利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.01 秒)

    GENERATION OF MUSCLE-LINEAGE CELLS FROM STEM CELLS
    2.
    发明公开
    GENERATION OF MUSCLE-LINEAGE CELLS FROM STEM CELLS 审中-公开

    公开(公告)号：EP3286301A1

    公开(公告)日：2018-02-28

    申请号：EP16782394

    申请日：2016-04-22

    申请人： GENEA IP HOLDINGS PTY LTD

    发明人： SCHMIDT ULI ,  CARON LESLIE

    IPC分类号： C12N5/077 ,  A61K35/34 ,  C12N5/02

    CPC分类号： A61K35/34 ,  A61K35/545 ,  C12N5/0658 ,  C12N2510/00

    摘要： Methods and compositions for producing cells expressing CD56/Pax3, CD56Pax7, and/or Pax3/Pax7 are provided herein. In some instances, the method involves contacting a pluripotent stem cell in an in vitro culture with one compound, or with two or more compounds at the same time, wherein the contacting the pluripotent stem cell in the in vitro culture with one compound, or with two or more compounds at the same time, directly results in generation of cells expressing CD56/Pax3, CD56/Pax7, or Pax3/Pax7. Also provided are methods of using the generated cells. Typically one of the compounds is a wnt pathway activator, such as the GSK3 inhibitor CHIR99021.