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1.发明授权ANTICORPS MONOCLONAL ANTI-AURORA-A, SON PROCEDE D OBTENTION, ET SES UTILISATIONS DANS LE DIAGNOSTIC ET LE TRAITEMENT DES CANCERS 有权单克隆抗体AURORA-A，其制造方法及其使用的诊断和治疗癌症
公开(公告)号：EP1511771B1
公开(公告)日：2009-01-07
申请号：EP03760023.6
申请日：2003-06-12
发明人： PRIGENT, Claude , MARTIN, Anne
IPC分类号： C07K16/32 , C07K16/40 , A61K39/395 , G01N33/577 , A61P35/00
摘要： The invention concerns a monoclonal antibody directed against mammalian aurora-A kinase, the method for obtaining same, as well as its uses in cancer diagnosis and prognosis, and in pharmaceutical compositions for cancer treatment.
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公开(公告)号：EP1572989B1
公开(公告)日：2006-11-22
申请号：EP03814483.8
申请日：2003-12-16
CPC分类号： C12N5/0639 , A61K2035/124 , C12N2501/125 , C12N2501/23 , C12N2501/26
摘要： The invention relates to plasmacytoid dendritic human cell lines (pDC), methods for the production thereof and to said cells. More specifically, said invention relates to the plasmacytoid dendritic human cell line called GEN2.2 which is deposited in CNCM under number CNCM I-2938. The use of said cells and pharmaceutical compounds containing plasmacytoid dendritic human cells (pDC) are also disclosed.
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公开(公告)号：EP1572989A1
公开(公告)日：2005-09-14
申请号：EP03814483.8
申请日：2003-12-16
CPC分类号： C12N5/0639 , A61K2035/124 , C12N2501/125 , C12N2501/23 , C12N2501/26
摘要： The invention relates to plasmacytoid dendritic human cell lines (pDC), methods for the production thereof and to said cells. More specifically, said invention relates to the plasmacytoid dendritic human cell line called GEN2.2 which is deposited in CNCM under number CNCM I-2938. The use of said cells and pharmaceutical compounds containing plasmacytoid dendritic human cells (pDC) are also disclosed.
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4.发明公开A membrane based microarray device for high-throughput multianalyte detection 审中-公开膜Mik te Mik ray ung ung ung ung ung fs fs fs fs fs fs fs fs fs fs fs
公开(公告)号：EP2278334A1
公开(公告)日：2011-01-26
申请号：EP09356049.8
申请日：2009-07-22
申请人： Etablissement Francais du Sang , UNIVERSITE CLAUDE BERNARD , Centre National de la Recherche Scientifique , ECOLE NORMALE SUPERIEURE DE LYON
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/543 , B01J2219/00295 , B01J2219/00423 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/50255 , B01L2300/0636 , B01L2300/0829 , C40B60/12 , G01N33/54366 , G01N33/548
摘要： A device - for performing an assay- comprising a substantially rigid support forming at least one well defining an inner cavity, having a bottom wall provided with a hole, a porous membrane sealed onto the support closing said hole and having an inner surface oriented towards the inside of the cavity and an opposite outer surface, at least one probe immobilized on the membrane, characterized in that the probe is immobilized outside the cavity and on the outer surface of the membrane.
摘要翻译： 一种用于执行测定的装置，包括形成限定内腔的至少一个阱的基本上刚性的支撑件，具有设置有孔的底壁，密封在所述支撑件上的多孔膜，所述多孔膜封闭所述孔并且具有朝向所述孔的内表面 在腔的内部和相对的外表面中，固定在膜上的至少一个探针，其特征在于，探针固定在腔的外部和膜的外表面上。
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5.发明公开A MEMBRANE BASED MICROARRAY DEVICE FOR HIGH-THROUGHPUT MULTIANALYTE DETECTION 审中-公开基于膜的微阵列装置进行高通量MULTIANALYTDETEKTION WITH
公开(公告)号：EP2457094A1
公开(公告)日：2012-05-30
申请号：EP10735276.7
申请日：2010-07-21
申请人： Etablissement Francais Du Sang , Universite Claude Bernard , Centre National de la Recherche Scientifique (C.N.R.S.) , ECOLE NORMALE SUPERIEURE DE LYON
IPC分类号： G01N33/543 , B01L3/00 , B01D67/00 , B01D69/14
CPC分类号： G01N33/543 , B01J2219/00295 , B01J2219/00423 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/50255 , B01L2300/0636 , B01L2300/0829 , C40B60/12 , G01N33/54366 , G01N33/548
摘要： A device – for performing an assay-comprising a substantially rigid support forming at least one well defining an inner cavity, having a bottom wall provided with a hole, a porous membrane sealed onto the support closing said hole and having an inner surface oriented towards the inside of the cavity and an opposite outer surface, at least one probe embedded within the porous membrane so as to immobilize the probe within the membrane.
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公开(公告)号：EP2383572A1
公开(公告)日：2011-11-02
申请号：EP10358003.1
申请日：2010-04-28
申请人： Assistance Publique Hôpitaux de Marseille , Université de la Méditerranée (Aix-Marseille II) , Etablissement Francais du Sang
IPC分类号： G01N33/50 , G01N33/564 , G01N33/566
CPC分类号： G01N33/5047 , G01N2333/70535 , G01N2333/7158 , G01N2800/245
摘要： The present invention concerns an in vitro method for determining a subject cellular humoral activity, which comprises the step of (ii) determining the expression profile of at least the CX3CR1 gene in effector cells expressing FCRG and CX3CR1, preferably CD3 - CD56 + NK cells, and (iii) comparing said expression profile to at least one control such as control values of FCRG and CX3CR1 expressing subsets in representative healthy donor control cohorts; the associated kit and the use of said kit for determining a subject cellular humoral activity directed against an antigen.
摘要翻译： 本发明涉及用于确定受试者细胞体液活性的体外方法，其包括以下步骤：（ii）测定表达FCRG和CX3CR1，优选CD3-CD56 + NK细胞的效应细胞中至少CX3CR1基因的表达谱， 和（iii）将所述表达谱与代表健康供体对照组中的至少一个对照比如表达FCRG和CX3CR1表达子集的对照值进行比较; 相关试剂盒和所述试剂盒用于确定针对抗原的受试细胞体液活性的用途。
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7.发明公开LIGNÉE DE CELLULES DENDRITIQUES PLASMACYTOÏDES UTILISÉE EN THÉRAPIE CELLULAIRE ACTIVE OU ADOPTIVE 有权ER IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE IE
公开(公告)号：EP2276832A1
公开(公告)日：2011-01-26
申请号：EP09745821.0
申请日：2009-05-15
CPC分类号： C12N5/0639 , A61K2035/124 , A61K2039/5154 , A61K2039/5158
摘要： The present invention relates to a method for inducing and amplifying specific effectors, which comprises obtaining pulsed plasmacytoid dendritic cells (pDC) by incubation of a pDC line with at least one antigen, the pulsed pDC being subsequently irradiated and brought into contact with peripheral blood mononuclear cells (PBMC), and cultured or injected into an organism. The pulsed and irradiated pDC and the PBMC share at least one major histocompatibility complex (MHC) allele.
摘要翻译： 本发明涉及一种用于诱导和扩增特异性效应子的方法，其包括通过将pDC系与至少一种抗原孵育获得脉冲浆细胞样树突状细胞（pDC），脉冲式pDC随后被照射并与外周血单核细胞接触 细胞（PBMC），并培养或注射到生物体中。 脉冲和照射的pDC和PBMC共享至少一种主要的组织相容性复合体（MHC）等位基因。
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8.发明公开UTILISATION DE FILTRES DE DÉLEUCOCYTATION POUR LA PURIFICATION DE DÉFENSINES 有权DELEUKOZYTATIONSFILTERN的净化防御用途
公开(公告)号：EP1999145A1
公开(公告)日：2008-12-10
申请号：EP07731833.5
申请日：2007-03-27
CPC分类号： C07K14/4723 , A61M1/3496
摘要： The invention concerns the use of deleucocytation filters for defensin purification. More precisely, the invention concerns a method for purifying defensins, including the following steps: passing a blood sample on a deleucocytation filter; detaching the cells retained on the deleucocytation filter; inducing exocytosis of the defensins by those cells.
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9.发明公开ANTICORPS MONOCLONAL ANTI-AURORA-A, SON PROCEDE D OBTENTION, ET SES UTILISATIONS DANS LE DIAGNOSTIC ET LE TRAITEMENT DES CANCERS 有权单克隆抗体AURORA-A，其制造方法及其使用的诊断和治疗癌症
公开(公告)号：EP1511771A1
公开(公告)日：2005-03-09
申请号：EP03760023.6
申请日：2003-06-12
发明人： PRIGENT, Claude , MARTIN, Anne
IPC分类号： C07K16/32 , C07K16/40 , A61K39/395 , G01N33/577 , A61P35/00
摘要： The invention concerns a monoclonal antibody directed against mammalian aurora-A kinase, the method for obtaining same, as well as its uses in cancer diagnosis and prognosis, and in pharmaceutical compositions for cancer treatment.
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