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    ASENAPINE-CONTAINING ADHESIVE PATCH
    2.
    发明公开
    ASENAPINE-CONTAINING ADHESIVE PATCH 审中-公开

    公开(公告)号：EP3861999A1

    公开(公告)日：2021-08-11

    申请号：EP19869454.9

    申请日：2019-09-25

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： YUKUHIRO, Masaki ,  TAKAGI, Yuka ,  AMANO, Satoshi

    IPC分类号： A61K31/407 ,  A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/34 ,  A61P25/18

    摘要： An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

    PATCH
    3.
    发明公开
    PATCH 审中-公开

    公开(公告)号：EP3744322A1

    公开(公告)日：2020-12-02

    申请号：EP19743954.0

    申请日：2019-01-23

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： TANAKA, Yusuke ,  SATO, Masahiro ,  YOSHINAGA, Takaaki

    IPC分类号： A61K31/165 ,  A61K9/70 ,  A61K31/045 ,  A61K31/05 ,  A61K31/125 ,  A61K31/618 ,  A61K36/534 ,  A61K47/02 ,  A61K47/32 ,  A61P17/00 ,  A61P17/04 ,  A61P29/00

    摘要： The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein
    the adhesive agent layer is non-aqueous,
    the adhesive agent layer contains nonylic acid vanillylamide and aluminum hydroxide,
    a content of nonylic acid vanillylamide in the adhesive agent layer is 0.01 to 0.025% by mass based on a total mass of the adhesive agent layer,
    a content of aluminum hydroxide in the adhesive agent layer is 0.55 to 1.5% by mass based on the total mass of the adhesive agent layer, and
    a mass ratio of the content of nonylic acid vanillylamide to the content of aluminum hydroxide ((content of nonylic acid vanillylamide) : (content of aluminum hydroxide)) in the adhesive agent layer is 1:27 to 1:150.

    METHOD FOR PRODUCING MICRONEEDLE DEVICE
    6.
    发明公开
    METHOD FOR PRODUCING MICRONEEDLE DEVICE 审中-公开

    公开(公告)号：EP3586905A1

    公开(公告)日：2020-01-01

    申请号：EP18756585.8

    申请日：2018-02-20

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： KOBAYASHI Toru ,  MATSUDO Toshiyuki ,  NISHIMURA Shinpei ,  TOKUMOTO Seiji ,  KUWAHARA Tetsuji

    IPC分类号： A61M37/00

    摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.