公开(公告)号：EP2391451B1

公开(公告)日：2018-09-12

申请号：EP10704614.6

申请日：2010-02-02

Applicant: Opko Diagnostics, LLC

Inventor： STEINMILLER, David ,  LINDER, Vincent

IPC: B01L3/00 ,  G01N21/03 ,  G01N21/05 ,  G01N21/59 ,  G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/574

CPC classification number: B01L3/502707 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/04 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/12 ,  C12Y304/21077 ,  G01N21/0303 ,  G01N21/59 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/545 ,  G01N33/57488 ,  G01N2333/96455 ,  Y10T436/11

Abstract: The present relation relates to a multiplex assay system comprising an article supporting solid-phase assays, said article comprising a rigid planar substrate and comprising two or more different liquid containment regions, each liquid containment region comprising at least one analysis region that can be interrogated optically, each analysis region having one or more binding partners associated with a surface of the substrate, wherein said binding partners bind one or more analytes present in a sample in the liquid containment region.

公开(公告)号：EP2069749B1

公开(公告)日：2018-06-13

申请号：EP07803554.0

申请日：2007-09-18

Applicant: Leica Microsystems CMS GmbH

Inventor： FASULKA, Robert

IPC: G01N1/28 ,  B01L3/00 ,  G02B21/34

CPC classification number: G01N1/2813 ,  B01L3/5025 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/18 ,  B01L2400/0457 ,  G01N2001/2886 ,  G02B21/34

Abstract: An apparatus for receiving biological specimens, the apparatus being introducible into a laser microdissection device for laser microdissection of a biological specimen, includes a first element having a first opening extending from a first side to a second side of the first element. A second element is provided having a second opening extending from a third side to a fourth side of the second element. The second opening is closed at the third side. The second element is disposed relative to the first element so that the first opening is aligned with the second opening. A layer is disposed between the first and second elements, the layer being designed to receive the biological specimen thereon and being capable of being cut through by laser light in a laser microdissection operation so that a portion of the biological specimen is received in the second opening so as to remain inside the apparatus.

公开(公告)号：EP3130905A4

公开(公告)日：2017-12-27

申请号：EP15776138

申请日：2015-04-09

Applicant: NATIONAL UNIV CORPORATION NAGOYA UNIV

Inventor： ARAI FUMIHITO ,  MASUDA TAISUKE ,  SONG WONEUI

IPC: G01N1/10 ,  B01L3/00 ,  C12M1/26 ,  G01N33/48 ,  G01N33/543 ,  G01N33/574 ,  G01N37/00

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/04 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/574

Abstract: Provided is a microparticle separation chip capable of continuously separating microparticles from a solution in a short period of time in which microparticles having different particle diameters are mixed, without the need to use antibodies or the like. Also provided are a microparticle separation system and method for microparticle separation using the chip. The microparticle separation chip comprises a substrate and at least three or more pillars, a single capture site for capturing to-be-captured microparticles being formed using the at least three or more pillars having one end provided on the substrate and the other end open above, the spacing Z between any mutually adjacent pillars that form the single capture site being Y

公开(公告)号：EP2793687B1

公开(公告)日：2017-05-10

申请号：EP12859868.7

申请日：2012-12-18

Applicant: Ascensia Diabetes Care Holdings AG

Inventor： BROWN, Daniel ,  MATHELIER, Martin, Antoine ,  JUNG, Sung-kwon

IPC: A61B5/00

CPC classification number: G01N33/48778 ,  A61B5/14532 ,  B01L9/00 ,  B01L2200/04 ,  B01L2300/04 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/123 ,  G01N33/48757

公开(公告)号：EP2864754A4

公开(公告)日：2016-03-23

申请号：EP13806432

申请日：2013-06-24

Applicant: LEICA BIOSYSTEMS NUSSLOCH GMBH

Inventor： FLEMING JO ,  CLEMENS CHARLES E ,  BERARDELLI DAVID

IPC: G01N1/36 ,  A61B10/00

CPC classification number: B01L3/50853 ,  A61B10/0096 ,  B01L3/502715 ,  B01L3/545 ,  B01L2300/04 ,  F04C2270/041 ,  G01N1/36 ,  G01N2001/368

Abstract: A tissue sample container including a base having a plurality of sample holding sections, which are configured to receive a plurality of tissue samples in a given orientation and are demarcated by section walls; and a lid configured to sealingly engage the base. The sample holding sections are sized and shaped to correspond to a specific tissue sample size and shape such that the base in cooperation with the section walls, maintain the given orientation and identity of the tissue samples within respective sample holding sections.

公开(公告)号：EP2991765A1

公开(公告)日：2016-03-09

申请号：EP14724296.0

申请日：2014-05-02

Applicant: Motilitycount Aps

Inventor： LARSEN, Jacob Møllenbach ,  LAURSEN, Steen Broch

IPC: B01L3/00

CPC classification number: B01L3/502753 ,  B01L2300/04 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2400/0478 ,  B01L2400/0487 ,  C12M41/46 ,  G01N1/4077 ,  G01N2001/4088 ,  G01N2015/0003 ,  G01N2015/0065

Abstract: A mesoscale fluidic system comprises a substrate having a sample chamber and an analysis chamber. The sample chamber comprises a cell permeable filter defining a sample application compartment and a conditioning medium compartment. The sample chamber has a sample inlet port in the sample application compartment. The analysis chamber has an entry port and an exit port. The conditioning medium compartment is in fluid communication with the entry port of the analysis chamber via a channel. The sample application compartment is below the cell permeable filter and the conditioning medium compartment is above the cell permeable filter. The mesoscale fluidic system is suited for analysing cellular motility in a sample. Also disclosed is a method of estimating the quantity of motile cells in a sample and a method of extracting motile cells from non-motile cells.

Abstract translation: 中尺度流体系统包括具有样品室和分析室的基底。 样品室包括限定样品施加室和调节介质隔室的细胞可渗透过滤器。 样品室在样品应用室中具有样品入口。 分析室具有入口和出口。 调节介质室通过通道与分析室的入口流体连通。 样品应用室位于细胞可渗透过滤器下方，调理介质室位于细胞可渗透过滤器的上方。 中尺度流体系统适用于分析样品中的细胞运动性。 还公开了一种估计样品中运动细胞数量的方法和从非运动细胞提取运动细胞的方法。

公开(公告)号：EP2793687A4

公开(公告)日：2015-12-23

申请号：EP12859868

申请日：2012-12-18

Applicant: BAYER HEALTHCARE LLC

Inventor： BROWN DANIEL ,  MATHELIER MARTIN ANTOINE ,  JUNG SUNG-KWON

IPC: A61B5/00

CPC classification number: G01N33/48778 ,  A61B5/14532 ,  B01L9/00 ,  B01L2200/04 ,  B01L2300/04 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/123 ,  G01N33/48757

公开(公告)号：EP2941480A1

公开(公告)日：2015-11-11

申请号：EP13810891.5

申请日：2013-12-11

Applicant: Inheco Industrial Heating and Cooling GmbH

Inventor： MOMBOISSE, Michael ,  GEORGE, Christian ,  LOB, Volker

IPC: C12M1/00 ,  C12M3/00

CPC classification number: B01L7/00 ,  B01L9/00 ,  B01L2300/04 ,  B01L2300/0609 ,  B01L2300/0848 ,  B01L2300/18 ,  C12M23/04 ,  C12M23/48 ,  C12M23/50 ,  C12M41/14

Abstract: The invention relates to an incubator (1) for exposing samples accommodated in sample containers (2) to a specifically specifiable temperature, comprising a sample chamber (3), the temperature of which can be controlled and which has at least one closable access opening (4), and at least one insertion and removal mechanism (7), which bears a sample container carrier (8) and by means of which the sample container carrier (8), which in turn bears a sample container (2), can be moved into the sample chamber (3) and out of the sample chamber through an access opening (4) of the incubator (1). The incubator (1) according to the invention is furthermore characterized in that the at least one insertion and removal mechanism (7) is installed completely outside of the sample chamber (3) and bears the sample container carrier (8) inserted into the sample chamber (3) even while the access opening (4) is closed.

公开(公告)号：EP2896685A1

公开(公告)日：2015-07-22

申请号：EP12884600.3

申请日：2012-09-11

Applicant: Hitachi, Ltd.

Inventor： NOZAKI, Takayuki ,  KIYAMA, Masaharu ,  ZHOU, Guangbin ,  MATSUOKA, Shizu ,  NAKAJIMA, Ryota ,  SENDA, Naoko

IPC: C12M3/00 ,  B65D77/00

CPC classification number: B01L3/508 ,  A01N1/0242 ,  B01L2200/18 ,  B01L2300/04 ,  B65B3/04 ,  C12M45/22

Abstract: The present invention provides a biological sample packaging container including: a sample storage container having a recessed part; a lid member that seals the upper surface of the sample storage container; and at least one gasket that is provided on the rear surface of the lid member or on the upper surface of the sample storage container, wherein: the sample storage container has a function of holding a biological sample therein; the lid member includes a first lid member provided with flow channel tubes that allow liquid and gas to be moved between the sample storage container and the outside, and a second lid member having no flow channel tubes; and the sample storage container is configured in such a manner that the first lid member and the second lid member can be replaced by each other.

Abstract translation: 本发明提供一种生物样品包装容器，其包括：具有凹部的样品储存容器; 用于密封样品储存容器的上表面的盖构件; 以及至少一个垫圈，其设置在所述盖部件的后表面上或所述样本收容容器的上表面上，其中：所述样本收纳容器具有将生物样品保持在其中的功能; 盖构件包括：第一盖构件，其设置有允许液体和气体在样品存储容器和外部之间移动的流路管;以及没有流路管的第二盖构件; 并且样品收容容器以这样的方式配置，使得第一盖构件和第二盖构件可以彼此替换。

公开(公告)号：EP2633909A3

公开(公告)日：2014-01-22

申请号：EP12175835.3

申请日：2012-07-11

Applicant: K-Mac

Inventor： Seo, Sung-Min ,  Park, Jae-Hyung ,  Oleksandrov, Sergiy ,  Lee, Joong Hwan ,  Paek, Mun-Cheol ,  Ku, Su-Jin

IPC: B01L3/00 ,  B01L7/00

CPC classification number: B01L3/50851 ,  B01L7/52 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/16

Abstract: Provided is a bio-reaction device chip for confirming or detecting a biomaterial reaction, and more particularly, is a bio-reaction device chip, where a plurality of wells are formed in the plate to contain biomaterials to be tested, thereby simultaneously analyzing various targets, and the well is formed to have a structure of two or more steps such that the sample to be tested is contained in the lower well and a protective layer for protecting the sample, such as oil, is contained in the upper well, thereby preventing evaporation of the sample due to heating at the time of the biomaterial reaction, and thus, improving reliability in analysis.