公开(公告)号：EP1343753A2

公开(公告)日：2003-09-17

申请号：EP01271376.4

申请日：2001-12-21

申请人： De Novo Pharmaceuticals Ltd.

发明人： PORTER, Barry ,  GANE, Paul ,  BECKETT, Raymond Paul ,  KEAVEY, Kenneth ,  WIJKMANS, Jac ,  SAROGLOU, Lydia

IPC分类号： C07C259/06 ,  C07D491/04 ,  C07D215/56 ,  C07D311/12 ,  C07D285/10 ,  C07C311/19 ,  C07D209/18 ,  C07D263/12 ,  C07D217/22 ,  A61K31/4741 ,  A61P31/04

CPC分类号： C07D285/10 ,  C07C259/06 ,  C07C311/19 ,  C07D209/18 ,  C07D215/56 ,  C07D217/22 ,  C07D263/12 ,  C07D311/12 ,  C07D491/04

摘要： Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(=O) or of formula C(=O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(=O), a hydroxy or amino group; R2 represents a radical of formula R10-(X)n-(ALK)m- wherein R10 represents hydrogen, or an optionally substituted c1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent NH-, -O- or S- linkages, X represents NH-, -O- or S-, and m and n are independently 0 or 1; R3 represents hydrogen, C1-C6alkyl, or benzyl; and R4 is as defined in the specification.