公开(公告)号：EP0865276A1

公开(公告)日：1998-09-23

申请号：EP96923658.0

申请日：1996-07-05

申请人： Gilad, Gad ,  Gilad, Varda

发明人： GILAD, Gad ,  GILAD, Varda ,  STERLING, Jeffrey ,  HERZIG, Yaacov ,  LERNER, David ,  VEINBERG, Alex ,  MILMAN, Isaac ,  FINKELSTEIN, Nina

IPC分类号： A61K31 ,  C07C211 ,  C07C233 ,  C07C279

CPC分类号： C07C279/12 ,  A61K31/135 ,  A61K31/155 ,  C07C211/42 ,  C07C233/41 ,  C07C2602/24

摘要： A compound of general formula (I), wherein n is 1 or 2; R1 and R2 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy or halogeno; R5 is hydrogen, substituted or unsubstituted C1-4 alkyl, amino or NR6R7; R3, R4, R6 and R7 are each independently hydrogen or (CH2)m-[NH(CH2)x]y-NHR11 wherein m is from 0-5, y is from 0-5 and each x is independently from 1-5 and R11 is hydrogen or C(NH)NH2; provided that when R3 and R4 are both hydrogen, R5 is amino or NR6R7; pharmaceutically acceptable salts and optically active isomers thereof.

公开(公告)号：EP0865276A4

公开(公告)日：2003-07-30

申请号：EP96923658

申请日：1996-07-05

申请人： GILAD GAD ,  GILAD VARDA

发明人： GILAD GAD ,  GILAD VARDA ,  STERLING JEFFREY ,  HERZIG YAACOV ,  LERNER DAVID ,  VEINBERG ALEX ,  MILMAN ISAAC ,  FINKELSTEIN NINA

IPC分类号： A61K31/135 ,  A61K31/155 ,  C07C211/42 ,  C07C233/41 ,  C07C279/12 ,  A61K31/15 ,  C07C243/20 ,  C07C247/14 ,  C07C281/16

CPC分类号： C07C279/12 ,  A61K31/135 ,  A61K31/155 ,  C07C211/42 ,  C07C233/41 ,  C07C2602/24