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    FLUIDIC CULTURE DEVICE
    4.
    发明公开
    FLUIDIC CULTURE DEVICE 有权
    液体培养装置

    公开(公告)号：EP2358472A1

    公开(公告)日：2011-08-24

    申请号：EP09826366.8

    申请日：2009-11-06

    申请人： Gradientech Ab

    发明人： KREUGER, Johan ,  THORSLUND, Sara ,  BARKEFORS, Irmeli

    IPC分类号： B01L3/00 ,  B81B7/00 ,  C12M1/16 ,  C12M3/00

    CPC分类号： C12M23/16 ,  B01L3/5027 ,  C12M23/10 ,  C12M23/22 ,  C12M25/14 ,  C12M29/10

    摘要： A fluidic culture device (100) comprises a substrate (101) of transparent polymer material with an open culture chamber (110) in the form of a hollow in a bottom surface (102) of the substrate (101). Open fluid channels (120, 130) flank the culture chamber (110) and have inlets (140, 150) and outlets (160) in a top or end surface (104, 106) of the substrate (101). Removable channel plugs (180, 190) are temporarily arranged in the portions of the fluid channels (120, 130) adjacent the culture chamber (110) to prevent culture matrix material poured into the culture chamber (110) from entering and blocking the fluid channels (120, 130). When assembling an operational culture system (230), a biological sample (210) is introduced in the culture matrix (200) and the channel plugs (180, 190) are removed. A transparent cover disk (220) is reversibly attached to the bottom surface (102) to enclose the culture chamber (110) and the fluid channels (120, 130). A gradient is established over the culture chamber (110) by entering fluids having different concentrations of a substance in the fluid channels (120, 130).

    NEW USE OF A FLUIDIC DEVICE
    5.
    发明公开
    NEW USE OF A FLUIDIC DEVICE 有权
    流体设备的新用途

    公开(公告)号：EP3019625A4

    公开(公告)日：2017-03-15

    申请号：EP14823735

    申请日：2014-07-10

    申请人： GRADIENTECH AB

    发明人： KREUGER JOHAN ,  THORSLUND SARA ,  WU ZHIGANG

    IPC分类号： C12Q1/18 ,  B01L3/00 ,  C12M1/12 ,  C12M3/06

    CPC分类号： C12Q1/18 ,  B01L3/5027 ,  C12M23/16 ,  C12M25/14

    摘要： A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).

    NEW USE OF A FLUIDIC DEVICE
    6.
    发明公开
    NEW USE OF A FLUIDIC DEVICE 有权
    NEER VERWENDUNG EINER FLUIDISCHEN VORRICHTUNG

    公开(公告)号：EP3019625A1

    公开(公告)日：2016-05-18

    申请号：EP14823735.7

    申请日：2014-07-10

    申请人： Gradientech AB

    发明人： KREUGER, Johan ,  THORSLUND, Sara ,  WU, Zhigang

    IPC分类号： C12Q1/04 ,  B01L3/00 ,  C12M1/00

    CPC分类号： C12Q1/18 ,  B01L3/5027 ,  C12M23/16 ,  C12M25/14

    摘要： A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).

    摘要翻译： 流体装置（1）具有构造成容纳包含微生物培养物（6）的3D培养基质（2）的培养室（10）。 通过在培养室（10）的不同端部（12,14）处提供相应的流体流并且包括不同浓度的测试物质，在3D培养基质（2）上建立测试物质的浓度梯度。 基于3D培养基质（2）中的边界区域（5）的位置确定微生物（6）对测试物质的响应。

    NEW USE OF A FLUIDIC DEVICE
    8.
    发明授权
    NEW USE OF A FLUIDIC DEVICE 有权
    流体装置的新用途

    公开(公告)号：EP3019625B1

    公开(公告)日：2018-02-21

    申请号：EP14823735.7

    申请日：2014-07-10

    申请人： Gradientech AB

    发明人： KREUGER, Johan ,  THORSLUND, Sara ,  WU, Zhigang

    IPC分类号： C12Q1/18 ,  B01L3/00 ,  C12M1/12 ,  C12M3/06

    CPC分类号： C12Q1/18 ,  B01L3/5027 ,  C12M23/16 ,  C12M25/14

    摘要： A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).