere Technologies Inc. , KEAVEY, Kenneth,British Biotech Pharm. Ltd
IPC分类号： C07C275/14 , C07C275/12 , C07C275/24 , C07D213/75 , C07D295/20 , A61K31/17 , A61P31/04
CPC分类号： C07D213/40 , C07C275/24 , C07C2601/08 , C07D295/215
摘要： Compounds of formula (I) are antibacterial agents: wherein: Z is -N(OH)CH(=O) or -C(=O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula -N(OH)CH(=O), a hydroxy, halo or amino group; R2, R3 and R4 independently represents hydrogen or a group R10-(D)n-(ALK)m- wherein R10 , D, n, m and ALK are as defined in the claims; or R3 and R4 taken together with the nitrogen atom to which they are attached form an optionally substituted monocyclic heterocyclic ring containing from 5 to 7 ring atoms, one of which is the nitrogen atom to which R4 and R5 are attached and the remaining ring atoms being selected from compatible combinations of carbon, oxygen, sulfur and nitrogen.
摘要翻译： 式（I）化合物是抗菌剂：其中：Z是-N（OH）CH（-O）或-C（-O）NH（OH）; 除了当Z是式-N（OH）CH（-O），羟基，卤素或氨基的基团时，R 1表示氢，甲基或三氟甲基。 R 2，R 3和R 4独立地表示氢或基团R 10 - （D）
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公开(公告)号：EP1461308A2
公开(公告)日：2004-09-29
申请号：EP02804264.6
申请日：2002-11-27
发明人： GANE, PaulDe Novo Pharmaceuticals Limited , PORTER, BarryDe Novo Pharmaceuticals Limited , SAROGLOU, LydiaOSI Pharmaceuticals , WILLEMS, HenrietteDe Novo Pharmaceuticals Limited , WIJKMANS, JacNV Organon
IPC分类号： C07C259/06 , A61K31/16 , A61P31/04 , C12Q1/00
CPC分类号： C07C259/06 , C07C2601/08 , C07C2601/14 , C07C2602/08
摘要： Compounds of formula (I), are antibacterial agents, wherein: Z represents a radical of formula -N(OH)CH(=O) or of formula -C(=O)NH(OH); X represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical; n is O or 1; and R represents an optionally substituted carbocyclic or heterocyclic group.
摘要翻译： 式（I）化合物是抗菌剂，其中：Z表示基团式-N（OH）CH（-O）或式-C（ - O）NH（OH）; X表示直链或支链二价C 1 -C 6亚烯基或C 2 -C 6亚炔基 ; n为0或1; 并且R表示任选取代的碳环或杂环基。
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公开(公告)号：EP1343753A2
公开(公告)日：2003-09-17
申请号：EP01271376.4
申请日：2001-12-21
发明人： PORTER, Barry , GANE, Paul , BECKETT, Raymond Paul , KEAVEY, Kenneth , WIJKMANS, Jac , SAROGLOU, Lydia
IPC分类号： C07C259/06 , C07D491/04 , C07D215/56 , C07D311/12 , C07D285/10 , C07C311/19 , C07D209/18 , C07D263/12 , C07D217/22 , A61K31/4741 , A61P31/04
CPC分类号： C07D285/10 , C07C259/06 , C07C311/19 , C07D209/18 , C07D215/56 , C07D217/22 , C07D263/12 , C07D311/12 , C07D491/04
摘要： Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(=O) or of formula C(=O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(=O), a hydroxy or amino group; R2 represents a radical of formula R10-(X)n-(ALK)m- wherein R10 represents hydrogen, or an optionally substituted c1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent NH-, -O- or S- linkages, X represents NH-, -O- or S-, and m and n are independently 0 or 1; R3 represents hydrogen, C1-C6alkyl, or benzyl; and R4 is as defined in the specification.
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