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1.发明公开NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES 审中-公开新化合物呼吸兴奋剂呼吸疾病控制问题或的治疗
公开(公告)号：EP2646423A4
公开(公告)日：2014-04-30
申请号：EP11845815
申请日：2011-11-29
发明人： DAX SCOTT L , WOODWARD RICHARD , PENG SEAN
IPC分类号： C07D251/54 , A61K31/53 , A61P11/00
CPC分类号： A61K31/53 , A61K31/505 , A61K31/519 , A61K31/522 , A61K31/5355 , A61K31/57 , A61K45/06 , A61M16/0465 , A61M16/06 , C07D239/50 , C07D251/66 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D487/04 , C07D498/06
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2.发明公开
公开(公告)号：EP2968329A4
公开(公告)日：2016-09-28
申请号：EP14768540
申请日：2014-03-13
发明人： DAX SCOTT , MENCEL JAMES JOSEPH , OZOLA VITA , SHUBIN KIRILL , MARTJUGA MARINA , SUNA EDGARS
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00 , C07D257/12
CPC分类号： C07D487/04 , A61K9/48 , A61K9/4891 , A61K9/5084 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.
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公开(公告)号：EP2544542A4
公开(公告)日：2013-07-24
申请号：EP11753938
申请日：2011-03-08
发明人： MANNION JAMES C , DAX SCOTT L
IPC分类号： C07D277/18 , A61K31/425 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/04 , A61P25/28 , A61P25/30 , A61P29/00 , A61P35/00
CPC分类号： C07D277/18
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公开(公告)号：EP2068903A2
公开(公告)日：2009-06-17
申请号：EP07852518.5
申请日：2007-10-03
发明人： MANNION, James C.
IPC分类号： A61K38/00
CPC分类号： A61K31/4015 , A61K31/167 , A61K31/198 , A61K31/221 , A61K31/401 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/496 , A61K31/5375 , A61K2300/00
摘要： The present invention is directed to a method of treating a lack of normal breathing control including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions. In an aspect, the invention is directed to treating disordered control of breathing by administering an composition comprising a single compound which treats lack of normal breathing. In another aspect, the invention is directed to treating disordered control of breathing by administering an composition comprising a combination of two or more compounds, at least one of which treats lack of normal breathing. In an aspect, a compound is an S-nitrosylating agent.
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5.发明公开NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME 审中-公开新型BEATMUNGSSTEUERUNGSMODULIERENDE化合物及其使用方法
公开(公告)号：EP2968329A1
公开(公告)日：2016-01-20
申请号：EP14768540.8
申请日：2014-03-13
发明人： DAX, Scott , MENCEL, James Joseph , OZOLA, Vita , SHUBIN, Kirill , MARTJUGA, Marina , SUNA, Edgars
IPC分类号： A61K31/505 , A61P11/00 , C07D257/12
CPC分类号： C07D487/04 , A61K9/48 , A61K9/4891 , A61K9/5084 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.
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6.发明公开NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES 审中-公开新颖的化合物，COMPOSITIONS FOR呼吸控制的问题或疾病的治疗
公开(公告)号：EP2855438A2
公开(公告)日：2015-04-08
申请号：EP13798039.7
申请日：2013-05-29
发明人： MANNION, James, C. , DAX, Scott, L. , MACINTYRE, Duncan, Euan , GOLDER, Francis, John , MCLEOD, James, Francis
IPC分类号： C07D251/54
CPC分类号： A61K31/505 , A61K31/433 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/5355 , A61K31/57 , A61K45/06 , C07D239/50 , C07D251/54 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D471/08 , C07D487/04 , C07D498/08 , C07D519/00 , A61K2300/00
摘要： The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.
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公开(公告)号：EP2544542A1
公开(公告)日：2013-01-16
申请号：EP11753938.7
申请日：2011-03-08
发明人： MANNION, James, C. , DAX, Scott, L.
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D277/18
摘要： The invention relates to compounds, compositions, and methods for diminishing pain in a subject in need thereof comprising administering the compounds and compositions herein described.
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公开(公告)号：EP2068903A4
公开(公告)日：2010-11-03
申请号：EP07852518
申请日：2007-10-03
发明人： MANNION JAMES C
IPC分类号： A61K31/167 , A61K31/198 , A61K31/221 , A61K31/401 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/496 , A61K31/5375 , A61P11/00
CPC分类号： A61K31/4015 , A61K31/167 , A61K31/198 , A61K31/221 , A61K31/401 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/496 , A61K31/5375 , A61K2300/00
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9.发明公开NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES 审中-公开新颖的化合物，COMPOSITIONS FOR呼吸控制的问题或疾病的治疗
公开(公告)号：EP2855438A4
公开(公告)日：2016-02-24
申请号：EP13798039
申请日：2013-05-29
发明人： MANNION JAMES C , DAX SCOTT L , MACINTYRE DUNCAN EUAN , GOLDER FRANCIS JOHN , MCLEOD JAMES FRANCIS
IPC分类号： C07D251/54 , A61K31/53 , A61K45/06 , A61P11/00
CPC分类号： A61K31/505 , A61K31/433 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/5355 , A61K31/57 , A61K45/06 , C07D239/50 , C07D251/54 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D471/08 , C07D487/04 , C07D498/08 , C07D519/00 , A61K2300/00
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10.发明公开NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME 审中-公开小说，口服生物利用度，ATEMKONTROLLEMODULIERENDE化合物和其使用方法
公开(公告)号：EP2920155A2
公开(公告)日：2015-09-23
申请号：EP13854758.3
申请日：2013-11-14
发明人： MANNION, James C. , DAX, Scott L. , GOLDER, Francis John , MACINTYRE, Duncan Euan , MCLEOD, James , OZOLA, Vita , SUNA, Edgars , SHUBIN, Kirill , MENCEL, James Joseph , PENG, Sean X.
IPC分类号： C07D251/54
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D251/54 , C07D251/70 , C07D473/16
摘要： The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.
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