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公开(公告)号：EP4440625A1
公开(公告)日：2024-10-09
申请号：EP22844698.5
申请日：2022-11-30
CPC分类号： A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/28 , A61K47/68033
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2.发明公开
公开(公告)号：EP4412659A1
公开(公告)日：2024-08-14
申请号：EP22802024.4
申请日：2022-10-06
申请人： Sanofi
IPC分类号： A61K47/68 , C07D471/04 , A61P35/00
CPC分类号： A61P35/00 , C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6849 , A61K47/6853 , C07K16/2827 , C07K16/2866 , C07K16/32 , C07K16/3007 , C07K16/2863 , C07K2317/7620130101 , C07K2317/2120130101 , C07K2317/2420130101
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3.发明公开
公开(公告)号：EP4406606A2
公开(公告)日：2024-07-31
申请号：EP24168990.0
申请日：2016-06-20
发明人： LERCHEN, Hans-Georg , REBSTOCK, Anne-Sophie , CANCHO GRANDE, Yolanda , MARX, Leo , STELTE-LUDWIG, Beatrix , TERJUNG, Carsten , MAHLERT, Christoph , GREVEN, Simone , SOMMER, Anette , BERNDT, Sandra
IPC分类号： A61P35/00
CPC分类号： A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6803 , A61K31/4025 , A61K31/4439 , A61P35/00 , A61P43/00
摘要： Die vorliegende Anmeldung betrifft neuartige Binder-Prodrug-Konjugate (APDCs), bei denen Binder mit inaktiven Vorläuferverbindungen von Kinesin Spindel Protein-Inhibitoren konjugiert werden, sowie Antikörper-Wirkstoff-Konjugate ADCs und Verfahren zur Herstellung dieser APDCs bzw. ADCs.
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公开(公告)号：EP4398942A1
公开(公告)日：2024-07-17
申请号：EP22866845.5
申请日：2022-09-07
发明人： FISHKIN, Nathan , BAI, Chen , TAKROURI, Khuloud , PARK, Peter U.
CPC分类号： A61P35/00 , A61K47/6869 , A61K47/6889 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6867
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公开(公告)号：EP4392462A1
公开(公告)日：2024-07-03
申请号：EP22859754.8
申请日：2022-08-26
发明人： BEAUDOIN, Simon
IPC分类号： C07K17/04 , A61K8/02 , A61K8/64 , A61K9/06 , A61K47/42 , C07J75/00 , C07K1/107 , C07K7/08 , C07K14/00
CPC分类号： A61K8/64 , A61K9/06 , C07K7/08 , C07K19/00 , A61K8/042 , A61K8/63 , A61Q19/00 , C07K14/435 , C07K2319/0920130101 , A61K47/6803 , A61K47/554
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公开(公告)号：EP4376895A2
公开(公告)日：2024-06-05
申请号：EP22761315.5
申请日：2022-07-28
发明人： NITTOLI, Thomas
IPC分类号： A61K47/68 , A61P31/16 , C07D471/04 , C07K16/10
CPC分类号： C07D471/04 , C07K16/1018 , A61K47/6803 , A61K47/6841 , A61P31/16 , C07D519/00
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公开(公告)号：EP3500595B1
公开(公告)日：2024-05-01
申请号：EP17757849.9
申请日：2017-08-18
CPC分类号： C07K16/3069 , C07K2317/2420130101 , C07K2317/7320130101 , C07K2317/9220130101 , C07K2317/9420130101 , A61K47/6803 , A61K47/6869 , A61P13/08 , A61P35/00
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公开(公告)号：EP3411075A1
公开(公告)日：2018-12-12
申请号：EP17704968.1
申请日：2017-02-03
发明人： VEIBY, Ole Peter , CHARI, Ravi, V. J. , LAMBERT, John M. , LAI, Katharine C. , HERBST, Robert W. , HILDERBRAND, Scott A.
CPC分类号： A61K47/6871 , A61K47/6803 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： This invention relates to antibody-drug conjugates capable of delivering cytotoxic compounds to cancers expressing the guanylyl cyclase C (GCC) transmembrane cell surface receptor.
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9.发明公开
公开(公告)号：EP3411074A2
公开(公告)日：2018-12-12
申请号：EP16715987.0
申请日：2016-02-04
发明人： ZHAO, Robert Yongxin , YANG, Qingliang , HUANG, Yuanyuan , GAI, Shun , ZHAO, Linyao , YE, Hangbo , GUO, Huihui , TONG, qianqian , CAO, Minjun , JIA, Junxiang , YANG, Chengyu , LI, Wenjun , ZHOU, Xiaomai , XIE, Hongsheng , LIN, Chen , GUO, Zhixiang , YE, Zhicang
IPC分类号： A61K47/48 , C07D417/14 , C07D339/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K49/0058 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6829 , A61K47/6889 , A61K49/0021 , A61K49/0032 , A61K49/0043 , C07D207/08 , C07D277/56 , C07D417/12 , C07D417/14 , C07D498/18 , C07D513/22 , C07D519/00
摘要： The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)- butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
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公开(公告)号：EP3411069A2
公开(公告)日：2018-12-12
申请号：EP17748229.6
申请日：2017-02-03
发明人： KIM, Chanhyuk , YOUNG, Travis , KIM, Minsoo , MA, Jennifer , PRESTA, Leonard , SCHULTZ, Peter G.
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/13
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K47/6869 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The present invention provides for humanized anti-CD3 antibodies and conjugates thereof. These conjugates may be useful in the treatment of conditions such as prostate cancer.
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