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1.发明授权
公开(公告)号：EP1133286B1
公开(公告)日：2004-11-24
申请号：EP99959320.5
申请日：1999-11-24
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K31/22 , A61K31/355 , A61K31/575 , Y10S977/775 , Y10S977/783 , Y10S977/797 , Y10S977/798 , Y10S977/801 , Y10S977/912 , Y10S977/915
摘要： The present invention relates to pharmaceutical compositions in form of solid lipidic nanospheres able to fast penetrate into the cells, comprising as an active substance a lipidic substance consisting of an ester of α-tocopherol or δ-tocopherol or of cholesterol or of glycerol with a carboxylic acid selected from acetic acid, propionic acid, butyric acid and succinic acid, useful in the treatment of tumoral pathologies and of Mediterranean anaemia.
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2.发明公开Solid lipid microspheres having a narrow size distribution and method for producing them 失效Feste Lipid-Mikrokugeln mit enger korngrosser Verteilung und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0526666A1
公开(公告)日：1993-02-10
申请号：EP91113152.2
申请日：1991-08-05
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , Y10T428/2984 , Y10T428/2989
摘要： Solid lipid microspheres having a diameter lower than one micron and a polydispersion of between 0.06 and 0.90 obtained by adding to a molten lipid substance a mixture consisting of water, a surfactant and possibly a co-surfactant, dispersing in water the obtained microemulsion, washing with water the dispersion microspheres by diafiltration and lyophilizing.
摘要翻译： 通过向熔融脂质物质中加入由水，表面活性剂和可能的助表面活性剂组成的混合物，将所得微乳液分散在水中，将其洗涤，得到直径小于1微米，多分散体为0.06〜0.90的固体脂质微球 通过渗滤和冻干将水分散在微球中。
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3.发明授权PHARMACEUTICAL COMPOSITION IN FORM OF SOLID LIPIDIC MICROPARTICLES SUITABLE TO PARENTERAL ADMINISTRATION 失效药物形式PARENENTERAL给药的脂质微粒
公开(公告)号：EP0988031B1
公开(公告)日：2003-04-02
申请号：EP98929383.2
申请日：1998-05-27
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
CPC分类号： A61K9/5123
摘要： Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration containing a drug and one or more substances suitable to sterically stabilize said microparticles.
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4.发明授权
公开(公告)号：EP1071408B1
公开(公告)日：2005-09-07
申请号：EP98965704.4
申请日：1998-11-27
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
CPC分类号： A61K31/7036 , A61K9/19 , A61K9/5123 , A61K38/23 , Y10S514/937 , Y10S514/941 , Y10S977/924
摘要： Pharmaceutical composition comprising microparticles having an average diameter ranging from 40 to 150 nm, consisting of one or more lipids, a drug and, optionally, a steric stabilizer, suitable to the transmucosal passage and to the overcoming of the blood-brain barrier and the blood-cerebrospinal fluid barrier, said microparticles being obtained dispersing in an aqueous medium cooled to 2-4 DEG C an oil/water or a water/oil/water microemulsion comprising said constituents.
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5.发明公开
公开(公告)号：EP1133286A1
公开(公告)日：2001-09-19
申请号：EP99959320.5
申请日：1999-11-24
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K31/22 , A61K31/355 , A61K31/575 , Y10S977/775 , Y10S977/783 , Y10S977/797 , Y10S977/798 , Y10S977/801 , Y10S977/912 , Y10S977/915
摘要： The present invention relates to pharmaceutical compositions in form of solid lipidic nanospheres able to fast penetrate into the cells, comprising as an active substance a lipidic substance consisting of an ester of α-tocopherol or δ-tocopherol or of cholesterol or of glycerol with a carboxylic acid selected from acetic acid, propionic acid, butyric acid and succinic acid, useful in the treatment of tumoral pathologies and of Mediterranean anaemia.
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6.发明公开
公开(公告)号：EP1071408A1
公开(公告)日：2001-01-31
申请号：EP98965704.4
申请日：1998-11-27
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
CPC分类号： A61K31/7036 , A61K9/19 , A61K9/5123 , A61K38/23 , Y10S514/937 , Y10S514/941 , Y10S977/924
摘要： Pharmaceutical composition comprising microparticles having an average diameter ranging from 40 to 150 nm, consisting of one or more lipids, a drug and, optionally, a steric stabilizer, suitable to the transmucosal passage and to the overcoming of the blood-brain barrier and the blood-cerebrospinal fluid barrier, said microparticles being obtained dispersing in an aqueous medium cooled to 2-4 °C an oil/water or a water/oil/water microemulsion comprising said constituents.
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7.发明公开PHARMACEUTICAL COMPOSITION IN FORM OF SOLID LIPIDIC MICROPARTICLES SUITABLE TO PARENTERAL ADMINISTRATION 失效药物形式PARENENTERAL给药的脂质微粒
公开(公告)号：EP0988031A1
公开(公告)日：2000-03-29
申请号：EP98929383.2
申请日：1998-05-27
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
CPC分类号： A61K9/5123
摘要： Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration containing a drug and one or more substances suitable to sterically stabilize said microparticles.
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8.发明授权
公开(公告)号：EP1567125B1
公开(公告)日：2009-01-14
申请号：EP03809756.4
申请日：2003-10-31
CPC分类号： A61K9/0048
摘要： Pharmaceutical compositions for the treatment of ophthalmic diseases, suitable for topical ocular administration and for systemic administration, comprising solid lipid nanoparticles (SLNs) with a mean diameter comprised between 50 and 400 nm wherein, within said nanoparticles, a pharmacologically active substance for the specific ophthalmic treatment is incorporated.
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9.发明公开LIPID NANOPARTICLES AS VEHICLES FOR NUCLEIC ACIDS, PROCESS FOR THEIR PREPARATION AND USE 审中-公开脂质纳米粒为载体对于核酸和其生产和使用
公开(公告)号：EP1761251A1
公开(公告)日：2007-03-14
申请号：EP05753963.7
申请日：2005-06-08
申请人： Gasco, Maria Rosa
发明人： Gasco, Maria Rosa
CPC分类号： A61K48/0008 , A61K9/5123 , A61K9/5192
摘要： The present invention relates to solid lipid nanoparticles composed of lipid material and containing, as bioactive molecule, a nucleic acid, preferably an antisense oligonucleotide, preferably modified by chemical methods to achieve a greater resistance to endo- and exo-nucleases, and to the process for preparation of said nanoparticles. In the present invention, the efficiency of the delivery system represented by nanoparticles containing synthetic or natural polynucleotides allows the use of such system for transfection. Said particles are especially effective in the treatment of diseases of the posterior segment of the eye (such as diabetic retinopathy, macular degeneration, etc.) and in angiogenesis.
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10.发明公开
公开(公告)号：EP1567125A2
公开(公告)日：2005-08-31
申请号：EP03809756.4
申请日：2003-10-31
CPC分类号： A61K9/0048
摘要： Pharmaceutical compositions for the treatment of ophthalmic diseases, suitable for topical ocular administration and for systemic administration, comprising solid lipid nanoparticles (SLNs) with a mean diameter comprised between 50 and 400 nm wherein, within said nanoparticles, a pharmacologically active substance for the specific ophthalmic treatment is incorporated.
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