公开(公告)号：EP2970443A4

公开(公告)日：2017-01-11

申请号：EP14770483

申请日：2014-03-14

申请人： GILL PARKASH S ,  LIU REN

发明人： GILL PARKASH S ,  LIU REN

IPC分类号： C07K16/00 ,  A61K39/00 ,  A61K39/395 ,  C12P21/08

CPC分类号： C07K16/28 ,  A61K47/48384 ,  A61K47/48569 ,  A61K47/48753 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6898 ,  A61K49/0032 ,  A61K49/0058 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492 ,  G01N2333/705

摘要： This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

摘要翻译： 此应用程序提供，除其他外，抗体或抗原结合片段，其靶向过度表达于肿瘤细胞，肿瘤内皮细胞和肿瘤启动癌细胞的细胞表面GRP78。 这些抗GRP78抗体，或其抗原结合片段，其具有用于GRP78具有高亲和力并且是免疫原性更低相比，在给定的物种及其未修饰的亲本抗体，E. G.，人，并且起抑制GRP78。 重要的是，本文新的分离的抗体和抗原结合片段，其减弱PI3K信号传导和促进肿瘤细胞凋亡，而对正常细胞不受影响。 的抗体和抗原结合片段可用于UPR-靶向癌症的治疗性处理是有用的。

公开(公告)号：EP2970443A2

公开(公告)日：2016-01-20

申请号：EP14770483.7

申请日：2014-03-14

申请人： Gill, Parkash, S. ,  Liu, Ren

发明人： Gill, Parkash, S. ,  Liu, Ren

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6898 ,  A61K49/0032 ,  A61K49/0058 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492 ,  G01N2333/705

摘要： This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

公开(公告)号：EP1564292A1

公开(公告)日：2005-08-17

申请号：EP04105588.0

申请日：2001-01-19

申请人： Gill, Parkash, S.

发明人： Gill, Parkash, S. ,  Masood, Rizwan

IPC分类号： C12N15/11 ,  A61K48/00 ,  G01N33/50

CPC分类号： C12N15/1136 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： This invention relates to compositions and methods for inhibition of abnormal proliferation of cells or angiogenesis. More particularly this invention provides VEGF antisense oligonucleotides capable of inhibiting proliferation of cancer cells or angiogenesis or combinations thereof.

摘要翻译： 本发明涉及抑制细胞异常增殖或血管发生的组合物和方法。 更具体地，本发明提供能够抑制癌细胞增殖或血管生成或其组合的VEGF反义寡核苷酸。

公开(公告)号：EP1252308A2

公开(公告)日：2002-10-30

申请号：EP01942565.1

申请日：2001-01-19

申请人： Gill, Parkash, S.

发明人： GILL, Parkash, S. ,  MASOOD, Rizwan

IPC分类号： C12N15/11

CPC分类号： C12N15/1136 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： This invention relates to compositions and methods for inhibition of abnormal proliferation of cells or angiogenesis. More particularly this invention provides VEGF antisense oligonucleotides capable of inhibiting proliferation of cancer cells or angiogenesis or combinations thereof. Also provided are screening and prognostic assays, as well kits comprising the VEGF antisense oligonucleotides.

公开(公告)号：EP1097165A4

公开(公告)日：2001-09-12

申请号：EP99935517

申请日：1999-07-12

申请人： GILL PARKASH S

发明人： GILL PARKASH S

IPC分类号： C12N15/09 ,  A61K9/06 ,  A61K9/08 ,  A61K38/00 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  C07K4/00 ,  C07K4/12 ,  C07K14/21 ,  C07K14/47 ,  C07K14/475 ,  C07K14/515 ,  C07K16/18 ,  C07K19/00 ,  A61K38/02 ,  A61K38/03 ,  A61K38/16 ,  C07K7/06 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

公开(公告)号：EP1097165A1

公开(公告)日：2001-05-09

申请号：EP99935517.5

申请日：1999-07-12

申请人： Gill, Parkash, S.

发明人： Gill, Parkash, S.

IPC分类号： C07K4/00 ,  C07K4/12 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705 ,  C07K16/18 ,  A61K38/02 ,  A61K38/03 ,  A61K38/16

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

摘要： This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of sphingolipids. In addition, methods of treating mammals with these anti-angiogenic polypeptides are provided, as well as the pharmaceutical compositions used to treat. Furthermore, the polypeptides of this invention can be used in fusion proteins, wherein the fusion proteins also comprise cell targeting or cytotoxic moieties. Also provided is the receptor to which these polypeptides bind.