公开(公告)号：EP1654362A2

公开(公告)日：2006-05-10

申请号：EP04780284.8

申请日：2004-08-06

申请人： EYETECH PHARMACEUTICALS, INC.

发明人： ADAMIS, Anthony, P. ,  SHIMA, David ,  WINCOTT, Francine ,  CALIAS, Perry

IPC分类号： C12N15/11 ,  C07H21/04 ,  A61K9/14 ,  A61P9/10

CPC分类号： C12N15/115 ,  A61K9/1635 ,  A61K9/1647 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

摘要： The invention provides compositions and methods for the treating disease using aptamers having 5’-5’and 3’-3’ inverted nucleotide capped ends. In particular, the invention provides 5’-5’ and 3’-3’ capped and-VEGF aptamers of the treatment of neovascularization-related diseases and disorders including age-related macular degeneration.

公开(公告)号：EP1441743A2

公开(公告)日：2004-08-04

申请号：EP02802885.0

申请日：2002-11-08

申请人： Eyetech Pharmaceuticals

发明人： GUYER, David R.

IPC分类号： A61K31/70 ,  C12N5/10 ,  C07H21/00 ,  C12Q1/68

CPC分类号： A61K31/555 ,  A61K31/409 ,  A61K31/7088 ,  A61K31/765 ,  C12Q1/6886

摘要： Disclosed herein are methods for treating ocular neovascular disease using anti-VEGF therapy in combination with a second therapy that inhibits the development of ocular neovascularization or destroys abnormal blood vessels in the eye, such as photodynamic therapy.

公开(公告)号：EP1441743A4

公开(公告)日：2009-02-25

申请号：EP02802885

申请日：2002-11-08

申请人： EYETECH PHARMACEUTICALS

发明人： GUYER DAVID R

IPC分类号： A61F9/007 ,  A61F20060101 ,  A61K31/409 ,  A61K31/70 ,  A61K31/7088 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61N1/30 ,  A61P27/02 ,  A61P43/00 ,  C07H20060101 ,  C07H21/00 ,  C12N5/10 ,  C12Q1/68

CPC分类号： A61K31/555 ,  A61K31/409 ,  A61K31/7088 ,  A61K31/765 ,  C12Q1/6886