公开(公告)号：EP3127557A1

公开(公告)日：2017-02-08

申请号：EP16020296.6

申请日：2016-08-05

申请人： TERES S.r.l. ,  Fraschini, Franco Luigi ,  Fumagalli, Marco Carlo ,  Alpha Strumenti S.r.l.

发明人： Ceschel, Giancarlo Antonio Renato

IPC分类号： A61K47/10 ,  A61K9/06 ,  A61K31/00 ,  A61P35/00 ,  A61K41/00

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/00 ,  A61K41/0061 ,  A61K47/10

摘要： An ALA-gel vehicle for favoring an absorption and conveying of an active principle for a topic use in particular in a photodynamic therapy with delta-aminolevulinic acid in dermatologic applications, said vehicle comprising a clear aqueous solution jelling at a temperature from 20 to 37°C, preferably from 25 to 27°C, of the following components: poloxamer 407 (Lutrol 127) as a vehicle-gel either per se or in a mixture with one or more of the poloxamers having the following structural formula:

said vehicle comprising moreover potassium sorbate and sodium benzoate as preserving agents, 5-amminolevunic chloridrate as a precursor agent for providing a target photodynamic reaction, and purified water.

摘要翻译： 为用于与在皮肤病应用δ-氨基乙酰丙酸光动力治疗中particulare主题使用的活性成分的吸收和输送有利于ALA-凝胶车辆，所述车辆，包括澄清溶液wässrige在20的温度下胶凝至37° 左右，优选为25至27℃时，以下部分组成：泊洛沙姆407（的Lutrol 127），为车辆 - 凝胶本身或与一种或多种具有以下结构式的泊洛沙姆的混合物：所述车辆，包括多个在 山梨酸钾和苯甲酸钠作为防腐剂，5- amminolevunic氯化物速率作为用于提供目标光动力反应的前体剂和纯净水。